Passionate about justice & tolerance, teaching & educating oncologists, caring for cancer patients, learning from mistakes. Opinions and statements are my own.

Tennessee, USA
Joined March 2009
I strongly believe that we should merge FOLFOXIRI and FOLFIRINOX into one regimen that we all agree on! @OncoAlert poll - what is your regimen of choice (IOF)?
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Axel Grothey retweeted
HARMONi-GI1, presidential session at #ESMO26. @UGrewalMD guessed .7 HR
I guessed .8 HR
We were equally right (.75 HR). Phase 3, 1L advanced biliary tract cancer: ivonescimab (PD-1 x VEGF) + GemCis vs durvalumab + GemCis. 682 patients, median follow-up 14.3 mo. OS 14.9 vs 12.1 mo, HR 0.75 (95% CI 0.61-0.92), p=0.0031 
PFS 8.4 vs 5.8 mo, HR 0.61 (95% CI 0.51-0.72) 
ORR 53.8% vs 32.5% This was an appropriate comparator for 2026 and compelling data (although really did need every one of those patients to power). Probable new first line once the full data comes out. The bispecifics era is in full force. @OncoAlert @TheGutOncLab @UGrewalMD @Onco_Nexus
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VIDEO: Neoadjuvant nivolumab + ipilimumab in stage II–III dMMR colon cancer? NICHE-2 (Lancet, Oct 21, 2026): 3-yr DFS 100% 🧬📊 👉 oncologytube.com/colon-cance… 🔹 Single-arm phase 2 (NCT03026140): ipilimumab 1 mg/kg day 1 + nivolumab 3 mg/kg days 1 and 15, then surgery; 111 in the efficacy population, median follow-up 60.4 mo 🔹 3-yr DFS 100%, the primary endpoint; exploratory post-hoc 5-yr OS 100% 🔹 ctDNA cleared before surgery in 80 of 97 evaluable patients (82%); all were ctDNA negative after surgery No randomized comparator, and not FDA-approved for this use. Universal MMR/MSI testing at diagnosis is what makes the neoadjuvant conversation possible. Does not extend to pMMR or rectal cancer. #crcsm #ColonCancer #dMMR #Immunotherapy #GIOnc #ColorectalCancer @MyriamChalabi @GillSharlene @DraMartinezLago @GIMedOnc @UGrewalMD @ChandrakanthMv @dr_yakupergun @CathyEngMD @GIcancerDoc @KimmieNgMD @VanMorrisMD @KristenCiombor @RonaYaeger @marklewismd @benweinbergmd @agrothey @aakonc @EileenMOReilly @FASinicropeMD @ilyassahinMD @smitha42 @skopetz @ArndtVogel @ryanhuey @OncoThor @DrRishabhOnco @YannickBuccella @KaiKeenShiu @jgong15 @drallysonocean @Erman_Akkus @DaisukeKotani @TapiaJC1 @geoffreybuckle @AndreaCercek
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Published today @TheLancet NICHE-2: 4 weeks of immunotherapy + surgery ➡️ 100% 3-year DFS and 100% 5-year OS in dMMR colon cancer. Congratulations to @MyriamChalabi et al ⭐️ Pleased to author the editorial commentary with @jonathanloree on these remarkable results and potential Implications of what comes next. doi.org/10.1016/S0140-6736(2… @BCCancer
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Axel Grothey retweeted
NICHE-2 | 5-year results Just 2 doses of neoadjuvant nivo + 1 dose of ipi, followed by surgery... Not a single recurrence after nearly 5 years of follow-up, and 5-year OS was 100%! What more could we ask for? I'm truly at a loss for words👏 thelancet.com/journals/lance…
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Factcheck of Trump’s (Putin’s???) lies about Ukraine.
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RIP @rachnatshroff May your memory be a blessing to all who knew you and loved you. As a GI oncologist, I promise to carry forward Dr. Rachna Shroff’s extraordinary legacy through our unwavering commitment to developing better therapies for our patients. Her passion, leadership, and dedication to advancing cancer care will continue to inspire us. We will honor her by pushing science forward, never losing sight of the patients and families who are counting on us. 💜 nbcnews.com/health/disease/r…
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Axel Grothey retweeted
I am a member of the Norwegian Nobel Committee. There are five of us. Five people, appointed by a parliament most of the planet could not find on a map, who decide, once a year, which human being the world has agreed to call good. I know. I know. I think about it on the tram. We meet in a building on Henrik Ibsens gate, a street named after a man who wrote almost exclusively about people discovering they are frauds, which nobody on the committee finds funny except me. There is a room with a long table and the portraits of the dead laureates looking down, Mandela, the Dalai Lama, a great many earnest men in spectacles, and one portrait we do not discuss, which is Kissinger, 1973, awarded while the bombs were still falling, after which two of our predecessors resigned and the satirist Tom Lehrer said political satire was now obsolete. We keep him on the wall. A reminder. Every family has the uncle. It is October in Oslo, which means the sun gives up around four in the afternoon like a civil servant, and it rains the particular Norwegian rain that isn’t quite falling, just hanging there, judging you. I arrive with wet shoes. I always arrive with wet shoes. There is coffee, because this is Norway and there is always coffee, we drink more of it per person than almost anyone alive, and someone’s wife has sent kanelboller, the cinnamon buns, and we sit, five Norwegians, damp, caffeinated, sugared, and we decide the moral standing of the entire species. Let me tell you how it actually works, because the world imagines a cathedral and it is, I promise you, a book club with a mandate. 287 nominations this year. 208 people, 79 organizations. Anyone can nominate, that’s the secret nobody understands: a professor, a parliamentarian, a former laureate, so the “nominee” list is meaningless, it’s a suggestion box, and every autumn some congressman nominates his own golden retriever and the press writes “SHORTLISTED.” Nobody is shortlisted. There is no short list the public ever sees. There is us, and the coffee, and the rain, and the portraits, and a Norwegian stubbornness that is older than the prize itself. We read reports. The institute’s advisers write them, thick dull documents, and we argue. Our chairman told the BBC once that in the final meeting “there is a high temperature.” High temperature, for a Norwegian, means someone slightly raised an eyebrow and then apologized for it. We don’t do high temperature. We do a long silence, and then Kristin says “well,” and everyone knows exactly what “well” meant, and it’s settled. That’s our shouting. “Well.” You’d have to be raised here to hear the violence in it. Now. This year. I will not say the name, because we never say the name, but you know the name. A certain head of state wanted this prize the way a child wants a thing in a shop window, which is to say loudly, and in public, and with the full belief that wanting it was itself the argument. He said he deserved it. He said he’d ended eight wars, a number that grew most times he said it, like a fish. He had other heads of state phone us. Israel’s prime minister posted it on the internet, “Give him the Nobel.” The leaders of Cambodia and Pakistan announced they’d nominated him, as though announcing it were part of it, as though we tally mentions. A man flew around the globe collecting endorsements for a Norwegian committee the way you’d collect signatures for a petition to the council about a noisy dog. And here, uff da, is the detail I treasure, the one that makes me smile into my coffee. The nomination deadline is the 31st of January. He took office on the 20th. So for all the phone calls, all the posts, all the gilded lobbying, the only nominations that could possibly count for this year’s prize were filed in the first eleven days of his term, before he had, by his own arithmetic, ended a single one of the eight wars. He campaigned all year for a prize whose window had shut while he was still hanging up his coat. We didn’t have to reject him. The calendar did. We just watched. Norwegians are very good at watching. We have long winters. People think we sit there weighing his deeds. We don’t. That’s the thing I can’t make the world understand. We’re not grading his homework. We don’t owe anyone the prize for a ceasefire, however real, however loud the announcement. “He made peace” is not a sentence that ends in a medal, the way he believes it does, the way he believes every good thing ends in his name on it. The will of a dead Swede says the prize goes to whoever did the most for fraternity between nations. A dead Swede, I should add, who made his entire fortune inventing dynamite and selling arms, and spent his last years horrified at his own obituary, which called him a merchant of death, and so bought his way to immortality as a man of peace. The whole prize is one guilty arms dealer’s attempt to launder his name. We are, all of us, administering a dead man’s public relations. I find this clarifying. It keeps me humble. It should keep everyone humble, and it keeps, by my count, no one humble at all. So who did we give it to? An eighty-five-year-old woman. A judge. Born in Durban, under apartheid, granddaughter of a Tamil man who came to South Africa as indentured labor, a bus driver’s daughter from the poor Indian quarter, who became the first non-white woman to run a law practice in her province, who defended Mandela’s people when defending them was dangerous, who sat on the Rwanda tribunal and the court at the Hague, and who, at eighty-five, is right now a judge weighing whether a genocide is a genocide. When we told the world, our chairman said the rule of law “underpins the system we have set up to ensure peace,” and that “peace requires justice.” She wasn’t even in Oslo. She was in Nuremberg. In courtroom 600. The actual room where they tried the Nazis. You cannot stage that. God staged that, and God, it turns out, is a better satirist than any of us. She did not phone us. She did not post. No prime minister demanded it for her on the internet. She had, as far as our deliberations are concerned, the one qualification the loud man could never manufacture, which is that she wanted the work and not the medal. The medal finds those people. It flees the ones who chase it. This is not a rule we wrote. It’s just the only pattern the hundred-odd years of our mistakes has ever shown. The reaction from across the ocean was immediate. His spokesman posted that we “place politics over peace.” Ja. Perhaps. We’re five damp pensioners in a rainy city; of course it’s political, it was always political, it was political when we gave it to a sitting American president nine months into his first term for the promise of things he had not yet done, and we have been quietly embarrassed about that one for fifteen years, so believe me, we had a particular reason this year to prefer a woman with fifty years of verdicts behind her over a man with eight wars in front of him and a deadline already behind him. Here is what he will never understand, the thing I’d tell him on the tram if he ever took one. We are the one prize he cannot buy, cannot post his way to, cannot have a friendly dictator phone in for him. Not because we’re incorruptible, nei, we’re as vain and wrong and human as the portraits on our wall. But because the entire point of the thing, the only power a small cold country’s book club has ever held, is that it goes to the person not performing the wanting. The moment you demand it, you’ve proven you don’t understand what it’s for, and proving that is itself the disqualification. He ran the most expensive campaign in the history of the prize and the campaign was the reason. He was never losing to Navi Pillay. He was losing to the concept. It’s dark now. Four o’clock dark. The buns are gone. Kristin said “well” an hour ago and we all went home. I’m on the tram with my wet shoes, and somewhere across the water a very powerful man is explaining to a camera that the prize is rigged, that we’re corrupt, that he’ll win it next year, and he genuinely might, we’re only five idiots and we’ve been wrong before, Kissinger is still on the wall. But not this year. This year an old woman in Nuremberg, in the room where the law once stared down the exact kind of man who thinks wanting a thing loudly enough should make it his, got a phone call she didn’t ask for. That’s the job. We don’t reward the man who ends the war and announces it. We reward the woman who spent fifty years deciding what a war was. He’ll never see the difference. That’s rather the whole point of him. Takk for i dag. I have to change trams.
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Axel Grothey retweeted
I created a font called Ghost Font that only humans can read. Tested it in Fable and GPT 5.6 Sol Ultra and neither was able to decipher it correctly.
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Tony Fauci was in charge of an agency that funded research which allows us to develop vaccines in 10 months. Kennedy cancelled that research and is responsible for thousands of preventable deaths
Thank you, Tulsi, for documenting Dr. Fauci's central role in causing the COVID-19 pandemic — among the most consequential crimes in human history.
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Axel Grothey retweeted
Results from a phase 2a study of atebimetinib in combination with mGnP in advanced or metastatic pancreatic cancer 👉ORR , mPFS 8.3, mOS 17.3 🧐Intersting data, targeting RAS/MEK is moving forward, phs-3 ongoing @myesmo @ASCO
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Cheers, chills, and a standing ovation when RASolute 302 showed unprecedented survival on daraxonrasib for patients with progressive pancreatic cancer Seldom do you sense you’re witnessing a historic moment in cancer care but this feels like ras targeting has arrived #ASCO26
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Axel Grothey retweeted
Standing ovation for the RASolute302 trial results! @UTMDAnderson @KRASKickers #ASCO26 @RevMedicines
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Axel Grothey retweeted
Presented at #ASCO26: Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: nej.md/4nWaxvM @ASCO
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#ASCO26 has released most abstracts. I will break down GI cancer-related abstracts to five tables: Important studies Interesting studies Important negative studies Novel agents Practice re-affirming studies Abstracts that have not been released but are eagerly anticipated: RASolute-302, EMERALD-3, CIRCULATE (AIO), Episode-3, BREAKWATER update, PUMP. Please see the tables below for the first two tables (important studies, interesting studies). More to come. @OncoAlert @jgong15 #GIcancer
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Axel Grothey retweeted
Revolution Medicines Statement on FDA Expanded Access Authorization for Daraxonrasib in Patients with Previously Treated Metastatic Pancreatic Cancer ir.revmed.com/news-releases/…
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