
#Data scientist, #Researcher, Bioinformatician, Photographer, Geek & Bookworm. PhD #AI #LLM @HebrewU @HyadataLab @liniallab @shebaARC
Israel
Joined May 2008
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Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
Dusting off this tweet from April because this gap in shared understanding of LLM capability is *widening*. It's now less "two groups of people speaking past each other" and more a sharp funnel.
- Napkin math somewhere around 6B people (~75% of the population) have barely come in contact with LLMs at all.
- Around 1-2B (~20%) are casual and infrequent users of free-tier ChatGPT-like products. This group sees derpy chatbots and treats them a bit like a better Google search, a writing aid, or etc. Maybe an agent tries to book you a flight. I have non-tech friends who (reasonably, imo) say they have not much use for it at all. Even many professionals outside of math&code are in this tier. For example, execs and many other functions spend a lot of their time talking to other people, so while they understand what is happening intellectually, it is still second-hand and a bit abstract.
- Now we get to professional use of frontier-grade LLMs in math&code. Somewhere around 20M people (0.2%) see first-hand that large, complex projects that used to take them weeks/months can now be completed by agents with a prompt. Building apps, copying apps, translating apps, decompiling apps from binaries... This has all happened very quickly and recently - less than 1 year ago, I was writing code manually by hand, typing memorized computer code commands into a code editor character by character, occasionally pressing Tab to autocomplete a little chunk of code.
- And finally we get to the ~5,000 people (~0.00006%) with access to frontier-grade systems internally. The external world has seen the preview. It looks like swarms of thousands of agents collaborating over weeks on software mega projects: minting zero days, running cyber attacks and defenses at machine speeds, discovering new science, advancing the frontier of mathematics. Things that would have taken top professionals in the industry years of work. Meanwhile, human review and comprehension are starting to fall behind. For example, people are still involved in the "archeology" of the OpenAI-HF incident from many months ago. Mathematicians may be poring over the 722 manuscripts on frontier mathematics for a while.
The funnel is driven by a combination of factors:
1. The impact scales with ambition, problem size, and horizon. A question with a paragraph answer barely stresses the system. You need a reservoir of big, difficult problems that you really care about. This aspect drives the consumer / professional dimension of the funnel.
2. The jaggedness of the system (which I have written about a lot separately). Capability peaks in domains that are digital, verifiable and economically valuable. This is because LLM capability emerges from reinforcement learning on verifiable rewards on a curated environment mixture driven by revenue potential. This aspect primarily drives the area (e.g. math&code) dimension of the funnel.
3. Access. Free-tier, paid-tier, internal.
So this is the weirdness of the moment. The general public has mostly not interacted with these systems. When they have, it looks like a derpy chatbot. The majority of professionals still see only a modest uplift. And a small sliver of professionals are experiencing the vertigo of the curve going vertical. And it is all happening at the same time.
Judging by my tl there is a growing gap in understanding of AI capability.
The first issue I think is around recency and tier of use. I think a lot of people tried the free tier of ChatGPT somewhere last year and allowed it to inform their views on AI a little too much. This is a group of reactions laughing at various quirks of the models, hallucinations, etc. Yes I also saw the viral videos of OpenAI's Advanced Voice mode fumbling simple queries like "should I drive or walk to the carwash". The thing is that these free and old/deprecated models don't reflect the capability in the latest round of state of the art agentic models of this year, especially OpenAI Codex and Claude Code.
But that brings me to the second issue. Even if people paid $200/month to use the state of the art models, a lot of the capabilities are relatively "peaky" in highly technical areas. Typical queries around search, writing, advice, etc. are *not* the domain that has made the most noticeable and dramatic strides in capability. Partly, this is due to the technical details of reinforcement learning and its use of verifiable rewards. But partly, it's also because these use cases are not sufficiently prioritized by the companies in their hillclimbing because they don't lead to as much $$$ value. The goldmines are elsewhere, and the focus comes along.
So that brings me to the second group of people, who *both* 1) pay for and use the state of the art frontier agentic models (OpenAI Codex / Claude Code) and 2) do so professionally in technical domains like programming, math and research. This group of people is subject to the highest amount of "AI Psychosis" because the recent improvements in these domains as of this year have been nothing short of staggering. When you hand a computer terminal to one of these models, you can now watch them melt programming problems that you'd normally expect to take days/weeks of work. It's this second group of people that assigns a much greater gravity to the capabilities, their slope, and various cyber-related repercussions.
TLDR the people in these two groups are speaking past each other. It really is simultaneously the case that OpenAI's free and I think slightly orphaned (?) "Advanced Voice Mode" will fumble the dumbest questions in your Instagram's reels and *at the same time*, OpenAI's highest-tier and paid Codex model will go off for 1 hour to coherently restructure an entire code base, or find and exploit vulnerabilities in computer systems. This part really works and has made dramatic strides because 2 properties: 1) these domains offer explicit reward functions that are verifiable meaning they are easily amenable to reinforcement learning training (e.g. unit tests passed yes or no, in contrast to writing, which is much harder to explicitly judge), but also 2) they are a lot more valuable in b2b settings, meaning that the biggest fraction of the team is focused on improving them. So here we are.
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
The more you read up on ant warfare the more crazy it gets. They have suicide bombers, chemical warfare, and trench warfare. There is a super colony war in California where 30 million ants die every year.
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
Link to the blog:
huggingface.co/blog/nvidia/k…
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
There is a child with a rare disease who is currently suffering and struggling to manage his symptoms. Rare as this is, you can directly help him.
Today we are launching the "Rare Disease, Real Kid" Hackathon, and there are $50,000 in prizes from @AnthropicAI and @awscloud.
We (@huggingface & @Sagebio) are helping this child open his genome and clinical data to the community, so that we can find what's caused his disease and what currently-approved drugs could help him.
I doubt I need to motivate this much further or explain how rare it is for a family to share their child's genome and clinical data, but if you're not sure, consider this:
Until very recently, it wasn't feasible for patients like this to get treatment because their disease was so rare that the economics could never justify the investment. Now, as we've seen, people with rare diseases are starting to be able to find the answers themselves (with the help of AI tools, cheaper sequencing, etc). This kid is not able to do that for himself and neither are his parents, so we're asking you for help. Both for this kid and to prove that it's possible for everyone else suffering from a rare disease.
More details in 🧵.
sagebio-rare-disease-real-ki…
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
idk how i’m down this rabbit hole now, but do people realize this??
muslims literally don’t believe 9/11 was conducted by arab muslims. TO THIS DAY.
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
Must read by all those who think that a real neuron is equivalent to a single weight in a deep learning model.
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
Excellent thread. We always use CLR transformation in metagenomics, so I was confused why it wasn't used in single-cell genomics
Apparently the "CLR" function in the most common single-cell analysis tool failed all the benchmarks because it was implemented incorrectly 😶
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
Replying to @ClaudeDevs
This is the workflow I want beginners to copy: do not ask the agent to finish, ask it to prove. Plan, change, test, summarize what failed, then fix. That feedback loop is where Claude Code becomes a teammate instead of a guessing machine.
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
The world is about to get a master class in antisemitism.
Israel's minister Ben Gvir's behavior towards the flotilla activists was unacceptable. I said so myself.
World leaders all posted angry denunciations of the Israeli government and summoned Israeli ambassadors for a dressing down.
Here, the same activists are receiving much more brutal treatment at the hands of the Spanish government. What we won't see however is an international outcry against the Spanish government.
This imbalance isn't due to the vagaries of international diplomacy. People hold the Jewish state to a higher standard than they do any other state, and fundamentally it's due of bigotry and hatred.
@AnitaAnandMP
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
Pancreatic cancer is one of the most dire diagnoses in medicine with few available treatments. Until now, thanks to university research, including @UCSF scientists, and federal investment in science research. Read about this huge breakthrough via @nytimes nyti.ms/4wfziXs
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
JEPA-DNA: Grounding Genomic Foundation Models through Joint-Embedding Predictive Architectures
1. The paper introduces JEPA-DNA, a novel pre-training framework that addresses a critical limitation in Genomic Foundation Models (GFMs): the "granularity trap" where models over-focus on local nucleotide patterns while missing broader biological function.
2. Unlike traditional MLM and NTP objectives that reconstruct individual tokens, JEPA-DNA predicts latent representations of masked genomic segments in embedding space, forcing the model to capture high-level functional semantics rather than just sequence syntax.
3. The architecture combines a context encoder, target encoder (with EMA updates), and predictor head, using a [CLS] token to supervise global sequence representation through cosine similarity loss in latent space.
4. JEPA-DNA is uniquely versatile—it can serve as a standalone pre-training objective or as continual pre-training to "ground" existing GFMs, and it extends naturally across both MLM and NTP paradigms as well as different backbone architectures.
5. The method incorporates variance and covariance regularization (VICReg-style) to prevent representation collapse, ensuring diverse and informative embeddings without requiring negative samples or complex data augmentations.
6. Empirical results show consistent improvements over DNABERT-2 baselines across supervised tasks (linear probing) and zero-shot inference, with notable gains in splice site prediction (+4.8%), coding pathogenicity (+6.0%), and Mendelian trait prediction (+7.3%).
7. The work represents the first application of Joint-Embedding Predictive Architecture to raw genomic sequences, establishing a path toward foundation models that understand not just the "alphabet" of DNA but its underlying functional logic.
📜Paper: arxiv.org/abs/2602.17162
#JEPADNA #GenomicFoundationModels #ComputationalBiology #Bioinformatics #MachineLearning #DeepLearning #Genomics #SelfSupervisedLearning #JEPA #DNABERT
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
Announcing our preprint: Predicting evolutionary rate as a pretraining task improves genome language model representations: biorxiv.org/content/10.64898…
Genome language models (gLMs) have the potential to further understanding of regulatory genomics without requiring labeled data...
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
🧬Tool Alert: wgbstools! A computational suite for high-throughput methylation sequencing 📉 Ultra-compact storage 🔍 Single-molecule analysis 🎯 genome segmentation & DMR ID 💻 github.com/nloyfer/wgbs_tool… 📄 Paper: life-science-alliance.org/co… @HebrewU
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
I'm Boris and I created Claude Code. I wanted to quickly share a few tips for using Claude Code, sourced directly from the Claude Code team. The way the team uses Claude is different than how I use it. Remember: there is no one right way to use Claude Code -- everyones' setup is different. You should experiment to see what works for you!
Dan Ofer (✈️ ICML-26 Was @Worldcon) retweeted
A few random notes from claude coding quite a bit last few weeks.
Coding workflow. Given the latest lift in LLM coding capability, like many others I rapidly went from about 80% manual+autocomplete coding and 20% agents in November to 80% agent coding and 20% edits+touchups in December. i.e. I really am mostly programming in English now, a bit sheepishly telling the LLM what code to write... in words. It hurts the ego a bit but the power to operate over software in large "code actions" is just too net useful, especially once you adapt to it, configure it, learn to use it, and wrap your head around what it can and cannot do. This is easily the biggest change to my basic coding workflow in ~2 decades of programming and it happened over the course of a few weeks. I'd expect something similar to be happening to well into double digit percent of engineers out there, while the awareness of it in the general population feels well into low single digit percent.
IDEs/agent swarms/fallability. Both the "no need for IDE anymore" hype and the "agent swarm" hype is imo too much for right now. The models definitely still make mistakes and if you have any code you actually care about I would watch them like a hawk, in a nice large IDE on the side. The mistakes have changed a lot - they are not simple syntax errors anymore, they are subtle conceptual errors that a slightly sloppy, hasty junior dev might do. The most common category is that the models make wrong assumptions on your behalf and just run along with them without checking. They also don't manage their confusion, they don't seek clarifications, they don't surface inconsistencies, they don't present tradeoffs, they don't push back when they should, and they are still a little too sycophantic. Things get better in plan mode, but there is some need for a lightweight inline plan mode. They also really like to overcomplicate code and APIs, they bloat abstractions, they don't clean up dead code after themselves, etc. They will implement an inefficient, bloated, brittle construction over 1000 lines of code and it's up to you to be like "umm couldn't you just do this instead?" and they will be like "of course!" and immediately cut it down to 100 lines. They still sometimes change/remove comments and code they don't like or don't sufficiently understand as side effects, even if it is orthogonal to the task at hand. All of this happens despite a few simple attempts to fix it via instructions in CLAUDE . md. Despite all these issues, it is still a net huge improvement and it's very difficult to imagine going back to manual coding. TLDR everyone has their developing flow, my current is a small few CC sessions on the left in ghostty windows/tabs and an IDE on the right for viewing the code + manual edits.
Tenacity. It's so interesting to watch an agent relentlessly work at something. They never get tired, they never get demoralized, they just keep going and trying things where a person would have given up long ago to fight another day. It's a "feel the AGI" moment to watch it struggle with something for a long time just to come out victorious 30 minutes later. You realize that stamina is a core bottleneck to work and that with LLMs in hand it has been dramatically increased.
Speedups. It's not clear how to measure the "speedup" of LLM assistance. Certainly I feel net way faster at what I was going to do, but the main effect is that I do a lot more than I was going to do because 1) I can code up all kinds of things that just wouldn't have been worth coding before and 2) I can approach code that I couldn't work on before because of knowledge/skill issue. So certainly it's speedup, but it's possibly a lot more an expansion.
Leverage. LLMs are exceptionally good at looping until they meet specific goals and this is where most of the "feel the AGI" magic is to be found. Don't tell it what to do, give it success criteria and watch it go. Get it to write tests first and then pass them. Put it in the loop with a browser MCP. Write the naive algorithm that is very likely correct first, then ask it to optimize it while preserving correctness. Change your approach from imperative to declarative to get the agents looping longer and gain leverage.
Fun. I didn't anticipate that with agents programming feels *more* fun because a lot of the fill in the blanks drudgery is removed and what remains is the creative part. I also feel less blocked/stuck (which is not fun) and I experience a lot more courage because there's almost always a way to work hand in hand with it to make some positive progress. I have seen the opposite sentiment from other people too; LLM coding will split up engineers based on those who primarily liked coding and those who primarily liked building.
Atrophy. I've already noticed that I am slowly starting to atrophy my ability to write code manually. Generation (writing code) and discrimination (reading code) are different capabilities in the brain. Largely due to all the little mostly syntactic details involved in programming, you can review code just fine even if you struggle to write it.
Slopacolypse. I am bracing for 2026 as the year of the slopacolypse across all of github, substack, arxiv, X/instagram, and generally all digital media. We're also going to see a lot more AI hype productivity theater (is that even possible?), on the side of actual, real improvements.
Questions. A few of the questions on my mind:
- What happens to the "10X engineer" - the ratio of productivity between the mean and the max engineer? It's quite possible that this grows *a lot*.
- Armed with LLMs, do generalists increasingly outperform specialists? LLMs are a lot better at fill in the blanks (the micro) than grand strategy (the macro).
- What does LLM coding feel like in the future? Is it like playing StarCraft? Playing Factorio? Playing music?
- How much of society is bottlenecked by digital knowledge work?
TLDR Where does this leave us? LLM agent capabilities (Claude & Codex especially) have crossed some kind of threshold of coherence around December 2025 and caused a phase shift in software engineering and closely related. The intelligence part suddenly feels quite a bit ahead of all the rest of it - integrations (tools, knowledge), the necessity for new organizational workflows, processes, diffusion more generally. 2026 is going to be a high energy year as the industry metabolizes the new capability.




























