@cornu_copiae

Neuroscientist | Professor of Medical Psychology @uni_bonn | Neuroscience of Motivation, Action, & Desire Lab @neuroMADLAB 🧠 ⚡ @nbkroemer.bsky.social

 Bonn & Tübingen, GER
neuromadlab.com
Joined August 2014
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402Media
Out now @NatureComms: We knew that interoceptive signals guide motivation, but it was not known if we can boost motivation by emulating vagal signals. Here, we show that non-invasive stimulation increases invigoration. W/ @eudaimonja @glassybrain nature.com/articles/s41467-0…

Vagus nerve stimulation boosts the drive to work for rewards

Nature Communications - The vagus nerve transmits signals between the gut and the brain thereby tuning motivated behavior to physiological needs. Here, the authors show that acute non-invasive...

nature.com
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❄️Explore our first 2026 issue! ❄️ nature.com/natmentalhealth/v… Cover design: @Marina_C_Spence
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Your stomach called – your striatum picked up! But does this actually happen in humans? Using simultaneous dopamine PET/fMRI, we show that the gut hormone #ghrelin helps the brain adjust motivation to current metabolic need. Here’s what we found👇 biorxiv.org/content/10.64898…
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Do you get hangry because glucose levels drop or is it due to hunger? We collected EMA+CGM over four weeks and found that mood swings are best explained by conscious ratings of metabolic states. A lower interoceptive sensitivity was associated with higher mood variability.
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This work was led by @KristinKaduk @neuroMADLAB and you can find the preprint here: biorxiv.org/content/10.1101/…

Glucose levels are associated with mood, but the association is mediated by ratings of metabolic...

Hunger is commonly linked to negative mood and mood shifts are thought to arise from sensing the body’s internal state. However, it is unclear whether circulating glucose levels affect mood subcons...

biorxiv.org
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Happy to see that people are interested in our work.
Brandon Luu, MD
@BrandonLuuMD6 Feb 2025
🧠 Depression is linked to rewired food cravings. People with depression crave carbs more and find less reward in fats & proteins. Could the gut-brain axis explain this? 🧵1/14
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Outstanding & fact-rich article by @jenapincott in @sciam about the #vagus nerve, #depression, #inflammation and the important progress in the field of bioelectronic medicine. Fresh hope for millions who should benefit from VNS in the near future. scientificamerican.com/artic….

How the vagus nerve could influence physical and mental health

The healing potential of the brain’s most interconnected nerve intrigues researchers

scientificamerican.com
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The first paper from the lab! In collaboration with @HyungJinChoi_ , we derived the need and motivation component from homeostatic RL, and showed that AgRP neurons and lateral hypothalamus LepR neurons encode need and motivation, respectively. science.org/doi/10.1126/scia…

A normative framework dissociates need and motivation in hypothalamic neurons

Experimental and computational methods elucidate the neural substrates of need and motivation in hypothalamic neurons.

science.org
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Ever questioned whether fMRI might not reveal the whole picture about human cognition? Check out our new paper in which we address this issue using novel simultaneous fMRI/fPET. academic.oup.com/cercor/adva… @SharnaJamadar @emmaxliang @misicbata @gary_egan

Metabolic and functional connectivity provide unique and complementary insights into cognition-co...

Abstract. A major challenge in current cognitive neuroscience is how functional brain connectivity gives rise to human cognition. Functional magnetic reson

academic.oup.com
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New paper in Imaging Neuroscience by J Hall, D Shahnazian, and R Krebs: Exploring distinct and joint contributions of the locus coeruleus and the substantia nigra/ventral tegmental area complex to reward and valence processing using high-resolution fMRI doi.org/10.1162/imag_a_00336
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Viewpoint discusses clinical trial results of GLP-1 receptor agonists for treating the weight gain and cardiovascular disease risk of psychiatric medications. ja.ma/4hzfSFF
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Body and brain must communicate to adapt behavior efficiently. Using the fly, we discover a bidirectional pathway between the fat body and the brain and show that fat body-produced dopamine changes food preference.
bioRxiv Neuroscience@biorxiv_neursci4 Nov 2024
A Bidirectional Brain-Fat Body Axis for Pathogen Avoidance biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Atlas of gray matter volume differences across psychiatric conditions biologicalpsychiatryjournal.…

Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a...

Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV...

biologicalpsychiatryjournal.com
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WTools: a MATLAB-based toolbox for time-frequency analysis biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking Inhibiting D1-neurons at −5 sec or D2-neurons at −2.5 sec, but not at other timepoints, reduced sucrose-motivated lever-pressing nature.com/articles/s41467-0…

Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking

Nature Communications - Volitional reward taking emerges through a sequence of preluding events. Yet, the underlying neural mechanism is not fully understood. Here authors show a series of temporal...

nature.com
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🔥Happy to share our latest work just published in Science Advances! Our team explored the dopaminergic system and its role in brain function by combining fMRI with [18F]FDG-fPET and optogenetic stimulations. science.org/doi/10.1126/scia…

Functional PET/MRI reveals active inhibition of neuronal activity during optogenetic activation of...

Optogenetic functional PET sheds light on molecular mechanisms of fMRI neuronal activity.

science.org
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🚨New pub out now! 🚨In this study we showed that performance level moderated learners’ sensitivity to reward-prediction errors. For some insights into what this might mean for instructors interested in motor skill acquisition, grab a free copy here 👇 doi.org/10.3389/fnbeh.2024.1…

Frontiers | Reinforcement learning in motor skill acquisition: using the reward positivity to...

According to reinforcement learning, humans adjust their behavior based on the difference between actual and anticipated outcomes (i.e., prediction error) wi...

frontiersin.org
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I am super excited to share this pre-print on the neurocomputational and neuroendocrine mechanisms of affect-based impulsivity!! If you're interested in how affective states alters decision-making via RL systems, take a look! 🙃 osf.io/preprints/psyarxiv/jv…
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Pavlovian impatience: The anticipation of immediate rewards increases approach behaviour link.springer.com/article/10…

Pavlovian impatience: The anticipation of immediate rewards increases approach behaviour

Cognitive, Affective, & Behavioral Neuroscience - People often exhibit intertemporal impatience by choosing immediate small over delayed larger rewards, which has been implicated across...

link.springer.com
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Only a few days remain to apply for our open PhD position(s). Join @neuroMADLAB in developing and investigating innovative treatments for motivational dysfunctions (B2 level German required for this position). karriereamukb.de/jobs/doktor…
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New online! Bitter taste receptors as sensors of gut luminal contents go.nature.com/3UsKPkV
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