@cchlanger

Scientist @IMBA_Vienna interested in bringing computer science, software development, and agile project management best practices into life sciences.

Joined November 2020
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For those bioinformaticians who drown in genomic datasets and are asked to turn them into a paper, we present HiCognition: a visual exploration and hypothesis testing tool for 3D genomics. 🪄hicognition.com #3DGenome #bioinfo #ComputationalBiology #genomics #BioVis
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Proud bioinformatician @cchlanger presenting our new visualisation tool @hicognition at today’s @IMPvienna / @IMBA_Vienna PhD & PostDoc day 🧬
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The tool has some cool ideas around *genomic region sets* which aim to allow "users to address biological questions about how a specific type of region is composed, regulated, and organized in 3D space."
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Delighted to finally share our work on BacPROTACs, published today @CellCellPress! We bring the PROTAC approach to the bacterial world, hijacking ClpCP proteolytic complexes to induce targeted protein degradation. Read the full article here👇 authors.elsevier.com/sd/arti…
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cchlanger retweeted
IJCAIconf@IJCAIconf21 May 2022
🐦Early bird gets the worm 🪱 IJCAI-ECAI 2022 EARLY BIRD REGISTRATION closes on 30 May. 👉 Application for Student Volunteers closes on 23 May and the decision will be communicated before the early bird deadline. ijcai-22.org/register/ #IJCAI2022 #Vienna #Austria #KI #AI
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Our new preprint about @HiCognition: a visual exploration and hypothesis testing tool for 3D genomics is out: biorxiv.org/content/10.1101/…. Congratulations to @cchlanger and @michi8591 for developing this fantastic software. #3DGenome #biology #bioinfo #genomics #DNA #chromatin

HiCognition: a visual exploration and hypothesis testing tool for 3D genomics

The 3D organization of the genome and epigenetic marks play important roles in gene expression, DNA repair, and chromosome segregation. Understanding how structure and composition of the chromatin...

biorxiv.org
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HiCognition allows data analysis of genomic datasets based on the genomic region-set approach. Combined with efficient preprocessing and interactive data visualization, this enables rapid exploration. @hicognition #3DGenome #bioinfo #ComputationalBiology #genomics #scicomm 1/5
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Explore average behavior using aggregation widgets 🧬 HiCognition allows visualization of genomic features' average behavior at genomic regions, allowing users to explore both 1D- and 2D-genomic features. 4/5
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Discover associations using the LOLA widget 🧬HiCognition users can use a powerful widget that implements the LOLA algorithm to explore associations between genomic region sets and to discover regulatory, functional, or spatial patterns that are characteristic to them. 5/5
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In contrast to conventional genome browsers, which visualize a specific subregion, HiCognition can interactively analyze large sets of genomic regions that are of particular interest in many biological questions. @hicognition hicognition.com #3DGenome #bioinfo #DNA
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