@emmapeterman_

ChemE PhD student @GallowayLabMIT

 Cambridge, MA
emmapeterman.notion.site/research
Joined August 2020
  • Tweets33
  • Following201
  • Followers134
3Media
Emma Peterman retweeted
Katie Galloway
@GallowayLabMITJul 8
Congrats, @emmapeterman_ on a terrific defense! An whirlwind journey to characterize gene elements at high resolution and to build improved circuit designs and frameworks that accelerate the Design-Build-Test-Learn loop! Cheers to a job well done! Excelsior! @MITChemE
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Enjoyed the tweetorial? Want to hear more? Come hear @emmapeterman_ live at AIChE this coming Thursday. Details 👇 Thursday, November 6th, 2025 Session #654: Cellular, Protein, & RNA Systems Engineering 8:00 AM, Hynes Convention Center, 310
Katie Galloway
@GallowayLabMIT26 Jun 2025
So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein levels. 🧵
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So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein levels. 🧵
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Today at @CellSystemsCP we report in back-to-back papers (!) led by @nbwang22 on how cell state potentiates the influence of individual transcription factors to drive cell-fate programming & how we used these insights to scale up production of motor neurons from primary fibroblasts, allowing us to deliver these directly converted neurons into the brains of mice. Updated tweetorial coming soon (links below!)
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Your promoter is doing both more and less than you might expect. @MITChemE
bioRxiv Synthetic Biology@bioRxiv_synbio27 Nov 2024
High-resolution profiling reveals coupled transcriptional and translational regulation of transgenes biorxiv.org/cgi/content/shor… #biorxiv_synbio
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Stronger promoters not only transcribe more RNA but also show higher effective translation rates.
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#FeaturedProtocol this week is for STRAIGHT-IN: a platform for rapidly generating panels of #geneticallymodified #humanpluripotentstemcell lines bit.ly/3yJXlVP @A_BlanchAsensio
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Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n) Link: doi.org/10.1101/2024.06.19.5…
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Or stop by poster #28 to hear from Emma Peterman @emmapeterman_ on her work on "Simultaneous measurement of protein and mRNA levels in single cells for genetic element characterization" in mammalian cells #SEED2024 #synbio @MITChemE
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on unimodal setpoints and how to get them from synthetic promoters... tweetorial coming soon... or see you next Thursday #SEED2024 in Atlanta... Stay tuned for more control systems coming soon...
bioRxiv Synthetic Biology@bioRxiv_synbio21 Jun 2024
Programmable promoter editing for precise control of transgene expression ift.tt/RchaKp6 #biorxiv_synbio
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Excited to say our lab's about to do some "understanding and engineering" with the support of the NSF CAREER Award! Really grateful for fantastic work by my students and support from my department @MITChemE Delighted for the research and outreach this will support. Excelsior!
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1st preprint is finally out! When I started, as a 🤖 synbio person, there were so many Q's I had on how to build reprogramming vectors 🔧🧬. There's a lot more to do but we show how you encode reprogramming cocktail really matters in TF-specific ways! See tweetorial for more
Katie Galloway
@GallowayLabMIT27 Nov 2023
How do individual transcription factors (TF) influence reprogramming? Isn’t it just the cells with the highest levels of TF expression that reprogram? So just blast them & it should work, right? 🤨Buckle up for our lab’s preprint & tour de force led by Nat Wang @nbwang22 ! (1/n)
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How do individual transcription factors (TF) influence reprogramming? Isn’t it just the cells with the highest levels of TF expression that reprogram? So just blast them & it should work, right? 🤨Buckle up for our lab’s preprint & tour de force led by Nat Wang @nbwang22 ! (1/n)
bioRxiv Cell Biology@biorxiv_cellbio27 Nov 2023
Proliferation history and transcription factor levels drive direct conversion biorxiv.org/cgi/content/shor… #biorxiv_cellbio
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If you’re at #ISSCR2023 , come see my poster #285 on Wed, 6pm! Excited to share my work on how we’ve systematically optimized direct iMN reprogramming to explore and improve controllability of reprogramming in both 🐭 mouse and 👤 human!
Katie Galloway
@GallowayLabMIT13 Jun 2023
Replying to @GallowayLabMIT
Wed Jun 14th 6pm: Come to poster #285 and hear Nat Wang tell you about his work on the systems biology-guided design and molecular optimization of circuits for cell fate reprogramming. Nat also won an ISSCR Merit Award for his abstract! (1/n)
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How does transcription of proximal genes influence the expression of their neighbors? How do we engineer compact circuit designs for specific profiles of expression that enable robust cellular engineering? Today @CellReports we provide some answers (1 /n) tinyurl.com/24vtfbyw
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Emma Peterman retweeted
Elisa Granato@Prokaryota30 Aug 2022
"are you ok?" - no I have to pipette 1008 uL
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Excited to share our new @biorxivpreprint! Integrating DNA biophysics with classic #synbio to map how to improve transgenic systems by tailoring expression levels, variance, and transcriptional dynamics. TL;DR: Don’t build your systems to fail. Build beautiful dynamics! 🧵(1/n)
bioRxiv Synthetic Biology@bioRxiv_synbio20 Apr 2022
Supercoiling-mediated feedback rapidly couples and tunes transcription ift.tt/L5NhVKB #biorxiv_synbio
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Emma Peterman retweeted
Science Haikus@HaiOnSci2 Feb 2022
Insert has an error Six more weeks of PCR Cloning groundhog day
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Primordium is now offering everyone the chance to sample our full-plasmid sequencing service for FREE - never use Sanger sequencing again! Please retweet this message and we'll DM you a coupon to sequence 5 ENTIRE PLASMIDS 100% FREE, no CC or PO needed. primordiumlabs.com 5/
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Its signing day @MITChemE! Delighted to be welcoming Emma Peterman @emmapeterman_ to lab. She joins us from UD as an alumna of @cfromen lab. Excited to watch Emma launch into building synthetic models of tissue regeneration! (Also, yes, signing day is now signing month)
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