@amtdutt

Exploring the landscape of genetic alterations in cancer through genomics, computation, and functional analysis. Prof @ Dept of Genetics, UDSC @UnivofDelhi

 New Delhi
amitduttlab.com
Joined March 2018
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1/n Thanks to NAR Cancer @NAR_Cancer_EIC, for publishing our recent finding along with Dr. Sudhir Nair @ACTREC_TMC doi.org/10.1093/narcan/zcac0…. We have a long-standing interest in studying pathogens associated with human cancer.@India_Alliance @DBTIndia @the_hindu @RPrasad12
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Our work in collab with Dr. Sudeep Gupta, @TataMemorialCtr explained lucidly by TOI and IE. Congratulations to @Suhail_Shaad and the entire team for this important contribution! We thank @DBTIndia for support, as well as UDSC @Delhiuniversit & @CRI_ACTREC lnkd.in/gxhgk-um
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Pleased to share our study led by @Suhail_Shaad on endocrine resistance in HR+ breast cancer @UnivofDelhi & @CRI_ACTREC. Loss of CDKN1B (p27) disrupts ER signaling, drives resistance, yet tumors retains sensitivity to CDK4/6 inhibitors. Thanks @DBTIndia nature.com/articles/s41416-0…
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Ph.D applications at @UnivofDelhi is open. Last date for applying is Mar 24th. You may register and apply here: phd-ph2-2025.uod.ac.in/index…
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Pleased to share an imp study on AI resistance in HR+ breast cancer--led by Suhail in my lab @UnivofDelhi & @CRI_ACTREC! We show insulin sig' mutations, ESR1 upreg', and a novel ESR1-PPP3CA fusion: new therapies to overcome resistance. Thanks @DBTIndia sciencedirect.com/science/ar…
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Pleased to share our twin study (back-2-back), by Vaishakhi Trivedi from K Prabhash gp, @VanitaNoronha , my lab @CRI_ACTREC/@ACTREC_TMC & Dept of Genetics @UnivofDelhi on papillary and anaplastic thyroid ca. sciencechronicle.in/2025/07/… ascopubs.org/doi/10.1200/GO-… ascopubs.org/doi/10.1200/GO-…
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Can microbe DNA in blood reveal lung cancer? biopatrika.com/academia/rese… Thank you @biopatrika for highlighting the work of Vichitra Behel and Supriya Hait from Kumar Prabhash's lab @TataMemorial and my lab at @UnivofDelhi / @CRI_ACTREC in collab with @1cellAi and @4baseCare
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Pleased to share our study led by Dr. K Prabhash, @VanitaNoronha from @TataMemorial, and me from @UnivofDelhi in collab with @1cellAi & @4baseCare where we found… nothing! Published in NPJ System Biology & Applicant (@Nature_NPJ). nature.com/articles/s41540-0…
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10 of n: Offnote, efforts from research groups have shown plasma microbiome signatures as a promising approach in detecting colorectal, pancreatic (metagenome-based) & lung cancer (WGS-based). Our study, along with others, however, suggests several more nuances to be overcome.
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11 of n: We emphasize the need for stringent bioinformatics approaches to ensure accurate cancer microbiome profiling from liquid biopsy. Thanks to ICMR (@ICMRDELHI), DHR (@DeptHealthRes) for the funding. And,@DAEIndia for the transformative agreement with @SpringerNature for OA.
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8 of n: We thus concluded that under our experimental set up neither CGP nor WES — in their current form — can reliably detect a microbial DNA signature in plasma to identify lung cancer. But this study is still relevant.
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9 of n: It highlights key limitations in our study: low microbial DNA abundance, risk of overestimation by standard tools, need for better microbial enrichment, and cleaner databases. So we now know what not to do — and that’s a crucial lead!
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