@danielleobarber

Immunologist at the NIH/NIAID/Intramural Research Program.

 Maryland, USA
niaid.nih.gov/research/daniel-l-barber-phd
Joined February 2012
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  • Following431
  • Followers696
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Daniel Barber, PhD retweeted
Mihalis Lionakis@LionakisLabAug 31
We previously showed that APS-1/APECED features excess IFNg responses that can be targeted therapeutically (Oikonomou NEJM 2024). We now extend this to show that early JAK inhibition can intercept the development of irreversible autoimmune endocrinopathies nature.com/articles/s41467-0…

Ruxolitinib prevents irreversible autoimmune endocrinopathies in APECED

Nature Communications - APECED is a monogenic autoimmune disorder resulting from deleterious variants in the Autoimmune Regulator gene. Here, the authors report the cases of two patients with...

nature.com
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Daniel Barber, PhD retweeted
Mihalis Lionakis@LionakisLabMay 7
In @elife: Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency doi.org/10.7554/eLife.111039…
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So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB
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We still don’t understand how T cells control tuberculosis. Our new paper shows that Mtb-specific T cells in NHP and human lung granulomas make many interesting effector molecules upon TCR stimulation. There’s a whole lot more to T cells in TB than IFNγ! cell.com/iscience/fulltext/S…
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We are looking to hire post-docs to work on T cell responses to M. tuberculosis infection using murine and NHP models. If you know T cells and wanna work on the top infectious killer check us out. The NIH intramural program is an amazing place!
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We are looking for post-docs! If you are interested in T cell responses to M. tuberculosis infection check us out. The NIH Intramural program is a great place to train!
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Daniel Barber, PhD retweeted
joanne flynn@joanneflynn1929 Aug 2024
Happy to share authors.elsevier.com/sd/arti… @CellPress Immunity. CD4 T cells contribute to protection against #TB in a reinfection macaque model by interacting with CD8s to generate an anti-inflammatory granuloma environment. Kudos to first authors Sharie Ganchua and @joshuabromley21
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Scientists at @NIAIDNews examined the roles of the prototypic pro- and anti-🌡️ #inflammatory cytokines IFNγ and IL-10 using the rhesus macaque model of mild #COVID19. 👇 Check out their discovery on the role of IFNγ in lung lesions. @PLOSPathogens | bit.ly/4f177To
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We are looking for a technician to join our team working on immune responses to tuberculosis in NHP models. The NIH is a super fun place to do research. Have a look! guidehouse.wd1.myworkdayjobs…
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Incredible study from @LionakisLab !!!
Mihalis Lionakis@LionakisLab30 May 2024
1/n Proud to share our latest work @NEJM. A long journey of integrated basic research and clinical care revealed a central role for IFN-g in driving mulitorgan autoimmunity in APECED and devised a personalized, life-transformative intervention for patients nejm.org/doi/full/10.1056/NE…

The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1 | NEJM

Autoimmune polyendocrine syndrome type 1 (APS-1) is a life-threatening, autosomal recessive syndrome caused by autoimmune regulator (AIRE) deficiency. In APS-1, self-reactive T cells escape thymic ...

nejm.org
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Check out the new paper from Kat Mayer-Barber’s lab. Heterogeneity in outcomes of SARS-CoV-2 may be in part due to the recent pulmonary immune history of the host.
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Next article in the lead up to #WorldTBDay 🫁 on March 24: @TaylorForeman19, @danielleobarber et al. show that, in mice, CD30 drives T cell differentiation and is required for host survival of Mycobacterium #tuberculosis infection ➡️ hubs.la/Q02pR6Y-0 #endTB
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We are looking for post-docs interested in studying T cell responses to M. tuberculosis infection. The NIH intramural program is an amazing place to train! Check us out.
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Daniel Barber, PhD retweeted
Eduardo Amaral@Eduardo928669608 Dec 2023
🚨PAPER ALERT: So excited and proud to share my latest work in @NatureMicrobiology about the molecular regulation of lipid peroxidation-mediated #necrosis #ferroptosis in #TB. Please check it out here: nature.com/articles/s41564-0…

BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility

Nature Microbiology - The host transcription factor, Bach1, promotes Mycobacterium tuberculosis pathogenesis by inhibiting protective glutathione metabolism and antioxidant responses that prevent...

nature.com
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Daniel Barber, PhD retweeted
Gaia Trincucci@Gaia_JExpMed10 Nov 2023
Don't miss the latest Insight from @danielleobarber on the recent paper from @joanneflynn19 & collaborators (bit.ly/46P4cZo) regarding the role of CD8+ lymphocytes in early control of tuberculosis in macaques. bit.ly/3QlgvWA

CD8+ lymphocytes are critical for early control of tuberculosis in macaques

This study demonstrates that CD8+ lymphocytes play a critical role in limiting early Mycobacterium tuberculosis infection and spread within lungs and lymph

rupress.org
Journal of Experimental Medicine@JExpMed9 Nov 2023
Early innate role for CD8αα+ cells in #tuberculosis. Daniel L. Barber (@danielleobarber) provides Insights on the recent study (bit.ly/46P4cZo) by @CaylinWinchell, @snyquist2, Lin, @joanneflynn19 et al. bit.ly/3QlgvWA
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Daniel L. Barber discusses the study by @CaylinWinchell, @snyquist2, Lin, @joanneflynn19 et al. (bit.ly/46P4cZo) showing that CD8αα+ lymphocytes have a major role in the innate suppression of Mycobacterium #tuberculosis growth in macaques' lungs bit.ly/3QlgvWA
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