
MD PhD neuroscientist | Visiting Postdoc @Columbia with @bjmarlin | PhD with @OferYizhar @WeizmannScience | Studying oxytocin & early-life social behavior
Israel
Joined September 2015
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New in @ScienceMagazine! 🎉 Thrilled to share my PhD project, we introduce a new optogenetic approach to study the developing brain - revealing how oxytocin shapes infant behavior.
Thanks to my collaborators, @OferYizhar & my family❤️
science.org/doi/10.1126/scie…
Here’s the story🧵
Daniel Zelmanoff retweeted
I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @ScienceMagazine, where we recorded neurons in bats flying outdoors on an island.
doi.org/10.1126/science.adw6…
With Saikat Ray, @ShirRMaimon, @LasLiora, Nachum Ulanovsky and many others
Daniel Zelmanoff retweeted
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has on the well-being of myself, my team, and pretty much every scientist I know (maybe you’ve noticed from my stupid jokes… :) I was exhausted of dealing with the huge delays, reviewers that can be abusive, and how arbitrary it all is. Unfortunately, the most important factors are often WHO your reviewers are and who YOU are... It’s clear we need alternatives or at least ways to improve the situation. So, together with a really special and talented team we worked to develop this idea into “qed” a platform where you can get CONSTRUCTIVE feedback on your own work or CRITICALLY assess other people’s papers. It can be a real difference maker if many of you join us (thousands have tried it already, but today we release a NEW and much stronger version ;) Let’s harness qed to put the power back in the scientists’ hands, to do, to read & to publish science on our own terms. I’m dying for you to TRY IT, and it’s very simple - just drop a paper (the link to the website is in the replies👇) - it’s completely secure, private, and free, and you get results fast. Please show your support, SHARE, tell your friends, and let’s be the revolution 🫵!
Paper: science.org/doi/10.1126/scie…
Yizhar Lab: weizmann.ac.il/brain-science…
Together, these findings reveal oxytocin’s crucial role in shaping early-life bonding, and our new tool opens opportunities to explore the developing brain 🧠
This was a long journey and a true team effort!❤️ Huge thanks also to Shari Ross for her beautiful drawings!
We found that oxytocin neurons became more active during separation, and this activity was tightly linked to pups’ calls.
Blocking or silencing oxytocin changed calling - not only during separation but also at reunion with the mother.
Studying the infant brain is tough. To overcome this, we combined behavior, fiber photometry, and pharmacology with a new wireless, noninvasive optogenetic method. This let us monitor & manipulate oxytocin neurons in freely behaving pups 🐭💡
Oxytocin is famous for shaping adult bonding. But in early life, its role was unclear.
We noticed oxytocin receptors strongly expressed in infancy, in both humans and mice - yet their function was unknown. We asked: how oxytocin influences pups’ cries during separation & reunion?
Daniel Zelmanoff retweeted
I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3
Daniel Zelmanoff retweeted
How does the auditory cortex first start responding to sounds and change over time? Come to my #SfN24 poster tomorrow (Wed) morning G1 to check out my postdoc work with @Froemkelab on longitudinal 2P imaging of mouse auditory cortex from hearing onset (P12) into adulthood!
Daniel Zelmanoff retweeted
A method that renders skin temporarily see-through could offer researchers a non-invasive way to look inside the bodies of live mice go.nature.com/3XxLC5Z
Daniel Zelmanoff retweeted
Our new @natureneuro paper is out!
We employed circuit manipulations in transgenic WILD MICE, revealing a sexually dimorphic role of oxytocin neurons in social conflict.
An admired team effort led by @ItsikSofer with our programmer Silvia Chuartzman
nature.com/articles/s41593-0…
I'm so proud to share my Ph.D. work from @OferYizhar's lab, now on bioRxiv. We developed a new approach for transcranial optogenetic silencing in untethered and freely-behaving pups, exploring the role of oxytocin in early-life social behavior >>
biorxiv.org/content/10.1101/…
Couldn't have done it without this incredible team: Menachem, @JulienDine, @JWietek, Anna, Shaked, Savanna and the one and only @OferYizhar ❤️💜💚
Daniel Zelmanoff retweeted
מחשבות:
1. קודם כל תצפו בזה
2. קייסי נייסטאט הוא גאון. הביקורת הזו שונה לחלוטין מכל מה שראיתי
3. יש פה הצצה לעתיד, שנראה קצת כמו גרסה ריאליסטית של ready player one
4. כשכולם ילבשו אחד כזה, גם אתם תלבשו אחד כזה
5. כשיוסיפו פנימה שליטה קולית תהיה קפיצה ענקית
6. קשה לחכות להמשך
Daniel Zelmanoff retweeted
Introducing #OptoGRC2024 chair @OferYizhar!
Ofer is an associate professor @WeizmannScience & an amateur ultra-marathoner who used to dream of becoming a musician! 🏃♂️🎶
Ofer is excited about the meeting’s strong global presence & bringing the Opto community together in Tuscany!
Daniel Zelmanoff retweeted
🚨 Exciting Discovery Alert! 🤯 Our new research uncovers Williams Syndrome as a mitochondrial disorder! 🧬 Gtf2i, a key gene, plays a crucial role in brain development. Deletion triggers abnormal mitochondria, disrupted mRNA, and altered protein expression.
A neurobiological study reveals Gtf2i's pivotal roles in brain development and mediating neuronal mitochondrial function, validated by human brain samples derived from individuals with Williams syndrome.
@barakboaz @GiladLevy7
nature.com/articles/s42003-0…
Daniel Zelmanoff retweeted
I was ashamed to hear the recent testimony of 3 top university presidents. In my personal opinion, it was one of the most despicable moments in the history of U.S. academia. The 3 Presidents were offered numerous opportunities to condemn racist, antisemitic, hate rhetoric and refused doing so hiding behind calls for “context.” The memories of my father’s parents, Abraham and Rachel Bourla, his brother David and his little sister Graciela, who all died in Auschwitz, came to mind. I was wondering if their deaths would have provided enough “context” to these presidents to condemn the Nazis' antisemitic propaganda.
And because dehumanization of the victims makes it easier to “set your own context” and justify anything, here is a picture of Graciela Bourla, who was exterminated in the concentration camp at the age of 17. Unfortunately, no pictures of my grandparents and uncle survived. I still wonder what they looked like.
Wow.
Harvard, UPenn, MIT presidents would not give a straight answer to @RepStefanik's question on whether calling for the genocide of Jews constitutes bullying and harassment against Jewish students.
If you’re attending the #SfN2023 and interested in oxytocin and early-life social behavior, come check out my poster where we designed an optogenetic approach for transcranial modulation of oxytocin signaling and pups’ social behavior.
@OferYizhar



























