Postdoc @IvanAhelLab @Dunn_School. Enamored by #PTMs,and the world of #ubiquitin and #ADP-ribosylation
Joined April 2012
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The first paper from my PhD is out @ScienceAdvances! It's a tale of two #PTMs brought together by Deltex E3. Deltex surprisingly binds #NAD and modifies #ubiquitin tail with #ADPribose. This inactivates Ub, but is readily reversed by deubiquitinases. (1/3) advances.sciencemag.org/cont…
chatrin retweeted
Congratulations to the Poster Award winners #EMBOubiquitin24: Jason Collins from @werner_achim Kai Gallant from @MalteGersch and Chatrin Chatrin from @IvanAhelLab
Well done! 👏💫🏆 @YKulathu @polosimona1 @LabJoazeiro
chatrin retweeted
It has been an honour to host @UniofOxford's @chatrin_ch on her Scotland 🏴 tour's 1st stop in Dundee. We had many activities and reunited @CRUK_SI alumni @IPuoti and Helge. Very exciting work on #ubiquitin ADP-ribose from her PhD & postdoc work. Nice late night walk on the sea cliffs with @KevinHaubrich1
chatrin retweeted
We uncovered how UBE2K extends K48-linked #ubiquitin in @nchembio with our @CRUK_BI team (@gazsib), @UoGBioPhys (@maxgabro), and @BrianOSmith1967 using integrated structural biology 🧲#NMR & 💎 #Xray: rdcu.be/cEV5f #openaccess
chatrin retweeted
1/13 COVID-19 had a significant impact on our research activity but our researchers adapted brilliantly and work @CRUK_BI continued to thrive. This #WorldCancerDay #WCD2021 , we're highlighting just some of the successes from the past year:
Creative approach to switch CAR T cells on/off! Achieved through CRBN-degron interaction induced by lenalidomide. Cool system.
Researchers have created new variants of anticancer CAR T cells that can be quickly switched on and off with a clinically approved drug, allowing precise control over the cells’ activities. Read more in @ScienceTM: ($) fcld.ly/baz9bcq
chatrin retweeted
Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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‘The game has changed.’ AI triumphs at solving protein structures sciencemag.org/news/2020/11/…
Thanks to @maxgabro @Mark_A_Nakasone @ferojahmed @gazsib @DSumpton @BrianOSmith1967, twitterless Lori and Danny for their contributions. I am also grateful to @CRUK_BI for sponsoring and hosting my PhD, it's a great place to do science. @UofGMVLS (3/3)
chatrin retweeted
Literature adds to reality, it does not simply describe it. ...it irrigates the deserts that our lives have already become. #CSLewis
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"Education is the most powerful weapon which you can use to change the world." - Nelson #Mandela #educationfirst
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"You are never too old to set another goal or dream a new dream" #CSLewis #NoteToSelf -- C. S. Lewis
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Globally, around 40% of adults aged 25 and over had raised #blood pressure in 2008, interactive graph: goo.gl/qug2E #CutRisks
chatrin retweeted
Abt 30% of #cancer deaths are due to the 5 leading behavioral & dietary risks: high body mass index, low fruit & vegetable intake... (1/2)
