doing some science | using cryo-ET to study tissues in situ ❄️🔬 | @OxCellStruBio @RosFrankInst
Joined October 2019
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it was great to share some results from mine & @glynnca93's latest preprint! It has been an interesting meeting with plenty of overlap between different imaging modalities/sample prep disciplines. Lots of insightful discussion/ideas!🔬
@VolumeEM1
Jake Smith (@crying_EM), PhD student at the Franklin and @UniofOxford , gave a fascinating talk this afternoon about his PhD work studying the hippocampus using cryo-EM as part of the vEM Technology Forum's Cryo FIB-SEM Methods Development Session. #vEMTechForum2024 @VolumeEM1
After thousands of microscope hours and several years of painstaking optimisation, @glynnca93 and I are very excited to share our latest manuscript. We outline our approach to investigate the molecular organisation within hippocampus tissue using cryo-ET.
We hope that our structural and cell biology friends can adapt our approach to their favourite tissue biology question.
To find out more, please check out our preprint: biorxiv.org/content/10.1101/…
#teamtomo #LiftLaughLove
Jake Smith retweeted
Subtomogram averaging from lamellae
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Jake Smith retweeted
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!
biorxiv.org/cgi/content/shor…
big well done @hels_watson & team!
obligatory group meeting slide to commemorate such an occasion
hopefully you free up the GPUs now this is out
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excited to finally have a copy!
@BriegelAriane @FriedrichForst1
(also thanks Magdalen xxx)
