david 为 zhou (@dvwz) header
david 为 zhou (@dvwz) profile picture

david 为 zhou

@dvwz

translating and interpreting M/EEG brain signals; postdoc @CarneyInstitute w/ @drstephjones; previously @mitbrainandcog, @MGH_CNTR, @MGHanesthesia, @CMUcompbio

 queens → boston
linktr.ee/dvwz
Joined May 2008
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Testing circuit-level theories of consciousness in humans doi.org/10.1016/j.tics.2025.… #neuroscience
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It's a privilege to be part of this new review in Trends in Cognitive Sciences @CellPressNews: Testing circuit-level theories of consciousness with modern neuroimaging and biophysical modeling 🧵 cell.com/trends/cognitive-sc…
Testing circuit-level theories of consciousness in humans

Testing circuit-level theories of consciousness in humans

Our understanding of the neural basis of consciousness is mostly restricted to large-scale brain activity patterns as measured by methods such as functional magnetic resonance imaging (fMRI) and...

cell.com
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The same circuit principles apply across disorders of consciousness, dementia, and psychiatric conditions. These aren't separate disorders but variations in how circuit disruptions manifest as symptoms in conscious experience.
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It's time to move beyond abstract debates and build a mechanistic systems neuroscience that bridges circuits to #consciousness. Thanks to my co-authors, especially Andy Dykstra, for leading this effort!
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The BRAIN Initiative has been an engine of innovation but is now fighting for its survival. Here we discuss why BRAIN is special and why we must all fight for it now nature.com/articles/s41593-0… @TheHongLab @DrZoePhD @bjmarlin @doristsao @moriel_z @HongkuiZeng XiaokeChen ZivWilliams
The BRAIN Initiative: a pioneering program on the precipice

The BRAIN Initiative: a pioneering program on the precipice

Nature Neuroscience - Launched in 2013, the BRAIN Initiative (BRAIN) in the United States aimed to unlock the mysteries of the brain and develop new treatments for neurological and neuropsychiatric...

nature.com
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anyone interested in working on analysis of *directed* graphs of whole brain networks (at the region-to-region level, i.e. high SNR fMRI data in mice)? e.g. making predictions using network control theory & testing them? we're hiring. ping me at [email protected]
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If you are at #SPR2024 @TheRealSPR and enjoy thinking about circuit mechanisms of EEG, consider checking out Symposium VIII.4 on Sat. - I’ll be presenting @HNNsolver microcircuit models of the stop-signal frontocentral ERP (alongside prelim beta event modeling, as a treat)! 🛑🧠
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david 为 zhou retweeted
Andreas Horn (@andreashorn_) profile picture
Andreas Horn@andreashorn_18 Oct 2024
Fantastic, authoritative & comprehensive ‘roadmap’ article out in @NatRevNeurosci by Segobin et al. about in vivo segmentation of the thalamus. nature.com/articles/s41583-0…
Image from Andreas Horn (@andreashorn_)
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Alpha coherence is a network signature of cognitive recovery from disorders of consciousness medrxiv.org/content/10.1101/… #neuroscience
Alpha coherence is a network signature of cognitive recovery from disorders of consciousness

Alpha coherence is a network signature of cognitive recovery from disorders of consciousness

Alpha (8-12 Hz) frequency band oscillations are among the most informative features in electroencephalographic (EEG) assessment of patients with disorders of consciousness (DoC). Because interareal...

medrxiv.org
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david 为 zhou retweeted
Nick Tolley (@NickTolley4) profile picture
Nick Tolley@NickTolley430 Apr 2023
Here's a 🧵on our latest preprint! Detailed neural models enable novel neuroscience discoveries and many models are now openly distributed. Below is an example of our modeling software @HNNsolver for interpreting cell/circuit elements underlying M/EEG🧠 biorxiv.org/content/10.1101/…
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Here, we studied how MEG oscillatory slowing could be characterized by transient spectral event features, in a population of mild cognitive impairment (MCI) patients who later converted to AD (CONV), compared to those who do not converted to AD (NOCONV).
Image from Danylyna Shpakivska Bilan (@shpakivskad)
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While I’m not a consciousness theorist, I welcome all discussions about the “posterior hot zone” and IIT. It’s something we wondered about…
david 为 zhou (@dvwz) profile picturedavid 为 zhou@dvwz11 Oct 2024
Replying to @dvwz @dngman
We believe this is the same posterior component that is disrupted when patients lose consciousness during general anesthesia induction with propofol (Purdon 2013 PNAS).
Image from david 为 zhou (@dvwz)
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I just posted a major piece of my graduate research, where we used global coherence (previously used with EEG recordings of general anesthesia) to characterize coherent networks of alpha oscillations in disorders of consciousness medrxiv.org/content/10.1101/…
Alpha coherence is a network signature of cognitive recovery from disorders of consciousness

Alpha coherence is a network signature of cognitive recovery from disorders of consciousness

Alpha (8-12 Hz) frequency band oscillations are among the most informative features in electroencephalographic (EEG) assessment of patients with disorders of consciousness (DoC). Because interareal...

medrxiv.org
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(Part of the backstory: this whole study was initiated (as so many are) by an almost offhand comment that my advisor Emery Brown made about global coherence never having been explored in this patient population. Glad we went down this road!)
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And special thanks too to my advisors and colleagues who taught me more about this technique and in so much detail @PurdonLab @emilyps14
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