@berke_lab

​We investigate neural mechanisms of  motivation, learning, choice and action, and how these are altered in neurological & psychiatric disorders.

 UCSF
berkelab.org
Joined May 2018
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The latest installment of the lab's story on DA dynamics is now published in Life. Work from @mohebial and Val Collins, in which we demonstrate how cholinergic interneurons in accumbens promote DA release and enable motivated approach elifesciences.org/articles/8…

Accumbens cholinergic interneurons dynamically promote dopamine release and enable motivation

In awake behaving rats, cholinergic interneurons in the nucleus accumbens drive dopamine release via nicotinic receptors, boosting motivation to work.

elifesciences.org
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Stop by our posters on Tuesday afternoon and talk (dopamine) to @FaustTW @BonmiG @LeahVinson15 @mohebial @TimAmosK @didiaam @ MarianaDuhne
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Checkout the latest preprint from the lab
Ali Mohebi@mohebial7 Nov 2022
Folks- I have a preprint update on our #dopamine quest: "Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens". I will try to summarize it here: biorxiv.org/content/10.1101/… 1/9

Cholinergic Interneurons Drive Motivation by Promoting Dopamine Release in the Nucleus Accumbens

Motivation to work for potential rewards is critically dependent on dopamine (DA) in the nucleus accumbens (NAc). DA release from NAc axons can be controlled by at least two distinct mechanisms: 1)...

biorxiv.org
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A Spectrum of Time Horizons for Dopamine Signals
Ali Mohebi@mohebial3 May 2022
Here's an updated version of our latest thoughts on dopamine. More data, more analyses, more words, same spirit. Will you check it out and let me know what you think? biorxiv.org/content/10.1101/…

A Spectrum of Time Horizons for Dopamine Signals

Dopamine input to striatum can encode reward prediction error, a critical signal for updating predictions of future rewards. However, it is unclear how this mechanism handles the need to make...

biorxiv.org
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Latest preprint from our lab: Altered basal ganglia output during self-restraint biorxiv.org/content/10.1101/…

Altered basal ganglia output during self-restraint

Suppressing actions is essential for flexible behavior. Multiple neural circuits involved in behavioral inhibition converge upon a key basal ganglia output nucleus, the substantia nigra pars reticu...

biorxiv.org
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Amin and I are delighted to host Josh @berke_lab this Thursday at 4:30pm to have a fun discussion about my favourite molecule, dopamine, and the role it plays in multi-scale learning (in carbon! which may inspire learning in Silicon?). Join us if you're around n bring ur friends!
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Our new preprint is now available on biorxiv: "Striatal dopamine pulses follow a temporal discounting spectrum"
Ali Mohebi@mohebial3 Nov 2021
Here's a new dopamine idea we have been cooking for a while now. I think it's palatable now: Striatal dopamine pulses follow a temporal discounting spectrum. I will try to explain a few chirps, but to get the full story read our preprint. 1/n biorxiv.org/content/10.1101/…

Striatal dopamine pulses follow a temporal discounting spectrum

The striatum is critical for making decisions based on predictions of future reward. These predictions can be updated by brief pulses of dopamine, encoding reward prediction errors. However, it is...

biorxiv.org
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We have a position open for a staff research associate. Join our team! sjobs.brassring.com/TGnewUI/…
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Join us tomorrow for the UCSF PARC international conference on pain and addiction. 8am-1:30pm PST painaddiction.ucsf.edu/event…
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Hot off the presses, #carbonfiber arrays for #electrophysiology or #dopamine sensing through #FSCV. Devices can also be precisely localized within the tissue. Massive team effort by @berke_lab @women_neurosci @DawenCai. doi.org/10.1088/1741-2552/ab…
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Hey old friends. We haven't talked for a while. ViDA is now back for an exciting one-day event in November. We are delighted to present and showcase the work of future leaders of the dopamine field. If you are an advanced postdoc with a full-length story to tell, please apply!
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As part of a new multiyear effort to increase the diversity of our faculty the Physiology Department and Neuroscience Program at UCSF are advertising for a new tenure track faculty member at any rank - aprecruit.ucsf.edu/JPF03083
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All materials are available at @Addgene and the @neurophotonics viral core!
Nature Methods@naturemethods8 Sep 2020
Check out the newly developed red and yellow dopamine sensors from the @LinTianLab. nature.com/articles/s41592-0… rdcu.be/b6VSo
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Stop! There is a RdLight ahead. Of course, dLight is amazing, but RdLight is doubly fun. I am so happy that we got to collaborate on the characterization of this amazing tool with @tpatriarchi @LinTianLab and co... nature.com/articles/s41592-0…
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- Next-gen Cellular-scale (5x10um) silicon probes for high-density (256ch) neurophysiology with ultra-high-density packing (as little as 66µm between shanks) - Slice-in-place approach for precise registration of recording sites. biorxiv.org/content/10.1101/…
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Josh Berke (UCSF) @berke_lab Dopamine firing versus dopamine release during motivated behavior. ​Moderator: Howard Fields (UCSF) @HowardNeuro Co-Moderator: Lauren Burgeno (University of Oxford) @LBurg 05-21-2020 youtube.com/watch?v=ZMp10-xK…

Josh Berke - Dopamine firing versus dopamine release during motivated...

Josh BerkeUCSF05-21-2020Dopamine firing versus dopamine release ...

youtube.com
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Here is our list of confirmed speakers so far. Submit an abstract by May 8th to present your own research! You can also register just to participate as an attendee without presenting. We are also seeking volunteers to help moderate and keep things running smoothly!
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Preprint of a study spearheaded by Bon-Mi Gu. Here we investigated the population dynamics of rat GPe neurons during preparation-to-stop, stopping, and going. Check the full-text if you're interested! biorxiv.org/content/10.1101/…

Globus pallidus dynamics reveal covert strategies for behavioral inhibition

Flexible behavior requires restraint or cancellation of actions that are no longer appropriate. This behavioral inhibition critically relies on frontal cortex - basal ganglia circuits. A central node...

biorxiv.org
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Happy holidays from us to you!
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Dopamine release drives motivation, independently from dopamine cell firing #nppjournal #hottopic from @berke_lab nature.com/articles/s41386-0… #authortweet #dopamine #motivation
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