AP/CP Pathologist @KingsCollegeLon Trained @MayoClinicPath @Yalepathology @NU_pathology | Digital Pathology | AI in Medicine | Sharing real diagnostic cases
Joined October 2025
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Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Skin biopsy from sun damaged skin in elderly man. Diagnosis? Answer youtu.be/1gPZDfMabGg #pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Inflamed skin nodule. Diagnosis?
Answer ✅ youtu.be/PzVGVD5_dyQ
#pathology #pathologists #pathTwitter #dermpath #dermatology #dermatologia #dermtwitter
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
🔬 Leeds Lymphoma Course @Dr_HebahAli & @pgopinathpg Practical • Interactive • International
A comprehensive online course in lymphoma diagnostics for residents & pathologists
🎓 3 days | Expert faculty
💬 Live cases + Q&A | Recordings
🔗 Book now ow.ly/m4Qp50Zyt39
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Sex-dimorphic roles of Histone Variant H2A.Z in #AlzheimersDisease
🗒️In Human👤 hippocampus
H2AZ1 & H2AZ2⬆️, but overall H2A.Z chromatin occupancy⬇️in ♀️not ♂️AD patients
"more than half of the genes that gained H2A.Z in male patients lost H2A.Z in female patients"
"unique sites in each sex were primarily intergenic"
🗒️In 5xFAD Mice🐭
H2AZ1 knockdown (AAVDJ-U6-shH2AZ1, Stereotaxic injection into CA1 at 2.5 mo) has Opposite function in ♂️vs♀️
👉Memory (object location memory, only observable at 3 mo)
👉Insoluble Aβ42 (8 mo)
👉Soluble pTau217 (8 mo)
+H2A.Z ChIP in 4- & 8-mo 5xFAD ♀️♂️🐭
"many genes that were modified in human female patients were also modified in female 5xFAD mice (3,127 of 7,012)"
GSK3B/MAPT/PTPRS
@IvaZovkic @NeuroCellPress 2026
sciencedirect.com/science/ar…
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Flat Epithelial Atypia (FEA), left pic
Focal Atypical Ductal Hyperplasia (ADH), right pic
Dr. Allison. 2026 Diagnostic Pathology Update #USCAP #pathology #PathX
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Understanding and clinical approach to early T-cell precursor acute lymphoblastic leukemia pubmed.ncbi.nlm.nih.gov/4286… #leusm
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Histologic features favoring CMV hepatitis in liver allograft biopsies with overlapping rejection-type injury
➡️Microgranulomas
➡️Neutrophilic microabscesses
Difficult topic, covered by IJSP. Read more here 👉🏼 tinyurl.com/5enfmwv3
#PathTwitter #GIPath #MedicalLiverPath
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Adamantinoma-like Ewing Sarcoma: An Underrecognized Mimicker in the He...
sciencedirect.com/science/ar…
Our case series on a rare diagnosis on the head neck!
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
دشّنت جمعية التثقيف الصحي «ثقف» بالتعاون مع مستشفى كينغز كوليدج لندن @KCHLSAUDI مبادرة
«تبرعك بدمك.. عطاء وأثر»،
برعاية صاحب السمو الملكي الأمير فيصل بن سلطان بن ناصر آل سعود، رئيس مجلس إدارة الجمعية.
وتأتي المبادرة تعزيزًا لثقافة التبرع بالدم، وترسيخًا لقيم العطاء والمسؤولية المجتمعية، وإسهامًا في دعم الاحتياج المستمر للدم وإنقاذ الأرواح. 🩸
#تبرعك_بدمك_عطاء_وأثر
#جمعية_ثقف
#كينغز_كوليدج_لندن
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Hashimoto can fool you.
Clear nuclei ≠ cancer.
Grooves ≠ PTC.
If it’s diffuse, patchy, and non-encapsulated
→ it’s thyroiditis, not a tumor.
Don’t overcall.
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
At first glance: NIFTP
Encapsulated, follicular, PTC-type nuclei
Then you scan more slides…
Another focus
Then another
No strict cutoff exists
But once reproducible foci appear across the gland
This is not a solitary neoplasm anymore
→ Multifocal FVPTC
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
STAT6 IHC: A new biomarker for Eosinophilic Esophagitis? Read more here 👉 doi.org/10.5858/arpa.2025-04…
#CAP #Archives #Pathology #GIPathology #EoE
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Post-gastric bypass patient with a 5 cm perigastric mass. EUS-FNA favored a rare postoperative fibroblastic/myofibroblastic proliferation, later confirmed on resection. IHC: DOG1–, KIT–, CD34–, S100–, SOX10–, ALK–, Desmin–, Ki-67 low, SMA weak+. #Pathology #EUS #Cytology
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
Strange β-catenin pattern! A rare post-gastric bypass reparative fibroblastic/#myofibroblastic #pseudotumor showed diffuse cytoplasmic with only weak nuclear β-catenin staining, a potential pitfall that can mimic desmoid fibromatosis. Morphology always comes first #Pathology #EUS
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
One biomarker tells part of the story.
ER + PR together tell much more.
Understanding concordance patterns helps identify expected biology, recognize red flags, and know when a result deserves a second look.
ER/PR concordance algorithm 👇
#BreastPathology #IHC #BreastCancer
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
The closest view can make all the difference in reaching a diagnosis
PAUCIBACILLARY LEPROSY at the tuberculoid pole
#infectious #medicine #dermatology #pathology #dermpath
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
🧠 Second-opinion case (Gyn Path)
32-yo | Myomectomy for “degenerated fibroid”
Specimen arrives fragmented (already a clue).
Smooth muscle tumor with
• Focal infiltrative borders
• 5 mitoses /10 HPF
• Focal atypia
• No tumor cell necrosis
STUMP… or you push it higher
Ibrahim Mansoor FCAP, FIAC, FACHDM retweeted
A cervical cancer pitfall worth remembering:
This case turned out to be mesonephric carcinoma of the cervix (HPV-independent) — a rare tumor that can lack surface dysplasia, show non–block p16, and mimic benign glands.
A reminder that HPV-only screening won’t detect everything.
