cryo-ET and enveloped viruses. Principal Investigator @ School of Life Sciences, Tsinghua University, Beijing.
Beijing
Joined May 2016
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We are proud to announce FlyTomo, a streamlined software for on-the-fly cryo-ET data processing and diagnosis. It's recently published in Nat. Commun. Please use it & give us feedback! nature.com/articles/s41467-0…
Our work presents the first cryo-ET image of the authentic #Mpox virus and its 3D reconstruction. It's a huge virus. Details in: rdcu.be/dXFp2
Our new work is online in PNAS today. In this work, electron-beam & PFA inactivated Delta virions were imaged by cryo-ET and compared; homotypic fusion were found between the virions. In situ architecture and membrane fusion of SARS-CoV-2 Delta variant pnas.org/doi/10.1073/pnas.22…
Looking forward to speak at the International conference "#COVID19, Advances and Remaining Challenges", 29 Sep.-1 Oct. 2021, organised by @institutpasteur @PasteurVirology covid19.conferences-pasteur.…
I draw Fig.1 to pay tribute to T.Baker and S.Fuller, two pioneer&masters in cryoEM structural virology. S.Fuller was a founder of OPIC @OxfordStrubi, which cultivated #cryoET virology, @BriggsGroup, Guilia and many younger #cryoET generations, including me
authors.elsevier.com/a/1djZu…
My review is online today on @TrendsBiochem, highlighting the recent advances in in-situ structural virology and cryo-ET method developments. The efforts shed light on the assembly and intracellular activities for some most threatening viruses. authors.elsevier.com/a/1djZu…
Ancient great wall surrounded by peach flowers, found my peace in the mountains after a week of meetings.
the Sai Lab retweeted
Scientists have revealed what #COVID-19 really looks like. The virus has infected nearly 100 million people, killing more than 2 million worldwide.
"Seeing is believing. The public is likely to ignore the danger, if no one is able to see the dangerous yet very small pathogens."
the Sai Lab retweeted
#COVID19 has infected nearly 100 million people and killed over 2 million worldwide. What does it really look like?
Scientists and visual experts from China, Saudi Arabia and Austria have created detailed 3-D images of the #coronavirus. Check out video: xhne.ws/oMm84
What does a virus actually look like? Stunning video made based on our paper of the intact #SARS_CoV_2 strucutre, check youtu.be/7g0fkC3CywM
Nature Research webcast and @thermofisher are hosting my web talk on 12th Nov, on the Molecular Architecture of the SARS-CoV-2 Virus. Everyone is welcome! workcast.com/register?cpak=3… cell.com/cell/fulltext/S0092…
Virus structure made to the home page of #NYTimes, absolutely stunning! We read this on today's group meeting, used this opportunity to tell my students how much work from @carlzimmer alone was spent on this article. Great work, enjoyed every word.
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A great summary of recent structural findings on #sars_cov_2, written by @carlzimmer and published on #nytimes. Our recent work on the intact virus was mentioned in the beginning of the story.
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the Sai Lab retweeted
We know quite a bit about how #COVID19 virus works: sciencemuseumgroup.org.uk/bl…
Here's the coronavirus unveiled, by @carlzimmer and featuring great @drlisai images of #COVID19 nytimes.com/interactive/2020…
This 3Dprint of our authentic #SARS_CoV_2 structure costed a fortune. I brainstormed on how to print it, even had a meeting with the company. They failed a few tries and finally made it. Wondered if they ever made any profit from it. Perfect for education. doi.org/10.1016/J.CELL.2020.…
In case you are curious about the spikes: the red ones are the RBD down spikes, pink ones are one RBD up; the orange ones are postfusion spikes. The spikes are movable around their stems. Everything is in authentic scale and location as the real #SARS_CoV_2 virus!
Plus, it's a 2 million times magnified virus, representing the authentic look of #SARS_CoV_2
Our work on the authentic #SARS_CoV_2 is online in Cell today! We revealed both the spikes from the virion surface and the structure & assembly of the RNP in the virion. We've even made 3D print of our virus structure. So pround of my lab @Tsinghua_Uni. doi.org/10.1016/j.cell.2020.…
Here is a quick video summary showing the cryo-ET of #SARS_CoV_2 and in situ reconstruction of the virus architecture. Imaging and data processing were done in @Tsinghua_Uni. We will share the virus model for 3D printing for education purposes soon.
doi.org/10.1101/2020.07.08.1…