Role of molecular strain in crystallization―Organic crystal structures, which have long been utilized in industrial-scale crystallization, can sometimes undergo sudden and unexpected transitions to alternative, more thermodynamically stable arrangements, resulting in markedly different physical properties. In their article in @J_A_C_S, van de Streek, Neumann et al. present a method for calculating “molecular strain energy” to predict the likelihood that a molecule will adopt its most thermodynamically stable crystal packing arrangement. This study not only elucidates the unexpected crystallization of more stable, novel solid forms but also provides the pharmaceutical industry with a valuable tool for directing resources more effectively. Full article: pubs.acs.org/doi/10.1021/jac…