@allardlab

Mathematical and computational biology lab for studying cell and molecular mechanics at UC Irvine. Account run by Jun & grad students.

 UC Irvine
allardlab.com
Joined January 2020
  • Tweets96
  • Following71
  • Followers157
27Media
Welcome to the 2026-2027 Seminar Series! We are pleased to host researchers from institutions across the world, including @Stanford, @tcddublin, @harvardmed, and more > bit.ly/4waU5ue 2nd Wednesdays @ 2PM ET | Schermerhorn Hall 603 & Zoom
image card of the 2026-2027 IICD seminar series, with headshots of each speaker

ALT image card of the 2026-2027 IICD seminar series, with headshots of each speaker

2
1
4
530
Now in print at Biophysical Journal @BiophysJ @bryochemist! sciencedirect.com/science/ar…
allardlab@allardlab3 Dec 2025
Replying to @allardlab
Many reactions in cells are tethered, often by #IDR. If 2 tethers are tied together (imagine handcuffed arms ⛓️‍), does this enhance or suppress their reactions? Formin, one of the major #cytoskeleton builders in eukaryotes, does exactly this.
1
1
91
Brady's work is published this week in Biophysical Journal! Mathematical link between cell mechanics and percolation theory cell.com/biophysj/fulltext/S…

Astral architecture can enhance mechanical strength of cytoskeletal networks by modulating percol...

A repeated pattern in cytoskeletal architecture is the aster, in which a number of F-actin filaments emerge star shaped from a central node. Aster-based structures occur in cytoplasmic actin, the...

cell.com
1
57
Review article with Omer Dushek @Dushek on tethered signaling proteins, out now! Tethered bio-molecular reactions can do at least 7 cool things that freely-diffusing reactions do not. Read more here! #IDR #TCells #cytoskeleton annualreviews.org/content/jo…
2
16
855
Katie Bogue's new preprint with Margot Quinlan and Bryan Christian, out now! biorxiv.org/content/10.1101/…

Impact of N-terminal dimerization on formin homology 1 domain polymer dynamics and actin assembly

Many proteins contain intrinsically disordered regions (IDRs) that lack stable 3-dimensional structure. IDR behavior is poorly understood, leading to challenges for biochemical and computational...

biorxiv.org
1
35
Many reactions in cells are tethered, often by #IDR. If 2 tethers are tied together (imagine handcuffed arms ⛓️‍), does this enhance or suppress their reactions? Formin, one of the major #cytoskeleton builders in eukaryotes, does exactly this.
1
125
Very excited to be involved in this new work led by Junhao Gu and Elizabeth Read, out this week in Bioinformatics. Collaboration with @timothy_lamont, @ChrisEMiles and others! academic.oup.com/bioinformat…

Scalable inference and identifiability of kinetic parameters for transcriptional bursting from...

AbstractMotivation. Stochastic gene expression and cell-to-cell heterogeneity have attracted increased interest in recent years, enabled by advances in sin

academic.oup.com
1
1
90
A remarkably simple question, "What is the likelihood landscape for the basic bursting transcription model?", reveals surprisingly complex underlying structure, with implications for the limits of what single-cell data can tell you.
20
We can make the flexibility of a model match the hypothesis being tested -- more flexibility is not always better, if it prohibits rejection of the hypothesis. Here is one simple case involving T cells where it made a difference! biorxiv.org/content/10.1101/…
29
Our paper with with @timothy_lamont and @ASpakowitz is out in Nucleic Acids Research! academic.oup.com/nar/article…

Nucleosome placement and polymer mechanics explain genomic contacts on 100 kb scales

Abstract. The 3D organization of the genome—in particular, which two regions of DNA are in contact with each other—plays a role in regulating gene expressi

academic.oup.com
1
1
108
Brady's preprint on astral cytoskeletal structures is on biorxiv! A surprising connection between percolation and asters, and another example where an optimal choice aligns with the cell! biorxiv.org/content/10.1101/…
38
Jack's preprint with @timothy_lamont and @ASpakowitz is out on biorxiv! biorxiv.org/content/10.1101/…
1
1
2
1,329
Small changes in nucleosome placement -- even at approximately the same average frequency, even ~100kbp from the loci -- can drive contacts between TF binding motifs and gene promoters.
1
86
Polymer mechanics modeling, ATACseq, EM, 4C-seq working together to explain 3d genome organization. The most surprising thing to me is the continuing high predictive power of models fairly few, fairly simple biophysical factors.
72
Group dinner, including our colleague Jin Yu, some alumni, and two years' worth of amazing @UCI_CMCF high school researchers!
1
86
We generate a song for every group meeting now.
Omer Dushek@Dushek25 Sep 2024
We are very pleased to announce that our colleagues @allardlab have kindly produced a fantastic summary of our EMBO Journal manuscript in the form of AI-generated Korean Pop! @embojournal embopress.org/doi/full/10.10…
90
allardlab retweeted
Omer Dushek@Dushek25 Sep 2024
We are very pleased to announce that our colleagues @allardlab have kindly produced a fantastic summary of our EMBO Journal manuscript in the form of AI-generated Korean Pop! @embojournal embopress.org/doi/full/10.10…
3
3
2
21
3,572
Lab dinner
1
5
587
Attention biomechanics & mechanobiology folks! We are super-excited to announce that we will be hosting the next MechBio Symposium @CUBoulder @BioFrontiers on April 6-7, 2024! Please visit tinyurl.com/cumechbio24, save the date, and fill a short information form. RT+amplify 1/N
1
15
3
40
10,940
UCI crew
1
3
21
2,057
Load more