@briansmithlab

Laboratory of Brian C. Smith, Dept of Biochemistry, Medical College of Wisconsin @medicalcollege @mcwgradschool Opinions my own.

 Milwaukee, WI
briansmithlab.info
Joined May 2013
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  • Following138
  • Followers148
6Media
Breaking News: A Feast of Genomics in 3D lead by Dr. Brian Smith, Co-Director, Structural Genomics Unit @MCW_Research @UDNconnect @RareDiseases @MCWPediatrics @MCWCancerCenter @Dr_R_Kurzrock
MCW Mellowes Center@mellowescenter2 Apr 2024
🔍✨Dive into our latest findings! Our @jbiolchem study showcases how pinpointing the distinct effects of #PBRM1 BD4 missense variants on #protein #structure & function is key.🧬🔬#Genomics #ProteinStructure #Research shorturl.at/gxAD3
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The Program in Chemical Biology is hiring a bachelor's or master's level chemist to join our highly collaborative team: careers.peopleclick.com/care…
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#Smithmigas #womeninscience #WomenInSTEM #InternationalWomensDay
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We're excited for our PBRM1 bromodomain inhibitor work to be featured in @PracticalFrag! A nice example of our @mcwchembio fragment screening pipeline. Thanks to @EmilyDykhuizen for cell work. @MedicalCollege @MCW_Research
Practical_Fragments@PracticalFrag13 Feb 2023
Fragment screening by NMR and optimization produces selective inhibitor for neglected bromodomain family VIII protein PBRM1 practicalfragments.blogspot.… @briansmithlab @nmr900 @MCW_Research @ACSPublications @JMedChem
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New Smith Lab from @MedicalCollege of WI publication in @ACSBioMed Journal of Medicinal Chemistry: "Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening" doi.org/10.1021/acs.jmedchem… #bromodomains #NMR #PBRM1 #SAR

Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening

Abstract. PBRM1 is a subunit of the PBAF chromatin remodeling complex that uniquely contains six bromodomains. PBRM1 can operate as a tumor suppressor or t

pubs.acs.org
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The Program in Chemical Biology at the Medical College of Wisconsin has opened a search for tenure-track positions. Review of applications will start October 14. For more details visit our posting in C&E News:chemistryjobs.acs.org/job/37…

POSITION Opportunity Opening in LOCATION - ACS Chemistry Careers

A new

chemistryjobs.acs.org
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Hot off the press from the Smith Lab at @MedicalCollege of WI! "N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic ß-cells" tinyurl.com/2p9amwxh #bromodomains #p65 #BRD4 #diabetes
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New publication from @Sprague_Dan of the Smith Lab - Trisubstituted Triazenes : the First Ligands of the sY12-Binding Pocket on Chemokine CXCL12 in @ACSMedChemLett pubs.acs.org/doi/full/10.102…

Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12

Abstract. CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in i

pubs.acs.org
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Felice was the recipient of our 10,000th COVID-19 vaccine administered by medical student Natalie Yass. Learn more about the COVID-19 vaccines here: covid19.mcw.edu #ThisIsOurShot
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Wearing a mask helps reduce the spread of COVID-19 when used in conjunction with other preventative measures, including physical distancing, frequent hand washing and cleaning high traffic surfaces. #WearAMask
Froedtert
@Froedtert19 Oct 2020
Protect yourself and the ones you love. Please wear a mask.
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Cheers to the #TwoWomen scientists who won the #NobelPrize in chemistry today! Congrats @doudna_lab and Dr. Charpentier!
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Signal boost nejm.org/doi/full/10.1056/NE…
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New Smith Lab publication in Bio-Organic Chemistry - Novel activity-based probes targeting #sirt1, inspired by Cravatt lab #HDAC probes. Inaugural 1st-author paper for @mcwgradschool student @cjgoetz; teamwork by @Sprague_Dan. authors.elsevier.com/a/1biMO…
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Why has no one thought of opening a bar near a hospital and calling it PubMed
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Excited to share that Dr. Robert Golden, Dean of @uwsmph and I crafted an op-ed in the Milwaukee Journal Sentinel on the @AAMCtoday road map to reset the nation's approach to the COVID-19 pandemic. This important message should be shared far and wide! jsonline.com/story/news/solu…

Opinion: There is a safe, healthy path forward from the ravages of the coronavirus

A road map developed by the Association of American Medical Colleges would reset the nation's approach to the coronavirus pandemic.

jsonline.com
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Congratulations to our newest #NIH T32 postdoctoral trainees, Ryan Adam, PhD, Joshua Nord, PhD, and Michael Flinn, PhD @ivorbenjamin2 facebook.com/Cardiovascular.…
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Brian Smith Lab retweeted
Allison Ebert@AllisonEbertPhD2 Jun 2020
This is not a new idea, but it bears repeating. "All lives matter" is a worthless phrase until black lives are also included in the "all". #BlackLivesMatter
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“The new study does not ask why, but earlier research, including an analysis published last year by the NIH, has found that black applicants are more likely to propose studying health disparities, which are less likely to be funded by the agency.” chronicle.com/article/Black-…

Black Scientists Face a Big Disadvantage in Winning NIH Grants, Study Finds

White scientists outscore African-Americans in a key hurdle of NIH grants. The new research comes at a time when the nation’s racial inequities are under intense focus.

chronicle.com
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MYTH: Warm weather and heat can kill COVID-19. With all the information available about #coronavirus (COVID-19), it's important to separate fact from fiction. For trusted information and resources, visit the MCW Coronavirus Resource Center at: covid19.mcw.edu #MCWCOVID19
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Congratulations to our newest Smith Lab PhD graduate! @mcwgradschool student Kelsey Kalous successfully defended her thesis. We are so proud of her!
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