This is how you ignore negative thoughts btw

Conspiracy theorists: the NSA has manipulated the standard setting process so HTTPS appears to be impenetrable, but they have a backdoor because of advanced mathematics beyond your imagination The real world, so much dumber than they could ever imagine: the secret key is 4

I wear a stethoscope so that in a medical emergency I can teach people a valuable lesson about assumptions.

Surround yourself with people who see a flying car and say, "Awesome!" Not people who see a flying car and say, "It's not actually flying" or "I don't see the point." This post is not about cars :)

More than 1 million private-sector jobs have been created since Inauguration Day, while the federal workforce has shrunk by 328,000, bringing it to its lowest level since the 1960s.

Surprise 1: Anthropic acquired a one-person biotech . . . Surprise 2: that person is me Surprise 3: I’m here to tell you all about it Yes, this is what you think it is; after 6 yrs of increasingly loose anonymity: the Professor Oak reveal post …and yes, it has gotten so boring around here that I’m literally doxxing myself to spice up the timeline ------- Ok, allow me to introduce myself. My name is Cody Tranbarger. I mostly tweet, but occasionally find time to dabble in drug dev & starting/building biotechs. My past lives span the VC, crossover, startup continuum; Prof Oak has been my way of keeping a digital foot in those worlds, despite having my physical feet planted elsewhere. The past 18 mo, ‘elsewhere’ was Mithril Medicine, a co. I founded to develop bsAbs for LAMA2-CMD & other ECM-related genetic diseases. Mithril was born out of hands-on building with @MikeNGladstone, @JasonPaulRhodes, @LifeSciVC, & team @atlasventure. Somehow, I made enough half-decent calls along the way (even a broken clock is right twice a day, eh?) to convince them Mithril/I warranted a small seed. While I can hardly rationalize such an outrageously cavalier bet, I’m grateful for it, & I'd partner with Atlas again in a heartbeat. In typical AV fashion, Mithril’s primordial form was virtual, decentralized, & ultra-lean. This stage tends to be short-lived, but for Mithril, it worked surprisingly well, for surprisingly long, thanks in part to the rapid maturation of the AI tools I used liberally. Eventually, Mithril became a bit of an experiment itself - to find the upper bound of how far it could scale as a single operator + a bunch of Claude (+ a stellar bench of part-time consultants). In parallel, I started spending time with @nc_frey, @an1lam, & @CoefficientBio team; and promptly experienced, for the 1st time, AI at the frontier. Soon thereafter, Mithril stopped looking like an experiment, & started looking like a preview of an entirely new operating model. From that spark came “Pipeline-in-a-Person.” The idea immediately resonated when we shared it here back in April; and it was central to the shared vision that led to Anthropic’s acquisition of Mithril, & my joining the team. Why join Anthropic? Three reasons. (1) For Mithril, the programs continue, with more resources & infrastructure behind them, and as much Claude as I can put to work. (2) For me, the chance to start several more programs, & find out how many one person can actually run in parallel - an almost unprecedented luxury for a curious drug hunter. (3) For our mission, a path to institutionalize & scale this new way of working, then put it in the hands of all of biopharma, all over the world - which, candidly, I find the most energizing. Will AI x Bio cure diseases? Unequivocally yes, imo… but not by the route that gets the most airtime. Rather than timeline acceleration & compression, I see orchestration & parallelization as today's low-hanging fruit. Most drug hunters see a handful of go/no-go calls in a career, & spend entirely too much of the rest trading emails (my inbox can attest). Give them the bandwidth to run several programs at once, and the time to focus on scientific judgment, and I’m willing to bet they’ll make better calls. And at scale, better calls translate to more drugs, higher hit rates, broader patient impact, & likely, a disease or 10 or 100 cured. I couldn't be more excited to build toward that future @AnthropicAI. Finally, a heartfelt thank you to BioTwitter/X. The end of anonymity is bittersweet, but if anyone’s earned a proper introduction, you all have. It’s difficult to overstate how much this app has done for me: a decade of education, plenty of friends, many job opportunities, several mentors, a few investors, even a co-founder (fmr). It was the generosity of this community that inspired me to start posting 6 years ago, after just as many years lurking. I hope I’ve been able to pay it forward, in my own small way. But, to be clear, Prof Oak isn’t going anywhere. Same beat, same themes, and now, a front-row seat to drug development at the frontier. Stay tuned for dispatches from the trenches; and remember... Gotta Cure 'Em All

Never seen Star Wars. None of them. Never will. “Omg you’re missing out” Maybe. You’re missing out on being a multi-millionaire. Keep your movie.

A warning from 1964. A fight that continues today. 📜 In “A Time for Choosing,” Ronald Reagan warned about expanding government power and the erosion of Americans’ constitutional freedoms. On the speech’s 62nd anniversary, those constitutional safeguards remain central to NCLA’s work defending Americans from unlawful government power. Follow the fight.

BREAKING: The leader of the democratic opposition in Venezuela María Corina Machado has just returned to the country from exile. ¡Hasta el final! 🇻🇪🇻🇪🇻🇪

THE FUTURE IS HERE

I very much atheistically agree with this. I can understand a place for the horror genre in film and literature. To me, Mary Shelley's "Frankenstein" and Blatty's "The Exorcist" are worthwhile and reasonable metaphysical plays with compelling moral implications. The late 20th century made a cheap mockery of all that, to audiences of rotten taste and ethical vacuity. What producers, directors, and writers offer now is essentially the threadbare titillation of childhood ghost stories, amped with modern cinematic process (students of Pragmatism will note that last word). The audience for that is morally decrepit, even before the show starts: it's why they're attracted to it.

oh my fucking god

#SocialMediaVideoCritique This is a nice re-enactment of "talking baby scenes," popularized in films like BABY GENIUSES and LOOK WHO'S TALKING. - The set design is large-scale to de-emphasize the size of the adult actresses here. - The chairs are very bulky, such that the actresses seem almost swallowed by the furniture, like children. - The wardrobe on the actresses is amorphic and a few sizes too large for them, giving the audience an increaased "small child" or "infant" impression. - The make-up is simple and the lighting is broad, resulting in a smoothing effect on their faces, much like that of a baby. - The final "baby" element is dialogue that ends to repeat, and at times have a circular motion. This is an interesting way of see-sawing the audience between the baby babble that the adults hear in these films, and the cohesive words heard by the babies alone. - The "Easter egg" here is the placement of baby bottles with "UNWELL" printed on the side. It's a nice subliminal touch by the director to impress on the viewer that the babies have some kind of sickness. Fin.