Illuminating virus dynamics @CSSBHamburg through @MHH_life and @RESIST_cluster. A little zoo at home. Equal responsibility dad of three. Views own

CSSB Hamburg
Joined June 2020
Try ASD-STE100 to make Opus 5 in Claude science to cut the cr*p! The best way I found so far to make Opus 5 understandable
We'll be spending a lot more time trying to understand the outputs of language models. A few thoughts, tips & tricks: Writing. Something I've had success with: Ask your LLM to explain something in ASD-STE100, it's a controlled language specification originally developed for aerospace maintenance documentation. LLMs well-versed in this language and it comes with heavy constraints on clean writing style that I often find a lot more readable. Sometimes I've tried to soften it a bit e.g. ask for "80% of the way to ASD-STE100" because the spec is quite stringent. But even better: Diagrams / images. Instead of writing, ask your LLM to create a diagram. These can be a lot easier to process, parse, and understand. But even better: Web pages. Ask for output "in HTML" to get a beautiful, interactive webpage. LLMs are getting really good at frontend and can create beautiful experiences, animations, etc. But even better: Explainer videos. The output format I am most bullish on is fully custom / bespoke explainer videos generated on any arbitrary topic. Experiment with things like "Create a 3b1b style video explainer on X. Use my ElevenLabs API key for audio narration". (you'd need an API key for the latter or you can ask your LLM to find you decent free alternatives that use your local compute). This is actually starting to work! In summary: - As LLMs get better, they will do more and more of the legwork autonomously, and a lot more of our work will rise up the abstractions into oversight and understanding. - Luckily, LLMs can help here too because as intelligence and code are increasingly abundant, you can ask for large, custom, discardable software artifacts (e.g. web apps, video explainers) that would have never made sense to create before. Push the boundaries here and you'll be surprised.
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Fables safeguards are hilarious. Asking about the contents and historical context of a 100+ years old postcard must be a cybersecurity or biosafety issue… 🤣
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Me to Fable on an empty repo: "Let's come up with a fun project that does not get stopped by safety guards." Fable: "Fable 5's safety measures flagged this message." 🤣
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On June 8 at 19:00, CSSB will be hosting a panel discussion entitled “Coding Life: Leben gestalten mit biologischen Werkzeugen.” Registration: cssb-hamburg.de/codinglife
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ChatGPT Images 2.0 is happy to help you fake westerns for a publication ready figure 😂😂😂
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Jens Bosse retweeted
Very excited to share the first announcement of our international VISION symposium on integrated structural virology! Looking forward to see many of you in Hamburg!
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🚀 The largest-ever open‑source protein‑complex treasure trove - 1.7 million of AI‑predicted complexes now live in the AlphaFold Database In collaboration with @emblebi, @GoogleDeepMind, and @SeoulNatlUni, we have added millions of predicted complexes to the AlphaFold Database to accelerate global health research. 🧵👇
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AlphaFold predicts millions of protein complexes, but how many are real? We built LUCIA, a rapid cell-free assay that answers this in <3 days. Applied to HSV-1, we: ✅ Discovered dozens of novel interactions ✅ Provided the first experimental benchmark for ipTM scores ✅ Went from prediction → interface mutation → functional proof Explore 23,215 models across 3 herpesviruses: herpesfolds.org/herpesppis 🔗 Preprint at: doi.org/10.64898/2026.04.02.…
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Become my colleague at CSSB! Hannover Medical School is recruiting a W1 Professor in Systems Virology (m/f/d), based at CSSB Hamburg. Focus: system-wide analysis of virus–virus & virus–host interaction networks. tinyurl.com/msh2449a #Virology #SystemsVirology #AcademicJobs
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W1=assistant professor
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Do you want to image RNA in living cells? Check out our new live-cell Click labeling approach. An amazing collaboration with the Meier Lab at UHH and the Wagenknecht Lab at KIT! doi.org/10.1002/anie.2025166… Congratulations, especially to Doerte, Eileen, and Iven! Thanks to DFG CRC1648
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Jens Bosse retweeted
ExM STED for #fluorescencefriday: Herpes virus particles 4-5x expanded and imaged with confocal and 3D STED. Staining: viral glycoprotein (🟨STAR RED) and tegument protein (🟦STAR 580). Don’t just expand your sample, expand your options with abberior dyes and STED – the perfect match for expansion microscopy! Sample courtesy: Jannik Jensen & @bosse_lab @CssbHamburg & Hannover Medical School, Institute of Virology, Germany #ExM #3DSTED #herpesvirus #virology
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If you’re interested in our latest developments have a look at: Comparative Systems Virology Symposium: Jens Bosse youtu.be/PlAcAR1-IJA?si=G3TO… via @YouTube Thanks to the @czbiohub for organizing and my amazing team for the great data!
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👣 Accurate cell tracking remains one of the hardest problems in #bioimaging. Meet Ultrack, a fast, reliable platform that performs especially well on whole-embryo tracking, new in @NatureMethods. Led by @loicaroyer & @jobragantini. Learn more: czbiohub.org/life-science/dy…
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A big thanks to Carolina Arias, Amy Kistler and Noam Stern-Ginossar for organizing an amazing meeting on comparative systems Virology yesterday @czbiohub in San Francisco! czbiohub.org/events/frontier…
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