my name Sage. 25 transfem, white, ATLien. she / her. I like mecha and some shonens. commie.
Atlanta GA
Joined February 2022
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transfem mecha pilot 🏳️⚧️ retweeted
IF THE MAN AHEAD OF YOU FALLS PICK UP HIS BALLOT AND KEEP VOTING
transfem mecha pilot 🏳️⚧️ retweeted
Remember to practice self-care tonight.
Drink as much caffeine and alcohol you can starting at 6 pm when polls first close. Since one is a stimulant and one is a depressant, they’ll combine harmoniously in your system, allowing you to remain alert yet calm as results pour in.
transfem mecha pilot 🏳️⚧️ retweeted
there's a japanese color book from the 1930s (sanzo wada's dictionary of color combinations) that designers are obsessed with. i've been turning the palettes into men's outfits. here are some of my favorite combos.
transfem mecha pilot 🏳️⚧️ retweeted
There has been no greater forces to strengthen left electoralism than the Vote Vote Vote song and this mussolini clip
transfem mecha pilot 🏳️⚧️ retweeted
In addition to massaging tight face fascia, a neck focused lymph drainage massage can reduce facial puffiness + improve cognitive function.
This was the first video I tried back when my health was terrible.
I still use it now.
Some people get more from these exercises than any diet or supplement gives them.
Pair the two together.
teapawt.net/GutOptimized/status/21…
transfem mecha pilot 🏳️⚧️ retweeted
KY-06 is the first toss-up House race to close on Election Night (6 PM ET). Here are my benchmarks for what it could signify nationally:
🟥>R+8: Pack it up
🟥R+5–8: Blue ripple
🟥R+0–4: A 2018-style repeat
🟦D+0–3: Blue tsunami like 2006
🟦>D+4: Reverse 2010 for Democrats
transfem mecha pilot 🏳️⚧️ retweeted
results coming in from the united states now and its looking promising
transfem mecha pilot 🏳️⚧️ retweeted
thread of fashion references used in steel ball run specifically cause it seems fun so lets go
versace
transfem mecha pilot 🏳️⚧️ retweeted
>be cell biology postdoc at UCLA, 1986
>job: purify vesicles from rat liver
>ez
>purify the vesicles
>something else in the tube
>weird little barrels, way bigger than a ribosome
>fkisdis
>purify the barrels instead
>mostly protein, tiny bit of RNA
>not related to vesicles at all
>new organelle just dropped?
>lab holds a naming contest
>"vaults" "sure, "great name" "
>write it up, publish
>conclusion section: "function: unknown"
>surely we'll figure it out in a couple years
>reviewers: "are you sure this isn't just a virus"
>prove it isn't a virus
>apply for grants to study it
>first question on every call: "what does it do"
>"we're working on it"
>be early 90s
>vaults hang around the nucleus
>"they must plug the nuclear pores"
>they do not
>be different scientist, Netherlands, 1995
>chasing LRP, mystery protein that shows up in chemo-resistant tumors
>clone it
>~88% identical to rat vault protein
>it was vaults the whole time
>whole cancer field piles on
>a decade of papers on vaults and drug resistance
>nobody ever proves vaults cause it
>back at UCLA
>one of the vault proteins binds telomerase
>"guys what if this is the fountain of youth"
>knock it out in mice
>telomeres fine, aging fine, mice fine
>2002
>knock out the main vault protein
>mice: perfectly healthy
>knock out all three vault proteins
>completely vaultless mice
>mice: basically fine, some subtle immune stuff
>mfw something in every cell since the dawn of eukaryotes does nothing obvious
>"just test it in yeast"
>yeast don't have vaults
>"worms then"
>no vaults
>"fruit flies"
>no vaults
>mfw every easy model organism dropped them
>try making recombinant vaults in insect cells
>expecting to get some loose protein at best
>get fully assembled vaults
>can't find a single free copy of the protein anywhere
>turns out ribosomes 3D-print the barrel straight off the mRNA
>lolwut
>still no function
>be structural biologists
>spend years modeling it as 96 proteins with 8-fold symmetry
>2009 X-ray structure
>it's 78 proteins, 39-fold
>caps still blurry
>2025: caps are closed, 13-fold, tiny hole in the middle
>still no function
>NIH funds vault research for 15 years
>NIH: "so what does it do"
>"...we're working on it"
>NIH stops returning calls
>if we can't figure out what it does, we'll make it do something
>stuff a cancer-fighting chemokine inside the barrel
>inject into mouse lung tumors
>immune cells swarm in, tumors shrink
>2011: "human trials within three years"
>2024: "human trials next year"
>2025 database: preclinical
>start a YouTube channel explaining vaults to anyone who'll listen
>be different scientist, Broad Institute
>want to record what genes a cell turned on over time
>try tethering mRNA to a bacterial protein
>doesn't work
>stumble onto a YouTube channel about some obscure barrel organelle
>engineer vaults to grab mRNA
>RNA half-life goes from ~17 hours to ~132 hours
>publish in Science, 2026
>use it to catch drug-resistance genes in lung cancer cells before the drug even hits
>the vault guy is thrilled
>still nobody knows what vaults are for
>be epigeneticists
>screen the whole genome for methylation set at random in the early embryo
>separately study kids conceived in different seasons in rural Gambia
>both screens independently point at the same gene
>it's the goddam vault RNA gene
>its methylation depends on conditions around conception, locked in for life
>linked to cancer outcomes, blood sugar, cleft palate
>mfw the mystery barrel has a mystery RNA that remembers when you were conceived
>40 years later
>one of the most abundant structures in your cells
>still not in a single textbook cell diagram
>we use it anyway because yolo
>function: unknown
>be CNRS scientist in montpellier
>dig through institut curie's chemical library looking for an HIV cure
>find a quinoline that blocks rev from exporting viral RNA
>somehow involved in splicing
>start a company called splicos based on this
>4 years later, company gets merged into abivax
>molecule is now ABX464
>run two phase 2a HIV trials
>it shrinks the viral reservoir a bit
>mfw "a bit" does not cure HIV
>but the bloodwork is weird
>random microRNA miR-124 is cranked tf up
>mfw miR-124 is a major chill pill for inflammation
>turns out the drug grabs the cap-binding complex and splices exactly one random lncRNA
>that lncRNA becomes miR-124
>why that one? lol idk
>HIV attacks GI tract, so maybe give it to colitic mice?
>guts heal lmao
>let's yolo this for ulcerative colitis
>2018 phase 2a works
>let's try with rheumatoid arthritis while we're at this
>2020 covid hits
>"what if it stops cytokine storms"
>yeah let's cure ARDS too lol
>french gov makes it a national research priority
>500 patients in
>2021 trial stopped, does nothing
>stock eats dirt
>ceo: "covid was hyper-acute, chronic inflammation is different, trust me"
>quietly drop rheumatoid arthritis
>go all in on UC
>phase 2b works
>2025 phase 3 induction hits
>stock goes vertical
>2026 maintenance trial: half get remission on drug vs 10 % on placebo
>placebo rate is the lowest ever seen in a trial like this
>NDA to FDA planned late 2026
>mfw a failed HIV drug, a failed covid drug, and a lucky lncRNA might become a blockbuster UC pill
>mfw it took 18 years
transfem mecha pilot 🏳️⚧️ retweeted
This the first time i ever seen a black character not get hoe’d by the plushie skin tone holy shit
transfem mecha pilot 🏳️⚧️ retweeted
do i have enough motion here to emphasize just how much i love PPPPPP, the shonen manga that was axed at an unprecedented 70+ chapters, with one of the most haunting endings i've read to date, and that everyone should experience it at least once in their lives?
transfem mecha pilot 🏳️⚧️ retweeted
The answer I arrived at in some recent research into the 3rd century is that what's missing from this discussion is that it is specifically the Eastern Mediterranean that got into gnosticism.
This is because the eastern Mediterranean of middle and late antiquity had a lot of material prosperity and safety but also a lot of inequality, stagnant social and economic mobility, and anxiety around status, whether the music was about to stop, plus ennui from migration and urbanization caused by the pax romana.
It is the single time and place in history which most resembles our own in terms of what adaptive and maladaptive pathologies were viable. Alexandria was something like mixing a favela with LA.
It's not the terror and brutality of nature that makes people gnostic, or else it would have been the German tribes who thought it up. Gnosticism is fundamentally a disease of failing to thrive in artificial conditions that feel hostile to human nature. Flinching under the hand of a slave master is what gives you the idea of an evil demiurge, not watching lions kill antelope or whatever
