
Marie Skłodowska-Curie Postdoctoral Fellow at CRCA-CBI #Microglia #Exercise #microbiota #GutBrainAxis #Alzheimer
Toulouse, France
Joined September 2017
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🎉 New paper out in @BrainBehavImm We asked a simple question: does exercise still benefit the brain when it’s inflamed? Short answer: not really.
@yvonnemnolan @oliviafoleary @UCC @AnatNeuroUCC @Pharmabiotic
Here’s what we found ⬇️
Sarah Nicolas retweeted
Intestinal infections establish antigen-specific, long-lived memory CD4+ T cells in the brain and meninges
nature.com/articles/s41593-0… @NatureNeuro
Sarah Nicolas retweeted
For anyone interested, here are links to publications arising from this work:
- lnkd.in/eNCeTh3w
- lnkd.in/eVQYem2C
- lnkd.in/ec2DUFUB
Sarah Nicolas retweeted
I’m delighted to share that this summer I officially graduated with my PhD in Neuroscience, under the supervision of Prof. @yvonnemnolan , Prof. @oliviafoleary and Dr. @_Sarah_Nicolas.
Sarah Nicolas retweeted
Exercise-driven microbiome changes regulate host immunity
cell.com/trends/immunology/a…
Sarah Nicolas retweeted
My research on mice is causing me stress. How can I become more resilient?
nature.com/articles/d41586-0…
At #FENS2026? Come check out poster 291! @zapwilliams is presenting her phd work on sex-specific effects of exercise on behaviour, neurogenesis & the gut microbiome in an AD mouse model. Want to learn more about the gut-brain axis in Alzheimer’s? Stop by poster 291! @FENSorg
Finally, IL-1β increased CD8⁺ T cell infiltration into the dorsal hippocampus, independently of exercise. These cytotoxic T cells negatively correlated with neurogenesis, suggesting they may directly suppress new neuron survival.
Take-home message: inflammatory status alters how the brain responds to exercise. This may have relevance for conditions like long COVID, chronic fatigue, and ageing, where exercise tolerance and brain plasticity are both compromised.
Link to article👉 doi.org/10.1016/j.bbi.2026.1…
Acute stress makes it difficult to link memories of past events with fresh information, a study1 suggests. The results help to explain why people struggle to show insight under pressure.
go.nature.com/4umkMMc
Sarah Nicolas retweeted
It’s not review unless it comes from the Review region of France, otherwise it’s just sparkling criticism
Sarah Nicolas retweeted
Academia feels increasingly like playing Monkey Island, if you miss something as absurd as picking up a rubber chicken with a pulley in the first scene, you only realize much later that you’re stuck and can’t pass to the next stage.
I was interviewed today by @ScienceMagazine about the funding crisis following the ERC announcement. I argued that when a grant rejection can hinge on something small, and you then have to wait years to resubmit, the cost becomes so high that instead of suggesting “high-risk high-gain” plans scientists will prepare more cautious, less ambitious proposals. It turns into a perverse game of simplifying your ideas and trying (unsuccessfully) to predict what an overstretched reviewer pool will find easiest to digest.
"Abrupt change to European funder’s rules leaves researchers shut out | Science | AAAS" science.org/content/article/…
Sarah Nicolas retweeted
How every layer of science's "self-correcting machinery" failed when Iva Veseli and I simply wanted to reproduce the findings of a high-profile study on gut microbiome and autism:
merenlab.org/2026/04/15/unfa…











