Scientist I @Biohub at Mahat lab | postdoc at Lareau lab @MSKCancerCenter | Ph.D. @IcahnMountSinai | B.S. @UCMerced | protein design/drugdiscovery/singlecellseq
Joined April 2020
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Arthur Chow retweeted
Sequence and structural determinants of efficacious de novo chimaeric antigen receptors go.nature.com/4dm4Seb
Finally out today!
TLDR for folks who read the preprint. Our new in-vivo data blew my mind. The designed binder outcompeted the FDA approved ones in challenging scenarios 👀
Fantastic way to close out my time in @CalebLareau’s lab. There's lots more to be done in this space.
Three years ago, my lab at @MSKCancerCenter set out to see if we could harness AI for new therapeutic proteins.
Today in @natBME, our first step in developing these AI-designed molecules as anti-tumor therapies is online.
Read more here: 1/n mskcc.org/news/using-ai-to-d…
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Arthur Chow retweeted
We’re unwrapping a new method today @MSKCancerCenter!
Led by @SydneyBlattman, @NabihMaslah, @AustinAVarela, Ronan Chaligne and @dana_peer, plus colleagues at @10xGenomics, we’re delighted to share Genotyping In Fixed Transcriptomes (GIFT):
biorxiv.org/content/10.64898…
1/n
Really enjoyed speaking today about our work on the dos and don’ts of de novo protein design for immunotherapy w/ @hoyin_chu. Grateful for the invitation to this awesome seminar series.
Arthur Chow retweeted
⚠️ If you’re reading this, you’ve been infected* ⚠️
*~95% the human population has been infected by the Epstein-Barr Virus (EBV).
Today in @Nature with @nyeo_sherry, @EMC22381830, @RyanDhindsa @SlavePetrovski, we shed some light on what happens next.
nature.com/articles/s41586-0…
Extremely proud of the work our team put together and grateful to everyone who made this possible as it heads out into the world. Huge thanks to @CalebLareau and @hoyin_chu for tackling this fun scientific adventure with me.
Excited to share the first preprint of a new direction for our group. Led by the fearless duo of @arthurwchow and @hoyin_chu, our foray into computational protein design— 1/n
biorxiv.org/content/10.64898…
Arthur Chow retweeted
Building CAR-T 🏎️ cells from scratch - not borrowed parts. In @CalebLareau’s lab, @arthurwchow is designing custom binders from scratch + stress-testing them in record time - engineering CAR-Ts built to win the race against cancer 🏁
ALT Arthur Chow, PhD Lareau Lab/ Computational and Systems Biology Constructing a Formula One champion CAR (T-Cell) from scratch
Arthur Chow retweeted
🥇 & 🏆people's choice goes to Brendan Camellato from the lab @_Choi_Junhong
🥈 @MeganEKelley from the Sfeir lab
🥉 @arthurwchow from the lab @CalebLareau