Zac Germon retweeted
proteomic landscape of diffuse midline glioma highlights the therapeutic potential of non-histone protein methyltransferases academic.oup.com/neuro-oncol…
Had a great day at @TheASMR1 Hunter meeting. Grateful to have been awarded Best ECR/MCR talk on the day!
Thanks Heather, looking forward to it!
On July 18, I'll be hosting @XuDongZhang15 and @ZacGermon at an online seminar for @AEpiA. I'm looking forward to showcasing the work of two great colleagues from @UON_research and @HMRIAustralia . Tune in for some fabulous science and discussion!
6
230
Thanks @CancerAustralia & @KidsCancerProj! Excited to be given the opportunity to continue this project investigating much needed novel treatment strategies for Paediatric cancers #AML #DMG #DIPG
Delighted #DunLab 's childhood cancer project was funded by @CancerAustralia & @KidsCancerProj
Free-radicals (#ROS) promote cancer signaling in RTK mutant- #AML & #DMG #DIPG
Here we will develop new targeted treatments
Congrats @ZacGermon @duchatel_ryan @Jonatha16752881 DE & ID
Zac Germon retweeted
Wonderful to see the glossy version & cover of #DunLab’s latest paper discovering the genetic dependency & targeting of PI3K in #DIPG #DMG
Huge thanks to the funders & parents who donated their child’s tissues to help us in this & all our important studies doi.org/10.1172/JCI170329
#Cover: Targeting PI3K/mTOR in diffuse intrinsic pontine glioma: buff.ly/3TAz4Jd
#Image presents a model whereby the connectivity of these cancers can be harnessed using integrated technologies to identify potential therapeutic strategies.
#Oncology #Therapeutics
Congratulations @MattDun17! So well deserved. Your dedication and determination inspire us each day in the fight against kids cancer!
So thankful to receive this prestigious award on behalf of our incredible #DunLab team
May I thank all our #CSRG team & recognise the inspirational scientists that did all the work particularly @evierjackson @duchatel_ryan @AliciaD0uglas @DilanaStaudt @ZacGermon #DIPG 💪 @RUNDIPG
7
293
Congrats, Sam and team! A super interesting review. Thank you for the opportunity to contribute.
Our new review on #hypoxia and #DNAmethylation in #AML is online today. We explored complex and bi-directional interactions between hypoxia signalling and regulation of DNA methylation as well as implications for AML therapy.
clinicalepigeneticsjournal.b…
5
208
Congrats Evie and team! Great summary of this paper below.
Incredibly proud to share the latest work from #DunLab, published in #CancerResearch! We highlight the combination of ONC201 and paxalisib for the treatment of DMG, the preclinical data informing PNOC022. Follow this tweetorial for a summary: (1/10)
aacrjournals.org/cancerres/a…
6
433
Zac Germon retweeted
A new study shows that inhibiting the oxidase NOX2 suppresses a common subtype of #AcuteMyeloidLeukemia (AML) in mice by blocking ROS in cancer cells—hinting that targeting NOX2 may potentiate precision therapies for AML. @ZacGermon @MattDun17 scim.ag/26a
Zac Germon retweeted
Probably my favourite part of adding to the literature, students/stuff pinning their first author papers to our walls of honour!
#DunLab #CSRG
#DunLab paper alert:
Patients diagnosed with the most common driver mutation in acute myeloid leukemia (AML) – FLT3, are associated with poor-outcomes.
FLT3+ AML sees the overproduction of reactive oxygen species (ROS), a second messenger signaling (T1)
doi.org/10.1126/scisignal.ab…
Excited to see this paper published today in @scisignal. This work formed a large part of my PhD and is summarised below:
#DunLab paper alert:
Patients diagnosed with the most common driver mutation in acute myeloid leukemia (AML) – FLT3, are associated with poor-outcomes.
FLT3+ AML sees the overproduction of reactive oxygen species (ROS), a second messenger signaling (T1)
doi.org/10.1126/scisignal.ab…
Zac Germon retweeted
Access to new drugs in paediatric oncology: can we learn from the ongoing ONC201 saga? @TheLancetOncol #DunLab, #CSRG @UON_research @HMRIAustralia @RUNDIPG thelancet.com/journals/lanon…
A wonderful Ashley Dunn oration from Prof. Karen Vousden @LorneCancer @LabVousden. Exciting and motivating to hear her elegantly discuss (my fave molecules!) ROS and their importance in tumour development and progression.
3
149
Thanks for the support @PrecisionMedUON. Glad to be part of the team!
#MeetTheTeam: Introducing Dr Zac Germon who is a Postdoctoral Fellow in the Cancer Research Signalling Group focused on proteomic, genetic & epigenetic approaches to understand the surrounding microenvironment of #Leukaemia & #DIPG to develop novel treatment strategies @ZacGermon
10
459
Zac Germon retweeted
Gr8 recent achievements to celebrate @ #DunLab
@TabMclachlan targeting BCL6 in pediatric cancers - bit.ly/3V5xrka
@DilanaStaudt #pHASED real-time phosphoproteomics data to aid in cancer drug selection rdcu.be/c3Jc8
Mika Persson cover of @NeuroOnc
Congrats Team!
Zac Germon retweeted
Excited to see the latest #DunLab pub out 2day led by @DilanaStaudt Here we have optimized a new protocol, phospho-heavy-labeled-spiketide FAIMS stepped-CV DDA #pHASED to identify oncogenic cascades to aid in drug selection for cancer patients in real-time
rdcu.be/c1Veg
Happy to have my PhD awarded to round out a great day at the @PrecisionMedUON symposium. Go team! A sincere thankyou to my mentors and supervisors @MattDun17 @DeVerrills @Dr_Heather_Lee @geoffdeiuliis and everyone along the way who made it possible.
This quoted post is unavailable.
Such a great few days @NDLR_conference, so grateful to have been given the opportunity to present my work and to hear about some of the amazing work going on in the field. Exciting times!
My newest fave #DunLab / #CSRG tradition is congratulating my just submitted PhD student @ZacGermon on winning the @NDLR_conference New Investigator award for his pioneering work showing oxidative stress promotes altered epigenetic profiles in #AML
Super proud Z, congratulations!
1
17