Proyecto de I+D+i en líneas estratégicas. Mutaciones somáticas y hematopoyesis clonal como factores de riesgo en aterosclerosis: del laboratorio a la clínica.
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Joined May 2022
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@AtheroClonal is a public-private collaborative project funded by @CienciaGob I+D+I Líneas Estratégicas 2021. We aim to unveil the connection between somatic mutations, clonal hematopoiesis driven by these mutations and atherosclerotic cardiovascular disease. Meet the team 🧵
AtheroClonal retweeted
We are excited with our outstanding lineup of speakers, and welcoming you in Madrid for the #CNICConference #immuno_CVD in November!
Register here 👉 cnic-conference.com/ 🔥
@CNIC_CARDIO
@aramiro_ramiro
@SanchoLab
@PilarMartinFern
🔔 Save the date! On line registration for the #CNICConference ‘Understanding immunity in cardiovascular disease’ is open until October 10.
📅 The Conference will take place on November 13-15, 2024 at @CNIC_CARDIO Auditorium, Madrid.
Registration is free of charge 📌 cnic-conference.com/online-r…
#CNICConferences #Cardiovascularhealth #Immunity
AtheroClonal retweeted
Our latest paper -> On identifying the mutations driving clonal hematopoiesis using machine learning models - BoostDM-CH
Great team work by @SantiDemajo, @JoanEenric, @fmuinos et al
Tweetorial 👇
‼️ The final version of our article “Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis” is out in Cancer Discovery @CD_AACR: aacrjournals.org/cancerdisco…
Learn more about our findings in this thread 👇🏽
AtheroClonal retweeted
📢Investigadores del @CNIC_CARDIO descubren un nuevo factor de riesgo cardiovascular🫀: la hematopoyesis clonal.
➡️La colchicina es útil en las mutaciones del gen TET2.
➡️Los estudios se publican en @NatureMedicine y 'European Heart Journal'.
✍️@rocio79 dozz.es/a4ir92
AtheroClonal retweeted
Valentin Fuster Nuevo Factor de Riesgo Cardiovascular @ivanovich13 @SIAC_cardio @CardiologiaSVC @CNIC_CARDIO isanidad.com/291825/el-cnic-… @ivanovich
AtheroClonal retweeted
Exploring the chicken-or-egg dilemma between clonal hematopoiesis and atherosclerosis. Our latest study, published today in @NatureMedicine (nature.com/articles/s41591-0…), addresses this critical question. Check out the thread below ⬇️
AtheroClonal retweeted
🔬Un nuevo estudio publicado en @NatureMedicine y realizado por personal investigador del @CNIC_CARDIO y del @CIBER_CV, identifica el papel de la #hematopoyesisClonal en la #aterosclerosis. Para combartirlo, proponen el uso de la #colchicina
ciberisciii.es/noticias/desc…
AtheroClonal retweeted
A longitudinal study finds that whereas clonal hematopoiesis confers an increased risk of #atherosclerosis, the reverse is not the case, arguing for a unidirectional effect of clonal hematopoiesis on atherosclerosis
nature.com/articles/s41591-0…
AtheroClonal retweeted
Two new studies on mutated blood stem cells clones, appearing frequently in our blood with aging (known as CHIP)
—strong association with atherosclerosis nature.com/articles/s41591-0…
—benefit of colchicine, an anti-inflammatory agent, vs atherosclerosis in mice and heart attack in @UK_Biobank participants, with TET2 CHIP
academic.oup.com/eurheartj/a…
@josejfuster @NatureMedicine @ESC_Journals @CNIC_CARDIO
AtheroClonal retweeted
And another paper online simultaneously with #ESCCongress! With Dr. Valentin Fuster and colleagues @CNIC_CARDIO, we clarify the relationship between clonal hematopoiesis and atherosclerosis. @NatureMedicine nature.com/articles/s41591-0… More details ➡️ bit.ly/3Z8hi38
AtheroClonal retweeted
Now online simultaneously with #ESCCongress! Colchicine as a promising candidate to prevent atherosclerosis in TET2-mutant clonal hematopoiesis. A great collaboration with @pnatarajanmd led by @MariaAZuriaga and @ZhiYu_ACGT. bit.ly/3T6JYFW
Our study led by @MariaAZuriaga @ZhiYu_ACGT & with @josejfuster uses murine & human genetic studies to infer that individuals with TET2 clonal hematopoiesis may derive potent CV risk-reduction with colchicine academic.oup.com/eurheartj/a… @ESC_Journals
🟢Colchicine has been proposed to lower CV risk via NLRP3 inflammasome inhibition.
🟢TET2 clonal hematopoiesis has been proposed to raise CV risk via NLRP3 inflammasome activation.
👉The signal convergence validates both notions & provides a path for potentially using a low-cost available medicine for CV risk reduction in TET2 clonal hematopoiesis.
@buutrg @M_Mesbah_Uddin @NakaoTetsushi @abhinrl @mchonig #ESCCongress
AtheroClonal retweeted
Great talk on #clonalhematopoiesis and #CVDrisk just delivered by @josejfuster at the #GTH2024 in beautiful Vienna!
AtheroClonal retweeted
Particularly excited about research within the Atherosclerosis Program 😆: youtube.com/watch?v=xm9wBcRT…
AtheroClonal retweeted
Interested about ongoing research at @CNIC_CARDIO? Take a look! youtube.com/watch?v=4lJfMMDJ…
AtheroClonal retweeted
Interesado en la investigación que hacemos en @CNIC_CARDIO? ¡Echa un vistazo! youtube.com/watch?v=exJTGHkn…
AtheroClonal retweeted
Important new study in @JAMACardio linking clonal hematopoiesis to coronary artery disease in individuals with East Asian ancestry! doi.org/10.1001/jamacardio.2… Congrats to all authors @BennyCho8! Happy to write the accompanying editorial comment @CNIC_CARDIO : doi.org/10.1001/jamacardio.2…
AtheroClonal retweeted
@CNIC_CARDIO is offering a Postdoctoral researcher for the group Hematovascular Pathophysiology @josejfuster #cnic_empleo #SOMMaJobs More info: cnic.es/es/convocatoria/post…
AtheroClonal retweeted
An early Holiday present! @myoclonal researchers at @IRBBarcelona used machine learning to develop a data-driven approach to distinguish mutations that drive clonal hematopoiesis from non-drivers! Available as a preprint medrxiv.org/content/10.1101/…. Tweetorial 👇🏼
❗️Our preprint “Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis” is out medrxiv.org/content/10.1101/…
Thrilled to present this study by @SantiDemajo @JoanEenric @fmuinos @miggrau @MaAndrianova @abel_gonzalezp @nlbigas in a tweetorial 👇🏽
AtheroClonal retweeted
📢❤️10 #PhD positions @FundlaCaixa Incoming INPhINIT 2023 at @CNIC_CARDIO @SaludISCIII @BecariosFLC #laCaixaFoundFellows @SOMM_alliance
More info and research lines here and this thread:👇
cnic.es/en/noticias/10-phd-p…
AtheroClonal retweeted
Un honor poder presentar este proyecto sobre hematopoyesis clonal y aterosclerosis subclínica en el IV Congreso Interdisciplinar de Genética Humana en Málaga @blrneble @josejfuster @BenedettaIzzi @CNIC_BioIT @UdG_CNIC
#CongresoGenética23
AtheroClonal retweeted
I was about to share my opinion on the paper on clonal hematopoiesis by deCODE just out in @NatureGenet, but I wouldn’t do it better than @AlexBickMDPhD, so just check his thread ⬇️
Conceptually flawed paper from deCODE on #CH in @NatureGenet today
TLDR: Different clones have distinct disease profiles so lumping distinct forms of CH together is uninformative. #CHIP is associated with CVD in both smokers and non-smokers in full UKB 🧵nature.com/articles/s41588-0…
