@andreafava

Rheumatologist and physician scientist @JohnsHopkins 🇮🇹🇺🇸| Studying mechanisms of #Lupus | Immunology | Computational biology

 Baltimore, MD
Joined January 2010
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  • Following519
  • Followers555
24Media
Our new studies show that neutrophils increase in the urine of #lupus patients with active skin disease, in LN kidneys, and after skin exposure to UV, promoting renal tissue remodeling. @J_Immunol @andreafaa @GeiselMed @DartmouthHealth @MCBDartmouth academic.oup.com/jimmunol/ar…

A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodel...

Abstract. Neutrophils have been implicated in mediating immune crosstalk between injured tissue and distal organs, either promoting local and distal inflam

academic.oup.com
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Urine biomarkers capture molecular responses in lupus nephritis, and may reshape how we assess treatment response. In TULIP-LN, anifrolumab significantly reduced urinary biomarkers of histologic activity by Week 12, even in proteinuric nonresponders. 📄 doi.org/10.1002/art.70089

Anifrolumab Treatment Leads to Rapid Reduction in Urinary Biomarkers of Intrarenal Inflammation in...

Objective Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon signaling. Anifrolumab, an approved treatm...

acrjournals.onlinelibrary.wiley.com
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So excited to share our latest with Betty Diamond and many colleagues from the AMP RA/SLE consortium, @NIH_NIAMS , and @NIAIDNews ! A large-scale blood and tissue atlas of Lupus Nephritis! biorxiv.org/content/10.1101/…

A population-scale atlas of blood and tissue in lupus nephritis

Lupus nephritis (LN), a severe manifestation of Systemic lupus erythematosus (SLE), is a heterogeneous disease driven by diverse immune and tissue cell types. Current treatments of LN are non-speci...

biorxiv.org
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NEW Correspondence—Preload deficiency as a treatable cause of fatigue and exercise intolerance in #SLE bit.ly/3URufuM
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Preload deficiency as a treatable cause of fatigue and exercise intolerance in SLE - The Lancet Rheumatology thelancet.com/journals/lanrh…

Preload deficiency as a treatable cause of fatigue and exercise intolerance in SLE

Fatigue and exercise intolerance affect more than 90% of patients with systemic lupus erythematosus (SLE), often persisting despite inactive disease.1 The pathophysiology of the disease remains...

thelancet.com
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Replying to @YooJinKimYJK
@YooJinKimYJK led our @hopkinsheart + @andreafava @HopkinsRheum team in investigating recurrent pericarditis in Lupus. Oral prednisone therapy increased recurrence risk. Further evidence that prednisone should be minimized in lupus?⁦@JAMANetworkOpen⁩ jamanetwork.com/journals/jam…
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Andrea Fava retweeted
Dr. John Cush
@RheumNow15 Jul 2024
268/279 SLE pts w/ kidney biopsy for proteinuria were Dx w/ lupus nephritis. Proliferative LN (III/IV+V) had higher levels of C1q, chromatin, dsDNA, ribosomal P Abs. C1q & dsDNA independently assoc w/ proliferative LN. AutoAbs decreased in proliferative LN buff.ly/4cCQCvf
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Levels of anti-C1q and anti-dsDNA were independently associated with proliferative lupus nephritis In proliferative LN, higher baseline anti-C1q levels predicted complete response better than baseline proteinuria In A&R loom.ly/OXIzDVI
Association of autoantibody concentrations and trajectories with lupus nephritis histological features and treatment response. Graphical abstract created with BioRender

ALT Association of autoantibody concentrations and trajectories with lupus nephritis histological features and treatment response. Graphical abstract created with BioRender

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Tomorrow #preprintHub1 @nicolas_ruffin from @karolinskainst will present a #preprint by @luigiadamomdphd lab showing how B cell-mediated antigen presentation promotes adverse cardiac remodelling in chronic heart failure 🫀🩺👷‍♀️ biorxiv.org/content/10.1101/…

B cell-mediated antigen presentation promotes adverse cardiac remodeling in chronic heart failure

Cardiovascular disease remains the leading cause of death worldwide. A primary driver of cardiovascular mortality is ischemic heart failure, a form of cardiac dysfunction that develops in patients...

biorxiv.org
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Andrea Fava retweeted
Dr. John Cush
@RheumNow1 May 2024
Low urinary IL16 levels at 12 months predicts kidney survival at 3 years better than proteinuria - @Andreafava @rheumnow #RNL2024 buff.ly/3UEdOmc
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🔬 Exciting news in #Lupus! Our latest study is out. Discover how urinary biomarkers can transform lupus nephritis diagnosis & guide treatment. Plus novel insights into disease mechanism 🚀🚀. Dive into the research here buff.ly/48JqcGg #Rheumatology #Nephrology
JCI insight
@JCI_insight30 Jan 2024
Urine proteomic signatures of histological class, activity, chronicity, and treatment response in lupus nephritis: buff.ly/48JqcGg @andreafava @HopkinsMedicine #Nephrology
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Thanks to @FNIH_Org, @NIDDKgov , @NIH_NIAMS, @LupusOrg, @LupusResearch, the Jerome L Greene Foundation, and the Plank Foundation for their support to this work and its future development!
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Urine proteomic signatures of histological class, activity, chronicity, and treatment response in lupus nephritis: buff.ly/48JqcGg @andreafava @HopkinsMedicine #Nephrology
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Wonderful presentation by @celia_ida on a possibly novel cell type implicated in lupus nephritis #ACR23 #ACRBest
Eric Dein@ericdeinmd14 Nov 2023
A#2427 #ACR23 @RheumNow PR3+ cell abundance higher in prolif LN, more than membranous. Mostly in tuberulointerstitium Density of PR3+ higher in glomueruli of prolif LN Correlates with activity, not chronicity Urinary PR3 predict renal fxn loss at 3y @jhrheumatology @andreafava
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Honoured to receive this award! Huge thanks to @LupusAcademy for the opportunity and gratitude to my mentor @andreafava for guiding me every step of the journey! 🙏🏻#grateful #AwardWinning
Lupus Academy@LupusAcademy10 Sep 2023
Congratulations to the Poster Oral Presenters. The reviewers praised all of them, with the final prize going to Alessandra Ida Celia #lupus2023
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Andrea Fava retweeted
Lupus Hub
@lupus_hub2 Jun 2023
CONGRESS #EULAR2023 | @andreafava presented data on urinary biomarker levels at 3 months predicting treatment response at 12 months. CD206, CD163 and IL16 better predict treatment response in proliferative LN than proteinuria. #Lupus #lupusnephritis
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‼️ Application Opening ‼️ Join us as a postdoc #T32 research fellow in the Division of #Rheumatology! Learn more: hopkinsrheumatology.org/T32
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Kicking us off this morning: Many of our @HopkinsMedicine rheumatologists are presenting during the #ACR22 virtual and in-person poster sessions starting at 9am. Join @BritAdlerMD @andreafava @ZsuzsMcMahanMD @CaoilfhionnMD and others.
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Find out about recent efforts to deliver more targeted & effective #rheum treatments during a session at #ACR22. Read a preview in ACR Convergence Today → acr.tw/3fVs8Fw @andreafava
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#Hiring Join our research @HopkinsRheum to discover new treatments and molecularly redefine kidney #lupus using many omics? Computational only or hybrid with wet lab experience. Fun guaranteed. Physician-scientists most welcome. T32. DM me! @LupusOrg @RheumResearch
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