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Edilytics (@edilytics) profile picture

Edilytics

@edilytics

Precision analytics for genome editing. Creators of CRISPResso2.

edilytics.com/
Joined February 2019
  • Tweets254
  • Following128
  • Followers93
3Media
Photo by Edilytics (@edilytics)Photo by Edilytics (@edilytics)Photo by Edilytics (@edilytics)
We're leading the next generation of gene editing and are excited to make our Twitter debut. Follow us to stay in the loop on all things $PRME.
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Thrilled to share our work on Gene Editing for #GM1 #gangliosidosis. Base Editing seems to be an alternative approach to treat patients @CureGM1 by ⁦@Delphine_Lclrc⁩ : She is looking for a PostDoc position !!!!! @Inserm, ⁦@CSignaling⁩ pubmed.ncbi.nlm.nih.gov/3662…
Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient - PubMed

Gene Editing Corrects In Vitro a G > A GLB1 Transition from a GM1 Gangliosidosis Patient - PubMed

Ganglioside-monosialic acid (GM1) gangliosidosis, a rare autosomal recessive disorder, is frequently caused by deleterious single nucleotide variants (SNVs) in GLB1 gene. These variants result in...

pubmed.ncbi.nlm.nih.gov
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New OA Article: "Widely conserved AHL transcription factors are essential for NCR gene expression and nodule development in Medicago" rdcu.be/c26oJ Expression of Medicago NCR genes in soybean is induced by conserved transcription factors in the symbiotic nodule cells.
Image from Nature Plants (@NaturePlants)
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RagTag, from @malonge11, @mike_schatz, @SebastianSoyk & co, is a toolkit for automated scaffolding of genome assemblies, and patching them. The authors apply it to two tomato genomes, to facilitate editing for crop improvement genomebiology.biomedcentral.…
Contig boundaries in the final assemblies of two tomato genomes

ALT Contig boundaries in the final assemblies of two tomato genomes

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Excited to see our study "Predicting prime editing efficiency and product purity by deep learning" published in @NatureBiotech today! @schwanklab @krauthammerlab nature.com/articles/s41587-0… 1/14
Image from Nicolas Mathis (@nicopmat)
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As presented at CSHL CRISPR Frontiers, I'm excited to share our new manuscript on the discovery, biochemistry, & structural insights of novel phage-derived CRISPR-Cas systems and their development into gene-editing tools! Now published @CellCellPress sciencedirect.com/science/ar…
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In our new paper published in @NatureComms we characterize the on-target activity and off-target propensity of SuperFi-Cas9 in mammalian cells and also see strongly reduced activity but with high fidelity features. @BiochemBrc doi.org/10.1038/s41467-022-3…
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Replying to @edilytics @bonohu
Thank you for checking our review article. #crispresso2 is one of the most commonly used tools in #CRISPR editing. We are happy to share information about your tools!!!
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Today we report in @NatureBiotech the conversion of adenine base editors (ABE) into next-generation cytosine base editors (TadCBEs) with high on-target activity and reduced off-target activity using phage-assisted continuous evolution (PACE). 1/14 drive.google.com/file/d/1XY3…
Image from David R. Liu (@davidrliu)
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Replying to @edilytics @NaldiniLab
Thank you for developingCRISPResso2! It was really pivotal for our analyses!
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Edilytics retweeted
Jacob Corn (@jcornlab) profile picture
Jacob Corn@jcornlab5 Aug 2022
Today in @natcomms we report #RecursiveEditing: a way to drive high levels of #CRISPR #HDR without manipulating the cellular factors or state. Project co-led by Masters' student Lukas Möller and postdoc Eric Aird. nature.com/articles/s41467-0… 🧵
Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Nature Communications - CRISPR-Cas induced HDR methods tend to have a low efficiency. Here the authors report an HDR improvement strategy, Recursive Editing, that selectively retargets undesired...

nature.com
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Replying to @edilytics @BuchholzLab_TUD
Thanks for developing such a great tool! We love crispresso2! ❤️🧬☕️
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Replying to @edilytics
Thanks for this great tool, which helps our research so much!
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Replying to @edilytics @bishop_alena @ValentinoGantz @KomorLab
We love crispresso2!
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🚨 ONE WEEK LEFT 🚨 to submit your abstract and be considered for an oral presentation at CRISPR2022 🧬 Register now at crispr2022.bio to join us for 4 days of #CRISPR fun, June 12-16 in Boston!
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