enzymologist | physical biochemist | director, BSOM's MS Core Facilities | studies IDPs, allostery, and redox in neurodegenerative diseases | opinions my own.
Greenville, NC
Joined May 2018
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Working on some manuscripts and grants right now. Needed to see this.
Tonya Zeczycki retweeted
Abbvie @abbvie announces that their once-daily drug, tavapadon, improves #Parkinsons patient mobility in late-stage study
reuters.com/business/healthc…
Tonya Zeczycki retweeted
Check out the 2024 Emerging Investigators Issue for @J_ASMS. The future of mass spectrometry is definitely in good hands!!
pubs.acs.org/toc/jamsef/35/1…
Tonya Zeczycki retweeted
Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out @NatureBiotech !
Read here👉: doi.org/10.1038/s41587-024-0…
🔬 Highlights:
- Uses an experimental library of peptide markers integrated with a structural proteomics workflow.
- Probes the assembly state of hundreds of protein complexes simultaneously across conditions directly from whole cell extracts, informing on binding interface occupancy.
- Supports the structural modelling of protein complexes and the design of compounds targeting them
Congratulations to shared first authors @CathyMarulli and Christian Dörig and thanks to our collaborators @LabBarral and @TorstenSchwede lab
@ETH_en #Proteomics #PPIs #SystemsBiology #LiPMS #teammspec #DrugDiscovery
Tonya Zeczycki retweeted
Rethink the analysis of DDA data! Blurring the boundary between DDA, WWA, and DIA, #MSFragger-DDA+ Enhances Peptide Identification Sensitivity with Full Isolation Window Search. Fully integrated in #FragPipe, simply annotate your DDA files as DDA+ and RUN. biorxiv.org/content/10.1101/…
Tonya Zeczycki retweeted
The synuclein seeding assays are not enough to diagnose Parkinson and to differentiate it from PSP and MSA. Dr Edwin Jabbari @ucl makes a convincing argument that kinetics matter and combination assays will be the path forward. A combo assay that includes a 4R Tau assay has great potential. 1/3 of LRRK2 negative cases w/ current synuclein assay and also over 7% completely negative. Congrats on junior MDS award. #mdscongress #parkinsom
Working with my lab peeps and collaborator this week has, once again, reminded me why I love what I do and that I truly have the best "job" in the world.
Tonya Zeczycki retweeted
I try not to brag about our papers when they come out, but for this one I make an exception. It is a clinical trial showing that our new drug combination is effective in pain patients. It will be published in Frontiers in Pain Research.
@ECUBrodySOM @ECUResearch @RLSFoundation
Tonya Zeczycki retweeted
We are thrilled to share our latest preprint on the Anti-Müllerian Hormone and its unique signaling pathway. Our first ever cryo-EM structure represents a breakthrough over 40 years in the making. 🧬🔍
(@drewhow66)
Check out our findings here:
biorxiv.org/content/10.1101/…
1/10
Tonya Zeczycki retweeted
👋A.M.A.Z.I.N.G. 👋 Refresher paper on
Understanding isotopes, isomers, and isobars in mass spectrometry: sciencedirect.com/science/ar… Checkout!
#isotope #isobar #isomer #massspec #metabolomics #multiomics #proteomics
Tonya Zeczycki retweeted
Very excited to see work from Hanna Budayeva included in this special issue of @JProteomeRes. Hanna has done a fantastic job leading our chemoproteomics efforts over the last few years - this story is just one of the exciting things her group is working on! Check out this issue!
The latest issue of Journal of Proteome Research is live! On the cover: "Celebrating Women in Proteomics and Metabolomics"
Read it here: pubs.acs.org/doi/full/10.102…
Tonya Zeczycki retweeted
Important to de-stigmatize mental health efforts for Graduate Students.
How PhD students and other academics are fighting the mental-health crisis in science nature.com/articles/d41586-0…
Tonya Zeczycki retweeted
"I am a huge proponent of do-it-together biology, not do-it-yourself."
Photos and interview with @ATinyGreenCell in @AsimovPress.
Worth updating your mental model on amateur biology. There's an important future being crafted in this spare bedroom lab.
Tonya Zeczycki retweeted
Humbled and honored to have been awarded this: rlsfoundation.blogspot.com/2…
I hope I can continue meeting the expectations!
@ECUBrodySOM
@ECUResearch
@ECU_Neuro
@EastCarolina
@RLSFoundation
Tonya Zeczycki retweeted
Please RT: We have Senior Scientist, Postdoctoral Researcher and PhD student positions available in our lab focusing on the role of Hsp70 PTMs in a variety of processes including cancer, aging and host-pathogen interactions. Please see: trumanlab.org/contact #hsp70 #chaperones
Wiggles, jiggles, and dangly bits? What more can you ask for?
Awesome paper from @idpemery with the @alexholehouse lab....
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Tonya Zeczycki retweeted
The potential adverse interactions of #SARSCoV2 and Parkinson's disease, as assessed in human embryonic stem cells and the mouse model
cell.com/cell-reports-medici…
@CellRepMed
Tonya Zeczycki retweeted
"this duality of Parkinson’s: It is both unfathomably complicated, complex, and difficult, and at the same time one of the clearest and most persistent invitations imaginable to grow, persevere, and be great." - Christopher Krueger @DavisPhinneyFND
bit.ly/3PXws61
Tonya Zeczycki retweeted
It's not just fold switchers. AF2 struggles to predict alternative conformations of other proteins as well. Nice work on AF2-RAVE, @tiwarylab
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