Interested in DNA damage, mutations and evolution.
Munich, Germany
Joined March 2013
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Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/167996/…
You'll learn a lot and it'll be fun and interesting!
#DKTK @DKFZ @LMU_Muenchen
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Such a rad paper, congratulations!!
So pleased to have the paper out, available here: nature.com/articles/s41586-0…
For me this was discovery science as I had always hoped it would be. Unpredictable, a lot of fun, and some proper detective work with plenty of twists & turns on the way. Brief thread below 🧵
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Craig Anderson retweeted
🌟NEW PREPRINT ALERT!🌟
We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”
biorxiv.org/content/10.1101/…
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Craig Anderson retweeted
What is the most common type of mutations, causing cancer and genetic diseases? C to T mutations in CpGs: Signature 1.
What is the best understood mutational signature? Signature 1. Or is it?
Results of over 8 years of our work is finally out! 🧵1/
nature.com/articles/s41588-0…
Craig Anderson retweeted
📢We are moving to @Yale University! - very grateful to everyone @Cambridge_Uni and @YaleMed who is helping with our multifaceted move…
Want to be part of @aitken_lab 2.0? We are hiring at all levels - so get in touch!
It is official: My lab and I are moving to @YaleCancer Center in December! Very excited to be joining the Center of Molecular and Cellular Oncology and @YalePathology
Want to be part of @aitken_lab 2.0? We are hiring at all levels - so get in touch!
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Craig Anderson retweeted
'Defining precancer: a grand challenge for the cancer community'
nature.com/articles/s41568-0…
Craig Anderson retweeted
I'm excited to share that our team at @inocras has posted our whole-genome analysis of 1,364 breast cancer cases—the largest cohort with clinical records to date. Many thanks to our collaborators at Samsung Medical Center and Seoul St. Mary's Hospital. doi.org/10.21203/rs.3.rs-509…
Craig Anderson retweeted
Immune surveillance of cancers is thought to be an important force shaping tumour evolution.
Is the same true of somatic evolution in general? Does the adaptive immune system “see” non-self clonal expansions and eliminate them?
A:👇 by Babrara Walkowiak
biorxiv.org/content/10.1101/…
Craig Anderson retweeted
Fast and Accurate Estimation of Selection Coefficients and Allele Histories from Ancient and Modern DNA buff.ly/4gksMXr #science #evolution #biology #genome
Craig Anderson retweeted
We are thrilled to announce two open rank faculty searches @UofUGenetics: a broad search for all areas of genetics research (utah.peopleadmin.com/posting…)
& one focused on computational genomics faculty (utah.peopleadmin.com/posting…).
This launches a multi-year recruiting initiative!
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Craig Anderson retweeted
I am happy to share our new preprint led by two briliant junior researchers, Long Wang @LoongWANG3 and Christo Morison, on a gene-for-gene model in cancer immune coevolution. biorxiv.org/content/10.1101/…
Craig Anderson retweeted
Estimation of demography and mutation rates from one million haploid genomes biorxiv.org/cgi/content/shor… #biorxiv_genomic
Craig Anderson retweeted
FOUR modified RNA bases read out in one command with the latest Dorado release. Enabling so much greater exploration of RNA biology! #NanoporeConf
Dorado v0.8.0 #ncm24 release!
- v5.0 DNA transformer model performance improved for A100/H100 via kernel fusing, quantisation and leveraging i8 tensor cores.
- v5.1 RNA models with updated mod calling for m6A, pseU, and brand new calling of Inosine and m5C.
- Improved dorado correct performance, stability and flexibility.
- Introduces per-barcode configuration for poly(A) estimation with interrupted tails.
#nanoporeconf
github.com/nanoporetech/dora…
Craig Anderson retweeted
It's even more braided than you think, @maureenmkearney et al! Genomic studies show many species remain distinct in spite of abundant introgression. "Tangled banks, braided rivers, and complex hierarchies: beyond microevolution and macroevolution" doi.org/10.1093/jeb/voae065
Craig Anderson retweeted
Excited to share my first paper from grad school is out today! Mutations can affect the short-term fitness of an organism, as well as the rates and benefits of future mutations. We asked: how do these pressures balance in microbial populations? nature.com/articles/s41559-0…
Applications close tomorrow for a seriously good looking postdoc with Duncan Odom at DKFZ. jobs.dkfz.de/en/jobs/166889/…
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Craig Anderson retweeted
My department at Oxford is hiring - Assistant/Associate professor level positions at @LudwigCancer @NDMOxford. Broad interests in cancer cell plasticity, epigenetics, epitranscriptomics, microenvironment but all areas considered. Check out ad here: nature.com/naturecareers/job…
Craig Anderson retweeted
Our latest paper -> On identifying the mutations driving clonal hematopoiesis using machine learning models - BoostDM-CH
Great team work by @SantiDemajo, @JoanEenric, @fmuinos et al
Tweetorial 👇
‼️ The final version of our article “Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis” is out in Cancer Discovery @CD_AACR: aacrjournals.org/cancerdisco…
Learn more about our findings in this thread 👇🏽
Craig Anderson retweeted
Excited to share our lab's latest research, out today @NatureSMB, which describes how 53BP1 controls DNA Repair in class-switching B cells & BRCA1 mutant cancers. Final article can be found here:
nature.com/articles/s41594-0…; & the following thread walks you through the details
Our lab's latest is now out on BioRxiv. In this work we set out to understand how 'shieldin' regulates #DNArepair, focusing on its physiological function in B cells & pathological contributions to BRCA1-mutant cancers. Some background & take-home msgs (1/) biorxiv.org/content/10.1101/…
Excellent work Takahashi et al.
Embryonic genome instability upon DNA replication timing program emergence
nature.com/articles/s41586-0…
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