@ebennettlab

The Bennett Lab specializes in all things related to ubiquitin and protein homeostasis

 San Diego, CA
ebennettlab.com/
Joined October 2019
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.@UCSDMedSchool researchers unlock a way to keep lab-grown stem cells healthy, which is positive news for people who need bone marrow transplants when donor stem cells are not available. The approach may also help further aging research. ow.ly/nSpg50FR4Vi
Illustration showing the HSF1-mediated heat shock pathway that promotes proteostasis in hematopoietic stem cells in culture and during aging. Photo credit: Cell Press

ALT Illustration showing the HSF1-mediated heat shock pathway that promotes proteostasis in hematopoietic stem cells in culture and during aging. Photo credit: Cell Press

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Almost one full year after the preprint (🚽), we can finally present the final version of our HUWE1 manuscript! Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition cell.com/molecular-cell/full…

Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

Hunkeler et al. present the cryo-EM structure of HUWE1, a large HECT E3 ligase that forms a modular ring-shaped assembly with flexibly attached accessory domains. The influence of mutations associa...

cell.com
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Read our latest work here. #RQC #ribosomes #ubiquityltion #proteostasis. A @ebennettlab @Daugherty_Lab collab. We identify a conditional requirement for ZNF598 during vaccinia infection. ISR suppression is the conditional requirement. thanks to all the @amitfulzele2006
bioRxiv@biorxivpreprint13 Nov 2020
Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection biorxiv.org/cgi/content/shor… #bioRxiv
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Excited for #cshlubiq to (virtually) start soon! Step by posters-#106 and #136 for some HUWE1/HECT discussions!
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Amazing primer on how the sarscov2 vaccine got its WARP speed
Eric Topol
@EricTopol13 Dec 2020
Why 2 proline (P) substitutions will go down in history. Introducing 2P's at the beginning of the central helix (CH) stabilized the spike protein's confirmation upon entering cells. From the Jan 10 #SARSCoV2 sequence, this 2P Δ was incorporated into the mRNA vaccine designs /1
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Quality Control Mechanisms Inside Cells Help Clear Collisions: Research published in eLife led by Danielle Garshott, Eric Bennett and their colleagues reveals ribosome serves as a unique signaling hub for quality control signals. go.ucsd.edu/2ToYdHN
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