Scientist at @harvardmed and @WyssInstitute in @geochurch's lab | Working on solving aging

Joined October 2019
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Alex Plesa retweeted
Announcing Ikigai Grants: Microgrants give early-stage, bootstrapped talent capital. But that’s not enough. I’ve watched too many grantees become perpetual microgrant chasers, wasting time applying to one $5k grant after another. Worse, most programs encourage this by funding the blanket “smart people doing cool things,” with no real conviction behind it. I wouldn’t be here without patronage from @tylercowen & @jposhaughnessy. But looking back, the mentors & community were worth much more than the money. So I built the program I always wished existed: - $50k total, avg. $5k check - Matched with mentors & community across @RenPhilanthropy , Fulcrum Science, and my personal network of founders, fund leads, investors & scientists. Cohort 1 backs emerging talent in areas I believe are deeply underfunded and undervalued. Every application is reviewed by me. Ikigai Grants is a program of @RenPhilanthropy, with support from Fulcrum Science. Advised by many wonderful friends & colleagues including: @AshleyNAbel @RaianyRomanni @NeuroStats Bonnie EJ Maven @idatin @ashleyz413 @JackScannell13 Apply by Nov 9th, 9a PST: alexaraki.xyz/ikigai
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Replying to @ShorterLab
Thanks for sharing. Free to read here: rdcu.be/ypTLcckieF8a
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Replying to @MichaelFloreaX
Thanks Michael! Looking forward to seeing what you've been up to at Olden.
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Replying to @gonzaloruizutri
Thanks! The frailty readouts are in the paper (~44% slower accumulation). We didn't measure grip strength this time, but we'll consider it for the next one.
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No. The team handling the mice was blinded to group assignment until one group had completely died off, and the frailty index was graded by a blinded reviewer every 2 weeks throughout. We unblinded after that point and kept measuring until the last SRSF1 mouse died.
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Unsure on embryonic neural-SRSF1 is ubiquitously expressed. Constitutive overexpression transforms immortalized cells, but we used moderate pulses and mice lived longer (no tumor data). I think SRSF1 promotes regeneration, predisposing cells to transformation in the right context
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