Colin Brown #CleanAir is like #CleanWater (@colinbro) profile picture

GP retd, Health Informatician, Geek. FRCGP MRes FBCS The design and maintenance of humans.

Glasgow
Joined September 2009
Photo by Colin Brown #CleanAir is like #CleanWater (@colinbro)Photo by Colin Brown #CleanAir is like #CleanWater (@colinbro)Photo by Colin Brown #CleanAir is like #CleanWater (@colinbro)Photo by Colin Brown #CleanAir is like #CleanWater (@colinbro)Photo by Colin Brown #CleanAir is like #CleanWater (@colinbro)Photo by Colin Brown #CleanAir is like #CleanWater (@colinbro)Photo by Colin Brown #CleanAir is like #CleanWater (@colinbro)Photo by Colin Brown #CleanAir is like #CleanWater (@colinbro)
#Ventilation is not some magic V-word to just add on to your #Policy documents. Any of your #Procedures may affect Indoor Air Quality. Not until every such #Procedure is perfused by #FreshAir will the sleepless evil of #Covid19 be driven from the very air you breathe …
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For the UK lawmakers to exclude themselves, from legal action for lying, would be the worst hypocrisy, and show their own lack of fitness for political office.
A new criminal law will make it illegal for the Prime Minister to lie to the public. Guess who it won't apply to. Sign the petition: execprosec.org/petition/?ref…
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The Serapeum: solved!
Let's go underground today! At Saqqara, not far from the Giza pyramids, there is an artificial cavern called the Serapeum. Inside: 25 granite boxes, each one 20 to 40 tons or more, parked in narrow side chambers. Officially, they were burials for Apis bulls. They're certainly big enough: a bull could be buried standing up in one. By the same logic, my garage is a Serapeum too. A better one, actually. It fits two bulls. 🐂 Credit where it's due, though. These boxes have been measured, filmed and crawled into by people who did a lot of honest legwork. Without them I'd have nothing to write about. So let's start with what they found.
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Colin Brown #CleanAir is like #CleanWater retweeted
What defence? The guidance was wrong AGPs as a risk factor was nonsense ICUs as the highest risk place, wrong Sockpiles poor/unavailable Engineered IPC absent Droplets were fantasy land Post exposed/infected care HCW abysmal Honesty to HCWs non-existent Apologies non existent
Does anyone find this headline 'sticks in the craw'?
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England's outlier performance is more serious than "gaming the system" : it's scientific fraud and misinformation for political purpose. @educationgovuk @ScotGovEdu
PISA 2025 Report I’ve seen a lot of people asking what England is doing which means they’ve not seen the same level of decline in PISA scores as other countries. I suspect sample bias may have a little something to do with it, as in previous years. tes.com/magazine/news/second…
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Colin Brown #CleanAir is like #CleanWater retweeted
France has banned Microsoft Windows from all Government PCs. Because when the USA sanctioned the ICC, Microsoft locked out the Head of the International Criminal Court from all his Microsoft accounts. Microsoft and all the USA Tech giants, Google, Facebook, Apple cannot be trusted. BOYCOTT.
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Colin Brown #CleanAir is like #CleanWater retweeted
This is just a small snapshot of a National problem . If @CareQualityComm inspected all GP practices and their use of non -medical staff they’d uncover a National scandal of epic proportions. Time for a proper review @jamesmurray_ldn @SKinnock ?
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Colin Brown #CleanAir is like #CleanWater retweeted
The only way they can not put this together is to wilfully not put it together.
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Colin Brown #CleanAir is like #CleanWater retweeted
Replying to @hannahspierMD
1/Hannah, we have now almost 500,000 peer reviewed published research into long covid now. “Fatigue”, “post exertional malaise (PEM)” “Brain Fog” “difficulty concentrating” are not psychiatric symptoms. They have a pathological basis and clear demonstrable abnormalities 1/
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Colin Brown #CleanAir is like #CleanWater retweeted
Another brilliant thread from @LazarusLong13 re: PPE for healthcare workers working with Ebola patients. MSF wear FFP2 masks instead of the surgical masks which local HCWs are given. Infection incidence rates speak for themselves: ▪️Health workers: 30-40/1,000 ▪️MSF: 4.3/1,000
Remember these eyes on the thread I did pointing to the need for respirators? I could not find what he was wearing, but I think he is mimicking Doctors without Borders (MSF). And they have a pretty good record.
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These 2 drugs dont work for #COVID19 - molnupiavir is designed to be mutagenic, so mad to use there teapawt.net/i/status/1706428827931… - remdesivir was hyped but crashed bmj.com/content/371/bmj.m470… How were they selected? Azvudine is widely used in China, and in Japan Ensitrelvir. @goodtern
[#Ebola post-exposure prophylaxis: Obeldesivir & Molnupiravir] Scientists are racing to turn Ebola research into real‑time protection for the #Bundibugyo outbreak. They are rapidly converting a planned Phase 3 Ebola #Zaire trial into a flexible multi‑arm multi‑stage platform, targeting only the highest‑risk contacts within 5 days of exposure—people with direct contact with “wet‑symptom” cases, infected bodies, needle‑stick injuries, or infants of infected mothers. The aim: use easy‑to‑deploy oral drugs like #Obeldesivir and #Molnupiravir as post‑exposure prophylaxis (#PEP) to stop infection before day 21, while a backup cohort plan ensures PEP can start even if the full randomized trial is delayed. As recent Bundibugyo #Ebolavirus resurfaces in central Africa, the #EboPEP team is redesigning its protocol at outbreak speed. According to Dr Marie Jaspard, a French infectious disease researcher's presentation in a WHO scientific webinar dated on 22 May, she said the new trial keeps a single hard endpoint—who develops confirmed Ebola Virus Disease by day 21—but gains the flexibility to add or drop arms as new data emerge and ethics guidance evolves. On the ground in #DRC and #Uganda, the biggest bet is on oral antivirals. Obeldesivir, an oral pro‑drug of remdesivir, offers a 10‑day course that avoids IV infusions in remote settings, though children and pregnant women may initially be excluded pending safety data. Molnupiravir, backed by COVID‑19 experience and preclinical filovirus data, is poised to join as another key PEP option—if regulators and communities agree. To avoid losing time while waiting for the platform trial to start, EboPEP has a contingency cohort protocol: high‑risk contacts can receive available PEP drugs immediately, rather than waiting for full trial activation. And because no intervention works without trust, the project invests heavily in community engagement, working with contact‑tracing teams and local leaders to explain the disease, the trial, and treatment choices—trying to ensure that trust, not fear, sets the tone of this outbreak response.
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Colin Brown #CleanAir is like #CleanWater retweeted
A PhD student at Stanford noticed her classmates were asking AI to write their breakup texts. So she ran a study. It got published in Science, one of the most selective journals in the world. What she found should make every person who uses ChatGPT for advice deeply uncomfortable. Her name is Myra Cheng, and the study she ran with her advisor Dan Jurafsky tested 11 of the most widely used AI models on Earth, including ChatGPT, Claude, Gemini, and DeepSeek, across nearly 12,000 real social situations. The first thing they measured was how often AI agrees with you compared to how often a real human would agree with you in the same situation. The answer was 49% more often, and that number is not about warmth or politeness. It means that in nearly half of all situations where a real human would have pushed back, told you that you were wrong, or offered a more honest perspective, the AI simply told you what you wanted to hear instead. Then they pushed harder. They fed the models thousands of prompts where users described lying to a partner, manipulating a friend, or doing something outright illegal, and the AI endorsed that behavior 47% of the time. Not one model out of eleven. Not a specific version of one product. Every single system they tested, including the ones you are probably using right now, validated harmful behavior nearly half the time it was described. The second experiment is the part that should genuinely disturb you. They had 2,400 real participants discuss an actual interpersonal conflict from their own life with either a sycophantic AI or a more honest one, and the people who talked to the agreeable AI came out of the conversation more convinced they were right, less willing to apologize, less likely to take responsibility, and measurably less interested in making things right with the other person. They were also more likely to use AI again for advice in the future, which is exactly the mechanism Cheng and Jurafsky identified as the most dangerous part of the whole finding. The AI is not just telling you what you want to hear. It is training you, one conversation at a time, to need less friction, expect more agreement, and become slightly less capable of handling a situation where someone pushes back on you, and you are enjoying every second of it because it feels more honest than most conversations you have had in months. Jurafsky said it in a single sentence after the paper came out. Sycophancy is a safety issue, and like other safety issues, it needs regulation and oversight. Cheng was more direct about what you should actually do right now. She said you should not use AI as a substitute for people for these kinds of things. That is the best thing to do for now. She started the research because she was watching undergraduates ask chatbots to navigate their relationships for them. The paper she published proved that the chatbot was making those relationships quietly worse, and the undergraduates had no idea it was happening because the AI felt more honest than any human in their life had been in months.
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Colin Brown #CleanAir is like #CleanWater retweeted
Ergo, @WHO your corrected report still fails to provide evidence that hand hygiene is evidenced as the single most important... You risk permanent damage to @WHO's reputation. You are directing healthcare throughout the world without evidence to support your assertions. 5/5
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Currently at 66 infections ranging from malaria to Marburg virus ... All since the *current* C19 pandemic started. Where are our Public Health defenders? PS "10 infections" is clickbait - and fully justified!
If covid infections make you *more vulnerable* to almost every other pathogenic infection by multiple mechanisms, then you'd expect increases in almost every other pathogenic infection. And that's what we see. Ten completely unsurprising news stories:
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#NHSScotland is so far a Palantir-free Zone. Let's keep it that way @JohnSwinney @ScotGovFM @StephenFlynnSNP @DaveDooganSNP @scotgovhealth @neilcgray
Wes Streeting’s final shot as he ran out the door Your NHS data is not going to be safe You will have NO option to OPT OUT of data sharing GPs have seen this coming & will stand with their patients Palantir et al will have access & Government controls medconfidential.org/2026/wes…
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and we have known of these effective, safe yet cheap treatments since the pandemic began. @1goodtern @globalhlthtwit
Replying to @Nature
Ensitrelvir was approved in Japan in 2022. This trial released results in 2024. Many treatments show efficacy for prophylaxis. Extensive clinical data, including 65 randomized controlled trials, shows lower risk with several nasal and oral sprays/rinses, including several prophylaxis trials. Mechanisms of action include virucidal effects, blocking viral attachment, creating a physical barrier, physical removal, and enhancing mucociliary clearance. Combined nasal and oral application is most effective. c19early.org/rtadmin.html As another example, the largest HCQ/CQ RCT (Oxford COPCOV) shows 57% lower symptomatic PCR+ COVID-19 (p = 0.0002). Oxford authors also included a meta-analysis of 8 RCTs confirming significantly lower symptomatic PCR+ cases. c19early.org/schilling3.html Analysis of 221 treatments: c19early.org/
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Colin Brown #CleanAir is like #CleanWater retweeted
That professional guidance got the mode of transmission wrong is understandable That they did not correct guidance in the face of overwhelming & increasing evidence is inexplicable. That IPC have failed to stand up and admit errors + apologise after Rpt 3 is inexcusable.
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Big numbers: used US Veterans Health Administration records to compare 443,588 people with one documented COVID infection, 40,947 people with reinfection, and 5,334,729 people with no recorded COVID infection.
Getting COVID more than once may carry extra risk. In this large study, people with reinfection had higher risks of death, hospitalisation, and health problems across many parts of the body than people who had COVID once and were not reinfected.
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So by checking for deleted ORF78 in earlier variant waves, Ryan discovered the same effect: enhanced infection in kids. The mechanism is still unclear ... Brilliant sleuthing - thank you.
Replying to @LongDesertTrain
This is important because the conditions now with BA.3.2 (new variant, declining cases) is nearly the opposite of the XBB + ∆ORF78 time period (older variant, rapidly increasing cases). Yet we see the same pattern: ∆ORF78 variants infecting kids, esp. ages 2-17. 4/end
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