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Incredibly proud to share that I recently joined @UCSF_BTS @UCSF as an Assistant Professor! This means that the Calderon Lab is now open!
Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳
ALT Me outside my lab building holding my UCSF badge
ALT Unraveling a giant poster that says "Calderon Lab est. 2024"
Diego Calderon retweeted
Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!
Diego Calderon retweeted
Exciting day for DNA Typewriter w/ 2 papers from the lab & SeaHub out today :)
1. Mouse lineage from E0 to E13.5
science.org/doi/10.1126/scie…
2. A fluctuation test for gastruloid heterogeneity
cell.com/cell/fulltext/S0092…
Paper #1 covered in quoted thread. More on paper #2 here. 1/n
Diego Calderon retweeted
My department at UCSF is hiring new faculty focused on biomolecular engineering. If that's how you think of yourself, apply! It's a great place to be a scientist.
aprecruit.ucsf.edu/JPF06213
Diego Calderon retweeted
1/ Our new paper is out in @CellGenomics 🎉
We introduce FastGxC, a fast and powerful method for mapping eQTLs in bulk and single cell sequencing studies and quantifying how their effects vary across tissues and cell types.
cell.com/cell-genomics/fullt…
Diego Calderon retweeted
🚀Excited to share our new paper @Nature! We developed PerturbFate platform to discover how diverse genetic perturbations converge on a shared cell state, and key molecular programs driving it, led by our incredible student @xu_zxu from @RockefellerUniv.
rdcu.be/fdC14
Diego Calderon retweeted
Our bat–mouse limb paper is now on bioRxiv! 🦇🧬biorxiv.org/content/10.64898…
This was a collaborative effort across the @NadavAhituv, @NicolaIlling, @DoritHockman, Guy Kelman, Tommy Kaplan and my lab at @WashUGenetics
Highlights below ↓
Diego Calderon retweeted
New preprint! @JShendure @CXchengxiangQIU Can we learn regulatory grammars of human cell types we'll never be able to profile - by training on mouse development and transferring across 241 mammalian genomes?biorxiv.org/content/10.64898…
Diego Calderon retweeted
Stoked to announce that I’m starting a lab as an Assistant Professor in the School of Biomedical Engineering and Centre for Brain Health at UBC!
mcdiarmid-lab.sbme.ubc.ca
Recruiting at all levels - please share the word!
Cheers and happy long weekend all!
Diego Calderon retweeted
‼️The @UCSF Broad Stem Cell Center & Department of #Surgery is recruiting faculty to help advance the future of Gene Editing. This position focuses on the Development of delivery tools for Gene Editing to enable cutting-edge gene therapies.
Apply below👇aprecruit.ucsf.edu/JPF05914
Diego Calderon retweeted
Pregnancy loss is common in humans, and chromosome abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that common variation in meiosis genes influences recombination and aneuploidy risk.
@saracarioscia @aabiddanda
nature.com/articles/s41586-0…
Diego Calderon retweeted
Ribosomal RNA (rRNA) genes are found in hundreds of copies in the human genome.
Do sequence variations in these paralogs change the ribosome function? Yes!
I am excited to share our new preprint @mbarnalab @jkpritch in collaboration with Calico:
medrxiv.org/content/10.1101/…
1/8
Diego Calderon retweeted
Thrilled to share I’ve started my lab at Dartmouth’s Geisel School of Medicine! We focus on mapping cellular trajectories & TF networks in development and Mendelian disorders, exploring new therapies. Join us—postdocs, grads, and scientists welcome! sites.dartmouth.edu/qiulab/
Diego Calderon retweeted
Stoked to share our latest work entitled “Large-scale discovery of neural enhancers for cis-regulation therapies”
shorturl.at/H3Qww
This is an enormous team effort that I had the honour of spearheading with Nick Page and @FloChardon
Tweetorial below.
Diego Calderon retweeted
Online Now: Combinatorial mapping of E3 ubiquitin ligases to their target substrates dlvr.it/THqW1q
Diego Calderon retweeted
Please re-tweet:
We are hiring! Assistant Professor in statistical genetics. Also, hiring a postdoc. Reach out to hear more. Also, if you’ll be at #ASHG24 #ASHG2024, we could meet. careers.ashg.org/jobs/207625…
Diego Calderon retweeted
Excited to share my PhD work in @Agnelsfeir’s lab describing a method to engineer mitochondrial DNA deletions in human cells and our exploration of how cellular metabolism and transcription respond to deletion heteroplasmy. biorxiv.org/content/10.1101/… 1/19
Diego Calderon retweeted
New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4
Diego Calderon retweeted
This is happening tomorrow! Still some time to sign up! Both in-person and online opportunities!
xitter.cf/hjpimentel/status/1844…
Interested in math and computational biology? The @CompMedUCLA PhD program is having our info session On Wed 16th at 3-4P PST. Come learn about our program and hear from some of our faculty. RSVP:
forms.gle/qozQj6aEmc4PPnVWA
Diego Calderon retweeted
Thinking about a PhD using computational power to answer pressing problems in biology and health? @UCSF Biological and Medical Informatics PhD program is recruiting for Fall 2025! Join our info session next Monday Oct 21: bmi.ucsf.edu/admissions.
