Proud present our latest work led by @_blessypaul, now in Developmental Cell @Dev_Cell. Here, we characterize an ER-localized antioxidant enzyme in humans and Drosophila that acts as a lipid quality control factor to suppress ER lipid oxidation. cell.com/developmental-cell/…

Please re-tweet! We're searching for a Drosophila lab technician! Interested in Drosophila as a model to study metabolism & lipid biology? Please DM for details. Ideal position for recently graduated undergraduates interested in research experience prior to grad school.

Excited about our preprint led by the amazing @_blessypaul w/ collabs from Jeff McDonald (UTSW) and Steve Farber (Johns Hopkins)! Here we characterize the paraoxonase-like enzyme APMAP, showing it helps maintain lipid & lipoprotein homeostasis @ the ER. biorxiv.org/content/10.1101/…

Happy holidays from the @HenneLab, having painting fun at our end-of-year day out.

Lipid droplets exhibit many functions including energy storage organelles & metabolic buffers. Did you know they also likely serve as optical light filters in chicken cone cells? Learn about this & more in this interesting paper now out in @Dev_Cell. cell.com/developmental-cell/…

Extremely proud of grad student @naaatalieortiz! See her paper, now out in @JCellBiol, where she characterizes a regulator of lipolysis that decorates TG-rich LDs. rupress.org/jcb/article/223/…

Did you know you can monitor the biophysical phases of #lipid_droplets (LDs) using polarized light microscopy? Learn about this and other interesting aspects of LD biology in our recent mini-review/perspective in Current Opinion in Cell Biology, here: doi.org/10.1016/j.ceb.2023.1…

Meme your science: Triglyceride (TAG) rich lipid droplets are substrates for hungry TAG lipases. Are there ways cells protect some LDs from lipolysis? See our preprint to learn about Bsc2, which decorates a subset of TAG-rich LDs and inhibits breakdown. biorxiv.org/content/10.1101/…

New preprint! Led by @naaatalieortiz, here we characterize yeast protein Bsc2, showing it localizes to a sub-population of lipid droplets (LDs). Our data support a model where Bsc2 acts as a 'triglyceride sensor' on a LD subset to regulate lipolysis. biorxiv.org/content/10.1101/…

At ASCB #cellbio2022 & interested in lipid droplets? Check out some LD talks! ASCB is a great venue for trainees to speak! see @naaatalieortiz's talk on LD functional diversity see @RupaliUgrankar's talk on LD-cytoskeletal crosstalk see Mike's talk on liquid-crystalline LDs

Many thanks to Deborah Wormser and the @UTSWNews Newsroom for highlighting our collaborative study on the phase transition properties of cholesterol. utsouthwestern.edu/ctplus/st…

Super proud of grad student Natalie Speer @naaatalieortiz who will give a talk at @ASCBiology Symposium "Metabolism from Cells to Organisms" this Dec! #ProudPI Interested in how proteins 'label' specific lipid droplets & dedicate them to specific functions? See Natalie's work!

Attending ASBMB and interested in interorganelle crosstalk? Attend the organelle signaling session Sunday Apr 3 9:30-11:30 Rm126A. Hear about work from @_blessypaul, @brettcollins100, @HenneLab and others about the SNX-RGS proteins and their roles in interorganelle crosstalk

Congrats to @brettcollins100 & @_blessypaul! Paper suggests novel lipid binding module in SNX-RGS proteins via PXA-PXC domain interactions at interorganelle contacts. Great example of Alphafold solving riddles we've struggled to experimentally resolve. doi.org/10.3389/fcell.2022.8…

Stay thirsty for discovery, cell bio folks

A highlight from @_blessypaul in @NatMetabolism on work from the Wolfrum lab. Interesting study that dissects PEX2 as a sensor of cellular ROS to fine-tune ATG-mediated lipolysis. nature.com/articles/s42255-0… You can read the original Ding et al study here: doi.org/10.1038/s42255-021-0…

Neat preprint from @brettcollins100, @_blessypaul, @hanahariri & others using crystallography & Alphafold to dissect architecture of SNX-RGS proteins. Surprisingly, two domains appear to fold together forming a new lipid binding/transfer module. biorxiv.org/content/10.1101/…