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Caleb Dawson

@calebadawson

Exploring microscopic life @WEHI_research 🔬🇦🇺 Breast immunology | #SciArt | Jesus ✝️=❤️️ | @AulieTsee

 Melbourne, Victoria
calebadawson.com
Joined April 2012
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Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)Photo by Caleb Dawson (@calebadawson)
We filmed platelet production to see how each person makes 100 BILLION of them a day. Platelets are tiny blood cells that prevent bleeding. They're made by giant cells in the bone marrow called megakaryocytes, but exactly how has been controversial… doi.org/10.1084/jem.20191206

Membrane budding is a major mechanism of in vivo platelet biogenesis

Platelets are made by megakaryocytes but the mechanism is unclear. We filmed the direct release of platelets by membrane budding and show that this is a major mechanism of platelet production.

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I’m excited to share our latest study, published today in @NatImmunol It has been long known that pregnancy reduces the risk of developing breast cancer, yet the biological mechanisms underlying this protection have remained largely unknown. nature.com/articles/s41590-0…
Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer

Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer

Nature Immunology - Here the authors identify an abundance of a tissue-resident memory-like T cell population in the breasts of women who have given birth. These cells can contribute to tumor...

nature.com
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Follow me on Bluesky for (increasingly rare) microscopy and immunology content! bsky.app/profile/scicad.bsky… I miss having endless time for sharing creation in all its microscopic glory, but early parenthood is even better (most of the time). #microscopy #sciart #immunology
Image from Caleb Dawson (@calebadawson)
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What's the craziest Cre/loxP strategy you've seen? I was sick of manually sketching out complex Cre/lox and Dre/rox recombination outcomes, so I created a little program to simulate them. Hope it saves you some time. cadaws.github.io/recombine/ #molecularbiology #cloning #genetics
Image from Caleb Dawson (@calebadawson)
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Using advanced #imaging & AI, WEHI scientists uncovered how hormone-sensing breast cells divide, grow & move during puberty and pregnancy. This helps us understand how #breastcancer forms, especially in BRCA 1 & 2 carriers. @cellreports: cell.com/cell-reports/fullte…
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Discover your immune system with our expert researchers at WEHI, Parkville on April 29th 10 am! Hear about visualising immunity, engineered immune cells, T cells and breast immunology. dayofimmunology.org.au #WEHIresearch @WEHI_research @calebadawson #DayOfImmunology
Image from Day of Immunology (@DayofImmunology)
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Get to know your immune system at one of our FREE upcoming events! The Day of Immunology is fast approaching and to celebrate we have events running in Melbourne, Sydney, Perth, Brisbane, and Auckland. See the great opportunities and register at dayofimmunology.org.au
Image from Day of Immunology (@DayofImmunology)
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Breast cancer researcher @calebadawson was looking for something else when he stumbled on these fat cells lit up like glowing blue orbs. See more fascinating #ArtOfScience images: wehi.edu.au/artofscience #ScienceWeek
Image from WEHI (Walter and Eliza Hall Institute) (@WEHI_research)
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Adult zebrafish intestines, pancreas, and liver - lectin staining (magenta) #Science #Microscopy #Sciart #Zebrafish
Image from Julien Rességuier 🇪🇺 🇫🇷 🇳🇴 (@iceflon)
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Brilliant talk from @AmandaOPhD on spatial transcriptomics to uncover an IgA plasma cell niche in the lung. doi.org/10.1038/s41588-022-0…
Image from Caleb Dawson (@calebadawson)
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Impressive 3D Merfish from @Maurice_Y_Lee at the WEHI spatial transcriptomics symposium. Thanks for making the trip over to Aus!
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New in @sciencemagazine we report a role of taurine deficiency as a driver of aging. science.org/doi/10.1126/scie… youtu.be/dTdJQopKosw I thank all the collaborators and funders as well as my present and past institutions in USA, UK and India for supporting my team.
Taurine deficiency as a driver of aging

Taurine deficiency as a driver of aging

Taurine supplementation extends healthy lifespan in worms, rodents, and non-human primates.

science.org
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Thanks for having me @ajithvasanthan and @ONJCRI ! Thoroughly enjoyed the many chats and questions.
Ajith Vasanthakumar (@ajithvasanthan) profile pictureAjith Vasanthakumar@ajithvasanthan8 Jun 2023
Great to have @calebadawson @WEHI_research speak at our @ONJCRI institute seminar on all things macrophages in the mammary gland. Fantastic science and loved the stunning images!!
Image from Ajith Vasanthakumar (@ajithvasanthan)
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Thank you @drchristonkin for stepping in for me 🤩 and presenting my talk so well at the very last min 👏 after my emergency wisdom tooth surgery! 😬🤐 – at Lorne, Victoria
Image from Aurelie Dawson (@AulieTsee)
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Beautiful talk by @aulietsee on #toxoplasma and #latticelightsheet at #ACMM27 Now time to enjoy the amazing Perth weather!
Image from Caleb Dawson (@calebadawson)
Image from Caleb Dawson (@calebadawson)
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🥈2nd Place: Magalie BENARD, PRIMACEN, University of Rouen Image of a cellular interconnection between two human tumor cells whose cytoskeleton has been labeled with anti-tubulin, anti-vimentin antibodies and with Phalloidin probe. Imaged with confocal microscopy.
Image from France-BioImaging Research Infrastructure (@Fr_BioImaging)
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🥉3rd Place: Frédéric FERCOQ, PPL, Museum National d'Histoire Naturelle Stage 25 cuttlefish embryo (Sepia officinalis) observed under a confocal microscope. The cuttlefish was cleared and the tissue autofluorescence was captured.
Image from France-BioImaging Research Infrastructure (@Fr_BioImaging)
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Congratulations to Dr @AulieTsee
Image from Petrovski Lab (@PetrovskiLab)
Image from Petrovski Lab (@PetrovskiLab)
Image from Petrovski Lab (@PetrovskiLab)
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Cell biology postage stamps - new from USPS! about.usps.com/newsroom/nati… ht @StearnsLab
Image from Richard Sever (@cshperspectives)
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Excited to share our work showing STAT3 inhibition is a novel vulnerability for splicing factor mutant HSPCs in @CellReports cell.com/cell-reports/fullte… Congrats to 1st authors @postdocpotts Rosannah Cameron Great collab with @LabObeng @Amitvermamds @aditishasMD and so many others
Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibi...

Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibi...

Potts et al. show that STAT3 inhibition is a conserved vulnerability for splicing factor heterozygous mutant hematopoietic cells due to its impact on splicing. These findings suggest that STAT3...

cell.com
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Just wide-field epifluorescence
Image from Kaverina Lab (@KaverinaLab)
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