@IMI_JU Project identifying new medicines to treat #Alzheimers Disease through greater understanding of the APOE gene.
Joined July 2018
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ADAPTED retweeted
Read this new paper from @FundacioACE in tight colaboration with @SantPauMemory #BarcelonaAlzheimersResearchHUB members investigating #apoe alleles supposed to be protective. @ApoEdscvr @adapted_project
Thanks @jordiclarimon for pushing this research! onlinelibrary.wiley.com/doi/…
ADAPTED retweeted
Our @IMI2_NEURONET annual campaign showcasing #neurodegeneration projects and the people behind them concludes today. Check out the graphics and links to interesting content via the hashtag #WeAreNeuronet.
@IMI_JU @EFPIA @EU_H2020
.@IMI2_NEURONET is launching a social media campaign to highlight the value of public-private collaboration and celebrate @IMI_JU's partnerships in #neurodegeneration #research.
Keep your eyes peeled!
#HealthierFuture #WeAreNeuronet #WorldAlzMonth
bit.ly/2DOyCmy
ADAPTED retweeted
Santos Mañes from @CNB_CSIC collaborates with the @adapted_project.
Read about his work here: bit.ly/ADAPTED_Manes
#HealthierFuture #WeAreNeuronet #WorldAlzMonth
@IMI_JU @EFPIA @EU_H2020
ADAPTED retweeted
What value do you see in public-private collaboration? We spoke to Bridget Glaysher from @ModusRI.
bit.ly/ADAPTED_website
@IMI_JU @EFPIA @EU_H2020 #HealthierFuture #WeAreNeuronet
ADAPTED retweeted
@adapted_project Interesting function of intracelular lipid droplets. @ApoEdscvr #APOE in microglia and astrocytes might be involved in these general process.
A study published in the journal Science and coordinated by researchers of IDIBAPS and the UB describes a new immune defence mechanism unknown until now 👉 bit.ly/3j6wjtv
ADAPTED retweeted
@ApoEdscvr @alpimen72 @adapted_project #APOE and #TREM2 interaction motifs. We predicted the same functional path for them using coreg networks. Plcg2 and complement system could part of the same history. link.springer.com/article/10…
Pleased to share our latest article mapping a new fxnal surface on TREM2 for ApoE and a new sTREM2 fxn! @dlkober @HBDeanMSTP @RobersonLabUAB
Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1‐42 alz-journals.onlinelibrary.w…
ADAPTED retweeted
@ApoEdscvr @alpimen72 @adapted_project Another independent evidence of #trem2 and #apoe "risk loci operating together in the mci context
Happy to share our new paper out in @MolNeuro: We show that higher #sTREM2 is associated with attenuated effects of #APOE4 on cognitive decline and neurodegeneration.
Many thanks to @M_SuarezCalvet @timothyjhohman
@MichaelEwers12
and many others! #endalz
rdcu.be/b8gmE
ADAPTED retweeted
Read this new paper from @FundacioACE in the context of @adapted_project @ApoEdscvr Exploring the metabolomic impact of APOE genotypes in CSF lysophosphatidic acids. Thanks to #Hankemeier lab at @UniLeiden , Cornelia van Duijn and @alpimen72
alzres.biomedcentral.com/art…
ADAPTED retweeted
The @adapted_project, which ended last month, has published several papers. Have a look on them here:
bit.ly/ADAPTED_publications
@UniofOxford @IMI_JU @EFPIA @EU_H2020
#HealthierFuture #WeAreNeuronet
ADAPTED retweeted
The fifth issue of the @IMI2_NEURONET #newsletter is out now!
This issue introduces you to fantastic early-career researchers & provides you with updates on progress and achievements from the @IMI_JU #neurodegeneration #research projects. Don’t miss it↩️
bit.ly/342NEhG
ADAPTED retweeted
Our July newsletter is out! We've got news on our first #COVID19 project, plus successes from our projects on #Ebola, #tuberculosis, #blockchain, #COVID19...
Read it at bit.ly/3hUOjqz
#IMICarryTheTorch #EUHealthResearch #H2020
ADAPTED retweeted
@alpimen72 @adapted_project Dissecting the transcriptomics around #alzheimers plaques. Complement, myelin, oligodendrocytes and beyond
New Resource online now at Cell: Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease zpr.io/HGjbK
ADAPTED retweeted
🔴 NEW PAPER ALERT
"CDH6 and HAGH protein levels in plasma associate with #Alzheimers disease in APOE ε4 carriers" @ciberned @adapted_project @ErasmusMC @ApoEdscvr #apoe
Read it here 👉 go.nature.com/2TAJLfg
@nature
ADAPTED retweeted
@adapted_project @ApoEdscvr we can continue looking for fancy/ fashionable phenotypes in cells and tissues. But if you correct massive plasma phenotype of #apoe most probably you will be correcting a big fraction of its effects. Yes! it is a lipoprotein!
nature.com/articles/s41467-0… – at La Garriga, España
ADAPTED retweeted
@ApoEdscvr @adapted_project It makes sense that TREM2 could be involved in lipid metabolism assuming it's connection with #APOE – at La Garriga, España
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ADAPTED retweeted
MS4A loci and complement factors. A link that deserves attention for #Alzheimers @FundacioACE @adapted_project – at La Garriga, España
EXCITING first structure of an MS4A family member! CD20 (MS4A1) in complex with therapeutic Fab by cryo-EM! Great framework to begin understanding MS4A proteins linked to AD!
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab science.sciencemag.org/conte…
ADAPTED retweeted
We're excited about the 12th @FundacioACE Barcelona - Pittsburgh Conference where 4 @IMI_JU
projects will join up for a panel dedicated to #European #Alzheimer's disease research. @adapted_project @IMI_EPAD @IMI_AMYPAD @MopeadEU
fundacioace.com/bcnpit/
ADAPTED retweeted
Now microglia looks the center of everything but Remember that those signals are shared by the entire immune system and Brainstorm Consortium data on >1million people pointed to sistemic causality for #Alzheimers and other neurological conditions. @adapted_project @FundacioACE
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ADAPTED retweeted
Are you interested in European research collaboration in #Alzheimer's disease and beyond?
Have a look at the @AlzheimerEurope magazine featuring our @IMI2_NEURONET event at #29AEC.
The magazine is available for free download: bit.ly/DementiaInEuropeMagaz…
ADAPTED retweeted
How can we gain better insights into the causes of #Alzheimer’s disease?
Watch this video presentation by @mesaezgoni from the Andalusian Centre of Bioinformatics studies to learn about
the @adapted_project
youtu.be/hAoe8mIkn8g