AboutNAD

NAD+ doesn’t work alone. It belongs to a network of coenzymes, precursors, enzymes, and breakdown products known as the NAD metabolome. Learn how the body makes, uses, and recycles NAD+ and why the bigger picture matters. bit.ly/4iLNphb

Frailty is a broad loss of the body's reserves and resilience, increasing vulnerability to illness and disability. A new GeroScience study of 529 older adults examined whether whole-blood NAD+ is associated with frailty. Learn what it found. agehealthy.me/4BqYoW5

Most research on nicotinamide riboside (NR) has centered on oral supplementation—until now. A new two-part pilot study goes further, examining the effects of injectable NR on fatigue, sleep, oxidative stress, and skin health. Read the findings: bit.ly/4igTa6B

Most NAD+ and skin-related research has relied on cells and ex vivo tissue. Now, the field is moving into human research, with the first controlled studies of standalone topical NR providing early evidence on tolerability and skin outcomes. Learn more: bit.ly/4eC6UaH

Could raising NAD+ influence mitochondrial disease? A new human study of nicotinamide riboside (NR) found changes in NAD+-related and mitochondrial pathways, with the clearest muscle-level signals in participants with large-scale mtDNA deletions. bit.ly/4y5slIo

What's driving NAD+ decline in aging reproductive tissue? A new study points to CD38, an enzyme that consumes NAD+ to carry out its functions. Here's what the researchers found: bit.ly/4cMzXYv

NR is often treated as a single ingredient, but nicotinamide riboside exists in several distinct salt forms—including NR chloride & NR hydrogen malate, among others—each with its own structure, research depth, & regulatory status. Here's a closer look: bit.ly/4xqqcGG

Oxidative stress and aging share a bidirectional relationship: age-related changes increase oxidative stress, and accumulated oxidative damage, in turn, accelerates aging. This blog unpacks that relationship—and where NAD+ research currently stands. bit.ly/4i95kji

Metabolic health isn't just about weight—it reflects how efficiently your body manages blood glucose, insulin sensitivity, & cellular energy. GLP-1 drugs & NAD+ each play a role, but at very different levels of that system. Here's how they compare: bit.ly/3SHn8I6 #GLP1

Autoimmune diseases occur when the immune system attacks the body's own tissues. Researchers are now exploring how cellular metabolism—specifically NAD+—may influence this process across seven conditions. Here's what the emerging science shows. bit.ly/4wEGNqT

Inflammation is one of the body's most essential defenses—but when it becomes chronic & low-grade, it can quietly undermine health over time. This shift is at the core of inflammaging, & emerging clinical research suggests NAD+ may play a role. Learn more. bit.ly/3R2OQOM

Werner syndrome and ataxia telangiectasia are rare diseases linked by genomic instability and features of accelerated aging. Early human studies suggest NAD+ precursors may improve clinical markers across these and other rare conditions. Learn more. agehealthy.me/4vqasmk

Every muscle contraction, recovery window, and repair cycle depends on NAD+. It sits at the center of how muscles produce energy, making it essential to nearly every aspect of muscle function. Its levels, however, decline with age and inactivity. Read more:bit.ly/49KUpHD

New research is challenging the idea that NAD+ universally declines with age—but the study measured blood NAD+, not tissue levels. Findings from direct human tissue studies in the brain, muscle, skin, and liver suggest a more nuanced picture. agehealthy.me/4wSWR93

The brain is one of the most energy-demanding organs in your body—and it depends heavily on NAD+. As NAD+ declines with age, so may neuronal resilience. But what does that mean for brain health? agehealthy.me/4fIuUdI

In March, the world's leading NAD+ researchers gathered at the NAD for Health 2026 conference for a conversation the field has long needed. Early clinical signals, the synergy between exercise & supplementation, & an honest look at where the science stands.agehealthy.me/3R5JVvX