PhD student at @BBS_Harvard Past: AAV engineering @DevermanLab @BroadInstitute, Mass spec @slavovLab @NUBioE1
Cambridge, MA
Joined November 2018
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Albert Chen retweeted
We have released a preprint “Targeting AAV vectors to the CNS via de novo engineered capsid-receptor interactions”.
We developed gene delivery vectors with known mechanisms of action & predictable tropisms by targeting AAVs to specific proteins.
tinyurl.com/2ndsuvp6
Albert Chen retweeted
1⃣Developing a method is just the first step. ✔️
2⃣Helping others adopt it is the second step 👇
Thanks to @aleks_petelski, @edemmott and the entire @slavovLab team for this @NatureProtocols article!
nature.com/articles/s41596-0…
Albert Chen retweeted
And its out! My/@Emmottlab first PI paper “Characterising proteolysis during SARS-CoV-2 identifies viral cleavage sites and cellular targets with therapeutic potential”.
nature.com/articles/s41467-0…
This was a huge collaborative effort with 19 authors spanning 4 continents!
My awesome sister just released her book!
Uplifted tells the personal stories of how 21 Asian American entrepreneurs built their businesses, overcame their greatest challenges, and drew strength from their identities to uplift others.
kickstarter.com/projects/upl…
Albert Chen retweeted
We've created an interactive website to visualize >100,000 experimental measurements of how mutations to #SARSCoV2 RBD affect binding by antibodies & sera: jbloomlab.github.io/SARS2_RB… Explore it to examine a wealth of information about the antigenic effects of viral mutations. (1/n)
Albert Chen retweeted
Version 2 of covidcg.org is up! New data selection interface, now able to handle all 733,480+ SARS2 genomes from GISAID.
Please send us your feedback and help us to debug the site!
Albert Chen retweeted
We’ve updated our SARS-CoV-2 preprint investigating proteolysis by viral and host enzymes during SARS-CoV-2 infection! Lots of new data, and an author list now covering 4 countries on 3 continents! Read it here: biorxiv.org/content/10.1101/…
Albert Chen retweeted
Our joint single-cell analysis of proteins & RNAs in differentiating macrophages appeared in @GenomeBiology genomebiology.biomedcentral.… (preprint: biorxiv.org/content/10.1101/…)
We analyzed ~ 3,000 proteins and RNAs across single monocytes and macrophages, and found ...
Albert Chen retweeted
New paper: Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2. genomebiology.biomedcentral.… now published in @GenomeBiology
Albert Chen retweeted
I’m delighted to share the first @emmottlab preprint! In this paper we study protease activity in #SARSCOV2 infected cells. We found multiple unknown cleavage sites in viral proteins, and novel cellular targets of the viral proteases essential for virus replication.
Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets for drug repurposing biorxiv.org/cgi/content/shor… #bioRxiv
Albert Chen retweeted
Our talk just got bumped earlier to 5 PM CDT / 6 PM EST. The closing talk for the @ASGCTherapy COVID-19 symposium. Grab your happy hour drink of choice and tune in for our 15-min talk! 🍻🍷🧋🍵🍼🧃🥤🍾🍸🥂🍹🧉🥛🧬 webcastregister.live/asgct_c…
Our team is presenting the last talk today 5:15-5:30 PM CDT @ASGCTherapy COVID-19 Symposium. Thank you again for selecting our abstract for a talk - very excited to share our new @CovidCg covidcg.org resource!😃
Albert Chen retweeted
Heads up on a 2-day all-star @ASGCTherapy COVID-19 symposium starting tomorrow. Dr Fauci is the opening keynote. @atchen_ @DevermanLab @shingheizhan our group is giving the last talk on Wednesday afternoon 5:15PM CDT! asgct.org/events/covid-sympo…
Really excited to share this tool that we've been working on over the past few months. The code is 100% open source at github.com/vector-engineerin…, if you would like to replicate our analyses, rebuild our app, or suggest any features that would help with your COVID-19 research.
Hello, twitterverse! This is the twitter account for the new COVID-19 CoV Genetics (covidcg.org/) browser created by Ben @DevermanLab Albert Chen @atchen_ Shing Zhan @shingheizhan Alina Chan @ayjchan and Kevin Altschuler.
Twitter's being weird... site is at covidcg.org
Albert Chen retweeted
Hello, twitterverse! This is the twitter account for the new COVID-19 CoV Genetics (covidcg.org/) browser created by Ben @DevermanLab Albert Chen @atchen_ Shing Zhan @shingheizhan Alina Chan @ayjchan and Kevin Altschuler.
Albert Chen retweeted
Our paper is out on @biorxivpreprint describing our SARS CoV2-human protein-protein interaction map and drug predictions from the data. It was a honor to work with so many fantastic scientists around the world. -Nevan biorxiv.org/content/10.1101/…
Albert Chen retweeted
The revised version of SCoPE2 biorxiv.org/content/10.1101/… has 3 major improvements:
1) SCoPE2 data for >1,000 single cells. No, the reviewers didn’t ask for it, but we thought it's a good way to characterize the reproducibility and throughput, much better than adjectives. 1/4
Albert Chen retweeted
A dream of single-cell proteomics bit.ly/sc_proteomics w/ C.Vogel @nyuniversity @slavovLab @Northeastern, R. Aebersold @eth @KharchenkoLab @harvardmed J. Cox @MPI_Biochem @Rune_Linding @Humboldt_Uni
Albert Chen retweeted
New research from Chen et al. "DART-ID increases single-cell proteome coverage" plos.io/2YGfFb5
Albert Chen retweeted
Science has a sustainability problem. 53eig.ht/2IJMVIL