Professeur, Université Laval, 🇨🇦. Genome Editing Machines and Uses Thereof - Ingénierie Ciblée du Génome. Goalie ∞Account managed by parents∞
Québec, Canada
Joined February 2014
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The entire thread is worth reading. From my understanding, it aligns with the direction the FDA is taking for rare diseases
Excited to share full data for BEAM-301 in GSD1a, covering the first two dose cohorts
** Importantly, 2/3 patients at the 2nd dose level achieved maximum fasting duration and no longer require corn starch supplementation after a single dose of BEAM-301
globenewswire.com/news-relea…
🥅Doyonlab🥅 retweeted
1/4 Today Merck reported that remigromig (MK-3000, formerly EYE103), a tri-specific Wnt agonist antibody, met its primary endpoint in the pivotal ph. 3 BRUNELLO trial in diabetic macular edema merck.com/news/mercks-remigr…
🥅Doyonlab🥅 retweeted
Inspired by Gibson cloning, we describe prime assembly, now published, for in cellulo targeted integration of gene-sized DNA fragments using prime editing. nature.com/articles/s41586-0…
🥅Doyonlab🥅 retweeted
Online Now: Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation dlvr.it/TR0K7r
"...the costs of journal publishing go far beyond dollars..."
Open letter to HHMI on their Immediate Access to Research Policy by me and @PracheeAC thescientistpapers.substack.…
I will need to read this paper a few more times, but it is not only spectacular, it is loaded with secrets regarding in vivo editing. Thanks a lot!
Led by @sharan_janjuha with @AcuitasTx @pardi_lab, our Nat Biomed Eng paper is out 🧬
We use in situ sequencing to read base & prime editing directly in tissues - from mouse brain (AAV) to macaque liver (RNA–LNP)-mapping lobules & redosing. Open access: rdcu.be/eHcN1
🥅Doyonlab🥅 retweeted
The fact that someone (here @PracheeAC) has to write an op-ed about what a scam journal publishing is every few years is such an embarrassment for science - a sign that its practitioners simply do not prioritize discovery and progress for the public good. wsj.com/opinion/academic-pub…
🥅Doyonlab🥅 retweeted
Right now is the best chance the scientific community has ever had to end the artificial scarcity of academic journals.
Check out my new op-ed urging @NIH @NIHDirector_Jay to disallow taxpayer dollars towards journal publication fees — something both publishers and scientists have played a role in perpetuating.
The last day for public comment on this topic is Monday, Sept 15. It’s time to unleash science.
Links in 🧵
🥅Doyonlab🥅 retweeted
Gift link to the op-ed:
wsj.com/opinion/academic-pub…
🥅Doyonlab🥅 retweeted
How to be a scientist in a post-journal world open.substack.com/pub/thesci…
« There is not, has never been, and never will be, a system that can absolve you of the need to read papers, use data, conduct experiments, think about results, and share insights you find valuable. » 🎯
🥅Doyonlab🥅 retweeted
L’arrivée de l'intelligence artificielle avec les outils comme ChatGPT a chamboulé l’enseignement supérieur. Rapidement, nous avons mobilisé tous les acteurs du réseau et experts pour convenir d'une vision commune sur une utilisation responsable et sécuritaire dans nos établissements.
L’IA fait désormais partie du paysage, il y a une opportunité d'en tirer avantage, tout en étant conscient des limites de ces nouvelles technologies.
Je suis donc très fière d'annoncer le résultat de ces importants travaux: deux outils qui permettront d'aider nos établissements à s'adapter à cette réalité et faire des choix éclairés!
Les détails dans le communiqué: newswire.ca/fr/news-releases…
Un bel article de vulgarisation scientifique de nos travaux.
Un outil pourrait modifier les globules rouges pour obtenir du sang « sur mesure » lapresse.ca/actualites/scien… via @lp_lapresse
Un bel article de vulgarisation scientifique de nos travaux
nouvelles.ulaval.ca/2025/05/…
🥅Doyonlab🥅 retweeted
When we started thinking of CRISPR-dependent base editing as a potential therapeutic strategy to correct a mutation causing an ultra-rare monogenic disorder we did not quite know where to start!! (1/3)
frontiersin.org/journals/gen…
A fun project on editing HSPCs. Great experience publishing at Human Molecular Genetics
CRISPR-Cas9-driven antigen conversion of clinically relevant blood group systems academic.oup.com/hmg/article…