Biodrug design @ AI ∩ biology

In Silico & In Vivo
Joined November 2008
Andrés Miguel Torrubia Sáez retweeted
The biggest risk for a successful company is believing that what made it successful will keep working forever. It took Freepik 12 years to grow from scratch into a large, successful business. It was a remarkable journey. We had millions of users and were competing with the biggest players in the stock content industry. Around 4 years ago, when Dall-e 2 was released, I was with @cuenca at a founders event in Malaga and he told me he couldn’t sleep for days thinking about how this was going to change our industry. It was going to redefine how creative content is produced, distributed, and consumed. Many in our user community hated AI-generated content. Our competitors were suing AI model providers. And our business was doing incredibly well. Still, we went all in on AI. We decided to transform Freepik into an AI-native company. Freepik became @magnific. And in less than three years, we grew the business 10x. Shutterstock, once one of the giants of stock content, has seen its market capitalization collapse from over $4 billion in 2021 to approximately $170 million today. Getty Images, another iconic name in our industry, filed for Chapter 11 bankruptcy protection last week. For decades, the creative industry was built around distributing existing content. Now, increasingly, it’s about generating entirely new content. That represents a fundamental shift in where value is created. And when that happens, being an established market leader can become a disadvantage if you’re too attached to the business model that got you there. We didn’t reinvent Freepik because it was failing. We reinvented it precisely because it was successful, and we wanted to make sure it stayed that way. Today, Magnific is a very different company from the one we were three years ago. And I suspect we’ll be a very different company three years from now. Your past success is an asset. Until you start treating it as something you need to protect.
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Andrés Miguel Torrubia Sáez retweeted
Tengo una entrada para la @tarugoconf . Me gustaría regalarla a algún estudiante o alguien esté en el paro y no se lo pueda permitir. Que nunca haya ido. Pero que vaya a ir. Sé que es muy justo. Es este jueves/viernes. Es un evento muy especial y ya que puedo acudir me gustaría
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Andrés Miguel Torrubia Sáez retweeted
8 días para la @tarugoconf Ayer, por fin, revelamos en nuestra web la identidad del último ponente por confirmar de la #trg26: el awesómico @antor abrirá el evento con su keynote, titulada «La odisea del programador».
9 días para la @tarugoconf En la #trg26 volvemos a contar con la colaboración de @mundohr. Para los gallegos, más que una empresa, una seña de identidad. Este año no solo tendremos Estrella Galicia sino también Amara Brava (spritz) y, en la fiesta, su vodka Vanagandr 🥳
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Andrés Miguel Torrubia Sáez retweeted
At the 2015 Breakthrough Pize, Yuri Milner asked: "Do you imagine, maybe in 100 or 1000 years, that like what happened in chess when computers took over...is it conceivable that this will happen in mathematics?" Tao: "I think we will use computers to do things much more efficiently, but it will still be humans driving the show, I'm pretty sure" Kontsevich: "I think it's perfectly possible in our lifetime, yes. I don't think artificial intelligence is pretty hard, so it will be pretty soon I suppose, yeah" youtube.com/watch?v=eNgUQlpc…
👀 Ok this is very interesting, per Maxim Kontsevich: "The AI agent then proposed me a better definition of what I'm doing, so I'm shocked" youtube.com/watch?v=c_VFKWs4…
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"Trust but verify" is a must when using LLMs.
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“Cryptography is a subfield that’s extremely conspicuous by its absence from OpenAI’s list of 376 papers! But my sources tell me that the AI cos have now started, gingerly and discreetly, investigating whether their latest internal models can break important cryptographic protocols and primitives.” - Scott Aaronson, CS chair at UT Austin
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Andrés Miguel Torrubia Sáez retweeted
The thing the Ai tech bros don't understand about biological research is WE WANT YOU TO CURE DISEASES. No one is against you trying, but PLEASE realize its waaaay harder than anything you have ever done, by orders of magnitude and it WILL grind your ego to dust Do it tho. Please
I checked all 722 papers and 0 cancers were cured among them. Cancerbench remains unsolved.
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Andrés Miguel Torrubia Sáez retweeted
This is MASSIVE: Biohub just announced a $1.8 billion effort to build open datasets for virtual cells. And look at the partners: Google DeepMind. Isomorphic Labs. Meta. The US Department of Energy. The National Institutes of Health. The data is intended for scientists worldwide to use. I have followed this initiative since its launch in April. Here’s what you need to know. 🧵 (1/7)
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Andrés Miguel Torrubia Sáez retweeted
AI development at Anthropic:
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Andrés Miguel Torrubia Sáez retweeted
A call to all entrepreneurs, founders, small business owners in Europe and anyone else who aspires to star a company at some point. This is the moment to act and let your voice be heard on EU Inc. EU Inc is the proposed legislation to make it easier to start and grow a company across Europe. It is now in front of the European Parliament and also being negotiated by governments. The objective should be very clear: you should be able to start and grow your company in Europe as your home market. What this should mean is, I think, at a minimum this: 1, You should be able to start a company online and cheaply. 2. You should be able to have a simple registration that you can fill out by yourself, with secure identity checks built in. You should not be forced to hire and pay a notary for this process. 3. The basic rules should be the same across Europe and should be common. There should be one registry with common rules and you shouldn't have to go to the lawyers of each country to set up different subsidiaries. 4. There should be a simple way to give employees a share in what they are helping you build, through stock options. They should only pay the tax when they sell those shares and when they receive the money. 5. The paperwork should be much simplified. There should be one channel for doing the VAT across borders and use the time saved to do your job and not to do paperwork. 6. The rules should support the entire life of the business; raising money, growing, going public, and also liquidating a failed business should all be done under the European common rules. Opening a bank account in another country, hiring across borders should be seemless. The European Commission made an initial proposal that was not sufficiently ambitious in my view but that was a useful start: it had online registration in 48 hours for less than €100 and measures to facilitate the taxation of employee stock options. It had some rules on common liquidation of the companies. In my view it was not ambitious enough because it allowed national authorities to impose further requirements, such as notaries. It was already falling short on tax and employment, but the reforms that the other institutions are introducing are making it even less ambitious. The draft that is being discussed by the governments eliminates the European company register and replaces it with a website that is just a portal to underlying national systems. This does not improve the creation of companies in any way. They're also eliminating the common procedures to liquidate failed companies, which was very useful because it facilitates the financing of these companies. The danger in the legislation is that it will require so many national exceptions that the founders will, in fact, end up facing still all the different regimes and it will make absolutely no difference. What I suggest here is that you write to your member of the European Parliament this week. Tell them about the obstacles your business is facing: the paperwork, the difficulty of giving shares, of raising money across borders. Explain what it costs and why it makes it difficult to create employment. Ask them what they will do to help you to make this legislation useful. Your MEPs work for you. Here are their contact details: competecentre.eu/the-launch-… The MEP leading Parliament’s work is René Repasi. The other political-group negotiators are Axel Voss, Pascale Piera, Mario Mantovani, Pascal Canfin, Sergey Lagodinsky, Kira Marie Peter-Hansen, Arash Saeidi and Marcin Sypniewski. Share this with other entrepreneurs. Help make sure that the people writing the law hear from the people that the law is meant to help.
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Andrés Miguel Torrubia Sáez retweeted
5 years ago I was working on LLMs because I believed in them. And yet I didn't think we'd get where we are today without a major paradigm shift. I definitely didn't expect things to move so fast. I was wrong. It's astonishing to see some of the very vocal people who were far more skeptical than I was insist that they were right all along, because "hey, today's models do a lot more than predict the next token." Like, sure, coding agents can run commands in a terminal. But they do it by predicting the next token. What in the world did you expect? No one was claiming that LLMs would solve every problem without any way to interact with their environment. But the layer on top is very thin, and tool use isn't a new paradigm. "Giving BERT a Calculator" came out 7 years ago. Science is about updating your beliefs based on evidence. Admitting that your view has changed doesn't make you a worse scientist. It makes you a better one. This obsession with "I've been saying the same thing for X years and I was right all along" is so tiresome, and sets a terrible example for the general public and the new generation of scientists.
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Would you give your competitors a non-exclusive, worldwide, royalty-free, perpetual and irrevocable for your design of a frontier drug development problem? That's what Anthropic wants: Anthropic went from outright banning any drug development efforts using their models, to starting their own drug discovery pipeline, building a wetlab, and sponsoring competitions... THANKS BUT NO THANKS
We're launching Challenge 1 of the Anthropic x Adaptyv Protein Design Competition on @proteinbase: design a conditional binder to EGFR, a key cancer target. The goal: bind EGFR under the acidic conditions of the tumor environment, but not at the normal pH around healthy cells. Moreover, the proteins must bind to both the human and the mouse variant of EGFR to support easier preclinical testing
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POETRY
A Flock of Altruists - Hit The Breaks Except For Me
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Andrés Miguel Torrubia Sáez retweeted
"No están confesando, están fardando" El debate sobre el momento de frenar la inteligencia artificial, los argumentos de Anthropic y OpenAI y su credibilidas, el impacto en las empresas y mucho más con los grandes @antor y @mangelroman :
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Andrés Miguel Torrubia Sáez retweeted
Godmother of AI and World Labs CEO Fei-Fei Li says the real existential threat was never AI: "Any threat to human society, including existential, is within ourselves."
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The EU mind cannot comprehend
i will die happy when we can do this in america
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Andrés Miguel Torrubia Sáez retweeted
- Germanic, ‘earn/deserve’ money: a moral weight from working - American, ‘make’ money: new wealth is created, not a fixed pie - Latin: ‘win’ money: you gain by taking it from others, zero-sum fixed pie No comment is even needed on this one
"Only the German language calls earning money verdienen ('to deserve it' through effort). The French and Spanish 'win' ( ganar ) it, the English 'harvest' ( earn ) it, Americans 'make' ( make money ) it, and the poor Hungarians 'search' for it.
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