Brandon Logeman (@brandon_logeman) header
Brandon Logeman (@brandon_logeman) profile picture

Brandon Logeman

@brandon_logeman

BRAIN Initiative K99/R00 Awardee || Studying hormonal control of neuronal circuits at the single cell level || 🐷 former pig farmer 🐷 #FirstGenCollege

 Harvard University
Joined April 2010
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Photo by Brandon Logeman (@brandon_logeman)Photo by Brandon Logeman (@brandon_logeman)Photo by Brandon Logeman (@brandon_logeman)Photo by Brandon Logeman (@brandon_logeman)Photo by Brandon Logeman (@brandon_logeman)
Brandon Logeman retweeted
Rahul Satija (@satijalab) profile picture
Rahul Satija@satijalabFeb 17
Excited to share VIPerturb-seq! New tech from my lab which aims to improve the cost, data quality, and efficiency of single-cell CRISPR screens so that they are accessible to any lab - even at genome-wide scale Preprint and 🧵 (1/): biorxiv.org/content/10.64898…
Genome-wide single-cell perturbation screens with VIPerturb-seq

Genome-wide single-cell perturbation screens with VIPerturb-seq

CRISPR-based screening combined with single-cell sequencing (i.e. Perturb-seq) enables systematic mapping of genetic perturbations to molecular phenotypes. While Perturb-seq is well-suited to profile...

biorxiv.org
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Brandon Logeman retweeted
Vega Shah (@dr_alphalyrae) profile picture
Vega Shah
@dr_alphalyrae23 Nov 2025
The latest issue of COB describes how AI infrastructure can create value for biotechnology beyond finding new drug candidates. Highly recommend reading if you work at the intersection of tech and life sciences
Image from Vega Shah (@dr_alphalyrae)
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Naive population genetics question: in multi-ancestry GWAS, are ancestry-specific associations common? For example, the recent BD analysis from @PGCgenetics found EAS specific associations. Rule or exception? @SashaGusevPosts @dgmacarthur @tuuliel nature.com/articles/s41586-0…

Genomics yields biological and phenotypic insights into bipolar disorder

Nature - Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

nature.com
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@sanogenetics @doctorveera would love to hear any thoughts you have on this. Your podcasts and blogs have been a great source of information.
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A new paper has identified an answer to this question, in which a structural variant causes the de novo creation of a cardiomyocyte-specific enhancer, leading to ectopic expression of a potassium channel and heart disease.
Brandon Logeman (@brandon_logeman) profile pictureBrandon Logeman@brandon_logeman13 May 2024
I’m looking for examples where a gene is normally expressed in cell type A but a GWAS/QTL hit contains a variant that causes ectopic expression in cell type B. All examples welcome, plz RT! @jkpritch @doctorveera @SashaGusevPosts @dgmacarthur @tuuliel @anshulkundaje
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Excellent write up by @doctorveera found here:gwasstories.com/p/de-novo-en…
De novo enhancer creation by a noncoding mutation

De novo enhancer creation by a noncoding mutation

Genetic investigation of a cardiac arrhythmia reveals a new noncoding Mendelian disease mechanism

gwasstories.com
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A big congratulations to our #GWAS24 Poster Winners, Luis Eichelmann (@LuisEichelmann) from @UniLuebeck & Brandon Logeman (@brandon_logeman) from @Harvard 🎉👏
Image from Fusion Conferences (@Fusion_Conf)
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New GWAS study examines when a baby takes their first steps 🧬 ➡️ 🚼 ➡️ 🚶‍♀️ SNP based heritability, a lower bound of heritability calculated using only common variants, shows up at ~25%, much higher than I would have guessed. Work led by @annagui86
PGC Consortium (@PGCgenetics) profile picturePGC Consortium@PGCgenetics16 May 2024
This recent GWAS preprint is the first to explore genetic influences on the age at onset of walking 🚶‍♀️🚶, a milestone that may indicate broader (neuro)developmental delays. Find out more⤵️ medrxiv.org/content/10.1101/…
Genome-wide association meta-analysis of age at onset of walking

Genome-wide association meta-analysis of age at onset of walking

Onset of walking is a developmental milestone with wide individual differences and high heritability in humans. In this genome-wide association study meta-analysis of age at onset of walking (N=70,...

medrxiv.org
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Targeting 💊 to specific cell types in the brain is challenging, but this new paper uses a bifunctional molecule that delivers an NMDA receptor antagonist to GLP-1 receptor expressing neurons in an effort to treat obesity 🧵
Image from Brandon Logeman (@brandon_logeman)
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Finally, the clever use of a disulfide linker enables the two molecules to dissociate upon entry into the reducing environment of the cytoplasm. This strategy could further be used to deliver non-cell permeable reagents to cell types of interest.
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If you've made it this far thanks for reading and here again is the link to the original paper. nature.com/articles/s41586-0…
GLP-1-directed NMDA receptor antagonism for obesity treatment

GLP-1-directed NMDA receptor antagonism for obesity treatment

Nature - Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.

nature.com
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I’m looking for examples where a gene is normally expressed in cell type A but a GWAS/QTL hit contains a variant that causes ectopic expression in cell type B. All examples welcome, plz RT! @jkpritch @doctorveera @SashaGusevPosts @dgmacarthur @tuuliel @anshulkundaje
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In a G0 cell, if Cohesin is continuously chugging along performing loop extrusion it must be going through a large amount of ATP. Does anyone have an idea how much of the cellular energy budget is dedicated to this process? @job_dekker @Jesse_R_Dixon @Anders_S_Hansen
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