Deva Situnayake (@devasitunayake) profile picture
Joined September 2012
Brilliant speech by Marcela Ferrada about #VEXAS at #EULAR2024 Key features to keep in mind ARE NOT gender and age of patients but ARE 🔴 unusual inflammatory features 🔴 elevated inflammatory markers 🔴 elevated MCV 🔴diagnosis is by genetic testing🔴 MP
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Excellent talk (as usual) of @HelenLachmann in #EULAR2024 on TRAPS syndrome. She raised awaireness to be cautious in presence of R92Q variant in TNFRSF1A which may be associated more likely with SURF/USAID than prototypic TRAPS
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The epi of Behcets in CPRD & linked HES in news at #EULAR2024 Increasing prevalence, incidence stable Increased risk of BD in the presence of phenotypically linked MHC1 diseases Median time to diagnosis shortest for Genital ulceration! @devasitunayake @JohtChandan @Janetbirdope
#Behcet’s #syndrome is increasing in the UK ? ⬆️ Detection ? Changing population demographics ? Other reasons Poster discussion POS0258 #EULAR2024 @RheumNow @eular_org @Pr1yankaC
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Deva Situnayake retweeted
We totally agree with this. Please RT if you do too.
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Vast numbers of epidemiological papers basically say ‘this definitely isn’t in any way causal evidence, but here are some policy interventions we think are supported by this not-causal evidence’. And I don’t think that’s very helpful. Some thoughts: kucharski.substack.com/p/epi…
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Deva Situnayake retweeted
Pleased to share our review in the @TheLancetRheum discussing current insights and future frontiers for inflammatory #myopathies. Full text and pictures accessible here! tinyurl.com/y25mhnnm
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#HappyNewYear2024 I decided to ask a chosen few their realistic personal hope for 2024 The few are those who I have a connection with whether it’s been recent or longstanding! All are worth sharing 🧵
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Deva Situnayake retweeted
Rejoin the EU.
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🔹 Immune-Mediaded Inflammatory Diseases (IMIDs) & Non-Alcoholic SteatoHepatitis (NASH) 🔹 #RheumatoidArthritis #Psoriasis #JIA #Crohns #UlcerativeColitis #AnkylosingSpondylitis #Uveitis #Sjögren's #Lupus #Scleroderma #HidradenitisSuppurativa #Vasculitis #Behcet 👉🏻 #APsDate 2019
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Deva Situnayake retweeted
Gave my first talk on #Behçet this week! Proud to highlight work of a former research trainee: Femoral vein wall thickness: A new diagnostic tool for #Behçet’s disease @drfatmaalibaz #vasculitis @HanerDireskenel doi.org/10.1093/rheumatology…
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Deva Situnayake retweeted
✨ Phenomenal review of #Behcet’s by Dr. Seyahi #IRACON21 For Venous/Arterial Thrombosis 🎯 Immunesuppression is KEY! 👉 Anti-TNF 1st 🎯 Anticoag controversial but added if 👉 Low bleeding risk 👉 NO Pulmonary Artery aneurysm 👉 DOACs may be reasonable
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Deva Situnayake retweeted
#Sarcoidosis versus #Behcet Eyes Too much, but good to know sometimes Go Anterior to back of eyes #RheumTwitter #MedTwitter
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📢 Hot of the press! Latest @Official_ASAS publication reiterates pivotal consensus on #axSpA nomenclature: "axSpA" as the universal term; "r-axSpA" preferred to "AS". Next steps: consistent adoption in educational materials, manuscripts, presentations, ICD-coding integration.
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Deva Situnayake retweeted
It’s here and already over the harbour already! 😳 #polperro #StormCiaran
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ChatGPT use shows that the grant-application system is broken nature.com/articles/d41586-0…
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1/ Reliable imputation of spatial transcriptome with uncertainty estimation and spatial regularization buff.ly/3rQsYtd
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This 8000 word paper by brilliant @UCSFMedicine M3 @anushka_walia4 is going to be the most interesting thing you read about PFS, EFS, DFS in oncology this year Even if you think you know these endpoints well, I promise you will learn something new 🧵🧵 nature.com/articles/s41571-0…
In a new Perspective, Walia, Tuia & @VPrasadMDMPH discuss the adoption of composite end points in oncology, their pro and cons, and advocate for separate reporting of component events to enable a better understanding of cancer biology and trial results: nature.com/articles/s41571-0…
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Robert De Niro’s full statement on Trump. Please read and let me know your thoughts: I’ve spent a lot of time studying bad men.  I’ve examined their characteristics, their mannerisms, the utter banality of their cruelty. Yet there’s something different about Donald Trump. When I look at him, I don’t see a bad man. Truly. I see an evil one. Over the years, I’ve met gangsters here and there. This guy tries to be one, but he can’t quite pull it off. There’s such a thing as “honor among thieves.” Yes, even criminals usually have a sense of right and wrong.  Whether they do the right thing or not is a different story — but — they have a moral code, however warped. Donald Trump does not. He’s a wannabe tough guy with no morals or ethics. No sense of right or wrong. No regard for anyone but himself — not the people he was supposed to lead and protect, not the people he does business with, not the people who follow him, blindly and loyally, not even the people who consider themselves his “friends.” He has contempt for all of them. We New Yorkers got to know him over the years that he poisoned the atmosphere and littered our city with monuments to his ego.  We knew first hand that this was someone who should never be considered for leadership.  We tried to warn the world in 2016. The repercussions of his turbulent presidency divided America and rattled New York City beyond imagination.  Remember how we were jolted by crisis in early 2020, as a virus swept the world. We lived with Donald Trump’s bombastic behavior every day on the national stage, and we suffered as we saw our neighbors piling up in body bags. The man who was supposed to protect this country put it in peril, because of his recklessness and impulsiveness. It was like an abusive father ruling the family by fear and violent behavior.  That was the consequence of New York’s warning getting ignored. Next time, we know it will be worse. Make no mistake: the twice-impeached, 4-time indicted Donald Trump is still a fool. But we can’t let our fellow Americans write him off like one. Evil thrives in the shadow of dismissive mockery, which is why we must take the danger of Donald Trump very seriously. So today we issue another warning. From this place where Abraham Lincoln spoke — right here in the beating heart of New York — to the rest of America: This is our last chance. Democracy won’t survive the return of a wannabe dictator. And it won’t overcome evil if we are divided. So what do we do about it?  I know I’m preaching to the choir here.  What we’re doing today is valuable, but we have to take today into tomorrow – take it outside these walls.   We have to reach out to the half of our country who have ignored the hazards of Trump and, for whatever reason, support elevating him back into the White House.  They’re not stupid, and we must not condemn them for making a stupid choice.  Our future doesn’t just depend on us. It depends on them. Let’s reach out to Trump’s followers with respect.  Let’s not talk about “democracy.”  “Democracy” may be our holy grail, but to others it is just a word, a concept, and in their embrace of Trump, they’ve already turned their backs on it.  Let’s talk about right and wrong.  Let’s talk about humanity.  Let’s talk about kindness.  Security for our world.  Safety for our families.  Decency.  Let’s welcome them back.  We won’t get them all, but we can get enough to end the nightmare of Trump, and fulfill the mission of this “Stop Trump Summit.”
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EULAR recommendations for the management of systemic lupus erythematosus: 2023 update 🔴 HCQ for all 5 mg/kg/day 🔴 GC as ‘bridging therapy’ or maintenance ≤ 5 mg/day 🔴 Prompt initiation of immunosuppressive and/or biological agents @eular_org 👉 bit.ly/45ulfyD
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