@airdlab

My lab studies the interplay between cancer metabolism and cell cycle dysregulation. Professor. The Wistar Institute

 Philadelphia, PA
airdlab.com
Joined May 2017
  • Tweets4.6K
  • Following2.4K
  • Followers4.6K
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Our lab is expanding and hiring both a postdoc and staff scientist! We study how metabolism and cell cycle states drive tumor progression, therapy response, and immune interactions. Philly is a great place to live and do research! See more at: airdlab.com.

Aird Lab

airdlab.com
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Katherine Aird retweeted
Hsieh Lab@HsiehLabOct 7
Ever wonder if tRNAs can regulate the identity of a cancer cell? @HsiehLab @FredHutch postdoc @yeonsookim_phd did and discovered a single tRNA that can control lineage dependency and drug sensitivity in prostate cancer published today @Nature: nature.com/articles/s41586-0…

tRNA dosage regulates lineage dependency and resistance in prostate cancer

Nature - A tRNA-specific regulatory pathway is associated with codon biology, lineage transitions and therapy resistance in prostate cancer.

nature.com
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Katherine Aird retweeted
Manuel Collado@mcollado_CIMUSSep 24
Our latest paper has just been published in @Aging_Cell 🥳 onlinelibrary.wiley.com/doi/… Extracellular vesicles (EVs) from senescent cancer cells are not just passengers of the SASP. They are both necessary and sufficient to spread senescence to neighboring cells 🧵

Extracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine...

Senescent cancer cells exhibit a secretory phenotype, known as SASP, capable of inducing paracrine senescence. However, the main factors within the SASP triggering this process are unknown. Here, we...

onlinelibrary.wiley.com
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Katherine Aird retweeted
Joel Boerckel@jboerckelSep 9
Our latest preprint, from @eerinberr is live: Cytoskeletal disassembly by optogenetic control of RhoA signaling termination. biorxiv.org/content/10.64898…
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FrezzaLab@FrezzaLabAug 18
I am extremely proud to share this paper from @_Christina_Sch "Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz" in @JulioSaezRod ! Congratulations to all involved! link.springer.com/article/10…

Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz

Molecular Systems Biology - The lack of standardised workflows and ambiguous metabolite annotations hampers metabolomics integration with prior knowledge, thus limiting the extraction of meaningful...

link.springer.com
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Replying to @TwistBioscience @davidrliu
From @airdlab and team: “The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming” nature.com/articles/s43587-0…

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic...

Nature Aging - Cole and colleagues identify fructose as a component of the secretome in therapy-induced senescent ovarian cancer cells that drives metastasis. Fructose metabolically reprograms...

nature.com
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Katherine Aird retweeted
April Watt@AprilCWattAug 13
Excited to share our work, now in @Nature! Delighted to have co-led this study with co-first author @AntonioAhnNZ under the supervision of @shomgoel at @PeterMacCC @PeterMacRes and the University of Melbourne @uommedia Open access: nature.com/articles/s41586-0…

Rb-driven transcription limits its tumour-suppressive effects in breast cancer

Nature - CDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.

nature.com
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Immune surveillance and immune evasion of senescent cells dlvr.it/TTyX7y

Immune surveillance and immune evasion of senescent cells

Nature Reviews Immunology - This Review outlines the context-dependent mechanisms that determine the immune surveillance or immune evasion of senescent cells and how targeting these immune-mediated...

nature.com
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Katherine Aird retweeted
Nechemia-Arbely Lab@ArbelyYaelAug 10
Our new paper is out in @CellReports 🎉 Congrats to @MahlkeMegan, and the whole team and collaborators! Check it out here: cell.com/cell-reports/fullte…

Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and...

Mahlke et al. find centromeres and neocentromeres display heterogeneous, plastic CENP-A and DNA methylation patterns within populations. Unlike centromeres, neocentromeres lose DNA methylation...

cell.com
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Katherine Aird retweeted
Twist Bioscience@TwistBioscienceAug 3
The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming Thank you to the @airdlab & team for choosing Twist DNA to support this research! nature.com/articles/s43587-0…

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic...

Nature Aging - Cole and colleagues identify fructose as a component of the secretome in therapy-induced senescent ovarian cancer cells that drives metastasis. Fructose metabolically reprograms...

nature.com
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Katherine Aird retweeted
Cancer Discovery@CD_AACRJul 29
Acquisition of Centromeric Features Supports Telomere Integrity doi.org/10.1158/2159-8290.CD… A #ResearchWatch summary of a recent study by Ragini Bhargava, Yael Nechemia-Arbely, Roderick J. O’Sullivan, and colleagues.
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Check out the press release here: wistar.org/press-releases/wi…

Wistar Scientists Identify Fructose as a Surprise Driver of Cancer Spread

Wistar Scientists Identify Fructose as a Surprise Driver of Cancer Spread Press Releases

wistar.org
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We are grateful that this work was supported by @theNCI, CDMRP, @UPMCHillmanCC, @PittTweet, @TheWistar
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Also big thank you and congrats to all coauthors and collaborators. @BioYupi @ApoorvaUboveja @mzspectrum @NadineHempel @CoffmanLab @oesterreichs @healthspan_AUG @zervanto and many others!
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Huge congratulations to first author Aidan Cole. He is brilliant, an awesome person, and currently looking for an industry position. Reach out if you have any leads- he’ll be the best colleague!
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