💭Striving to understand how cells communicate with their environment 🔍Focusing on TGF-beta in development and cancer @thecrick 🧑🔬Run by lab members
London, England
Joined December 2018
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@AmoyelLab have generated transgenic #Drosophila lines for tissue specific expression (with and without a T2A-His2Av-mCh) and our biosensor also displays an improvement in later developing larval eye discs
3/6
We noticed in the #zebrafish embryo that the Erk-dependent pattern of Erk-KTR nucleocytoplasmic shuttling is masked by additional regulation by Cdk1. The removal of a putative cyclin binding site significantly improves the Erk specificity of the biosensor.
2/6
Follow-up of our previous work from 2018. We show that pathogenic mutation of ACVRI is enough to cause receptors clustering and auto-activation. The resulting signalling increases in duration and intensity. Well done @AnaRamachandran @MerimaMehic2 @ila_gori and all authors!
Our paper is out! 30 years after the classic works of Boyd, Laiho, Wrana, Ebner, ten Dijke, Weis-Garcia, Luo and others, and building on our 2018 paper, we show activation of TGF-β family signalling dependent on only the kinase activity of type I receptors doi.org/10.15252/embj.202010…
Congratulations @izziebradley for successfully defending your PhD thesis this afternoon! Izzie’s work focused on understanding BMPs role in forebrain identities in zebrafish embryos. We are so proud of you Doctor Bradley ✨
Today we wear blue for World diabetes day!
"Let's celebrate how far we’ve come and look to the future...to fight for a world where diabetes can do no harm"
#WorldDiabetesDay #WorldDiabetesDay2019
