ECLip

Patient-derived iPSCs reveal a lasting cellular memory of progeria. In Wiedemann–Rautenstrauch syndrome, differentiation exposed early senescence, genome instability and telomere shortening. @SpringerNature pubmed.ncbi.nlm.nih.gov/4292… #LPoM #lipodystrophy

Caveolae are more than membrane dimples. This review explains how caveolin and cavin mutations disrupt lipid handling, signalling and membrane mechanics—linking them to lipodystrophy. @physiolrev pubmed.ncbi.nlm.nih.gov/4293… #LPoM #lipodystrophy

Can DXA sharpen the differential diagnosis of FPLD? Regional fat-distribution indices separated FPLD, lipoedema and obesity in women—useful objective phenotyping, not stand-alone diagnosis. @SpringerNature pubmed.ncbi.nlm.nih.gov/4295… #LPoM #lipodystrophy

A monoallelic TRIM28 variant may define a new interferonopathy. This family showed chilblains, ulcers, calcinosis and lipodystrophy, with high IFN signalling and partial response to baricitinib. @BMC_series pubmed.ncbi.nlm.nih.gov/4290… #LPoM #lipodystrophy

An unusual neonatal clue to CGL1: transient immature brown-fat masses. Severe hypertriglyceridaemia led to AGPAT2 diagnosis before the full lipodystrophy phenotype emerged. @KargerPublisher pubmed.ncbi.nlm.nih.gov/4291… #LPoM #lipodystrophy

Could one injection replace daily leptin? In a CGL mouse model, AAV-leptin—but not AAV-adiponectin—improved steatosis and hyperinsulinaemia, supporting durable gene-based hormone delivery. @NaturePortfolio pubmed.ncbi.nlm.nih.gov/4291… #LPoM #lipodystrophy

Which mouse model fits the question? This review maps models—from LmnaG609G to natural ageing—to the mechanisms they can reveal. @ISOAD2018 pubmed.ncbi.nlm.nih.gov/4285… #LPoM #lipodystrophy

Patient advocacy is part of the science. AIProSaB connects progeria families, research and therapeutic progress around LMNA/progerin biology. @FEBS_Letters pubmed.ncbi.nlm.nih.gov/4286… #LPoM #lipodystrophy

Metreleptin may do more than improve glycaemia in Werner syndrome: this case also reports improved hepatic steatosis in partial lipodystrophy. @jstage_ej pubmed.ncbi.nlm.nih.gov/4287… #LPoM #lipodystrophy

MDPL can mimic Werner syndrome—but the skin can help distinguish them. This case highlights POLD1-related lipodystrophy, telangiectasias and soft-tissue calcification. @WileyGlobal pubmed.ncbi.nlm.nih.gov/4288… #LPoM #lipodystrophy

Can progerin-driven ageing be switched on at will? New inducible hiPSC lines provide matched LMNA, progerin and GFP controls for precise cellular-ageing models. @ElsevierConnect pubmed.ncbi.nlm.nih.gov/4286… #LPoM #lipodystrophy

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Werner syndrome puts genome maintenance center stage: this review links WRN dysfunction, replication stress, telomere crises and cellular senescence in progeroid aging. pubmed.ncbi.nlm.nih.gov/4097… #LPoM #lipodystrophy @ResearchKarger

Progerin distorted dermal fibroblast nuclei in vivo, yet limited expression did not impair wound healing or hair regrowth — refining how we model progeria pathology. pubmed.ncbi.nlm.nih.gov/4282… #LPoM #lipodystrophy @ElsevierConnect

Why does skin fibrosis erase fat? Wnt-driven oxidative stress and lipid peroxidation caused dermal lipodystrophy in vivo; scavengers protected both fat and collagen architecture. pubmed.ncbi.nlm.nih.gov/4283… #LPoM #lipodystrophy @FEBSnews

A newborn with mandibuloacral dysplasia type B carried novel compound-heterozygous ZMPSTE24 variants—expanding the genetic and clinical map of this rare lipodystrophy. pubmed.ncbi.nlm.nih.gov/4283… #LPoM #lipodystrophy @FrontiersIn

Liraglutide in congenital generalized lipodystrophy: a small series found lower HbA1c and insulin needs after 12 weeks, but GI intolerance limited treatment. pubmed.ncbi.nlm.nih.gov/4284… #LPoM #lipodystrophy @FrontiersIn

Tirzepatide in partial lipodystrophy: this retrospective series found improvements in weight, HbA1c, triglycerides and insulin needs. A promising signal needing prospective confirmation. pubmed.ncbi.nlm.nih.gov/4186… #LPoM #lipodystrophy @JCEMed