Don

Dear BioAI, MedAI, SynBio and biohacking community, We are very happy to present the very first on-chain bioinformatics laboratory, as a part of the broad GenesisL1 decentralized science architecture: gl1x.com/bio — Bioinformatics Onchain Free. No account. Open to humans, programs and AI agents. What it is GenesisL1 carries hundreds of thousands of protein and nucleic acid structures published as MolNFT records, stored in contract state or anchored on chain with CID-verified IPFS content. GL1X treats that archive as a scientific database and runs the standard methods of sequence and structure bioinformatics over it, in its own code, with no external services, and each method validated against its reference program. This is not a wrapper around someone else's server. It is a laboratory that lives on the chain. What you can do today 🔎 Search & homology — molecular search by PDB ID, UniProt accession, NFT id, title, sequence or motif; full BLAST (blastp/n/x, tblastn, tblastx) over every sequence, identical to NCBI BLAST+ on the test set; PROSITE-style motif scans across sequences and 3D structures; profile HMM search reproducing the hmmsearch pipeline. 🧬 Structure — TM-align superposition of any chain against any other (or your own file); structure search over every indexed chain in seconds via the GSA structural alphabet; pre-computed experiment-vs-prediction comparisons for every UniProt accession present as both. 🔬 Full-atom analysis in the research workbench — DSSP secondary structure and H-bonds, accessibility, half-sphere exposure, contact maps, base pairs with pseudoknots, chain interfaces with buried surface, salt bridges; SS-pattern search (β-hairpins, helix-turn-helix); 3D templates for catalytic triads and metal sites. 💊 Pockets & druggability — cavities with volume, buriedness, hydropathy, charge and a druggability score, searchable across every structure; a ligand index of every cofactor, drug, ion and sugar with its binding-site residues. 🧪 pH environments — structure-based pKa for every ionizable group; charge, pI and stability of a protein in the stomach, intestine, blood, cytosol, endosome or lysosome, with membrane proteins getting a pH on each side. ⚗️ Proteomics — digestion by 24 enzymes, proteotypic peptides across the archive, masses, fragments, isotope patterns, MGF spectrum identification with target-decoy FDR, crosslink checks, HDX/LiP painting, a virtual 2D gel. 🌳 Families, evolution & variants — multiple alignment at MUSCLE-level accuracy, Jensen-Shannon conservation on the structure, NJ trees, mean-field DCA coevolution vs contacts, CD-HIT clustering, disorder/coiled-coil/TM annotation, substitution scans and ΔΔG from GL1F models. 📊 Datasets & on-chain ML — turn any search into a dataset (JSON/CSV/TSV) with documented features, or straight into GL1F model inputs; train off chain, publish the model as an NFT, run it on GenesisL1 on any record. 📚 Literature — PubMed search with up to 2,000 records clustered into a topic map in your browser (Broccoli), every structure linked to its literature. ✅ Proofs — every sequence in every result can be re-derived from the chain at a pinned block and from IPFS, with the calls to replay on your own node. Every hit names the record and the SHA-256 of what it describes. Deterministic answers, reference parity, held-out evaluation. 🤖 Agent-native — every tool above is an MCP tool and an API endpoint. An agent can identify a molecule, BLAST it, find its structural neighbours, analyse its pockets, digest it, align its family, scan its variants, read its literature, build a dataset, run a model and prove the sequences, end to end. Where this is going This is the opening move. The horizon is expanding constantly: the full human reference genome and pilot genomes are coming into chain state through GL1-seq, with 1000+ public genomes to follow, alongside Swiss-Prot, RefSeq proteins, UniRef50, paired antibody repertoires and IPD-IMGT/HLA. Peptide design (PEPTL), confidential IP (CIPNFT), scientific DAOs (COLLAB) and DeSci finance (DESCIFI) are being built around the same core. Our aim is simple and ambitious: hundreds of thousands of researchers working on decentralized infrastructure, with tools and services for open science expanding at a pace the field has not seen before. This is an invitation Research on chain. Build on chain. Point your agents at the MCP server, call the API, fork the explorer, publish a model, mint your structures. Everything you compute here is provable, reproducible and belongs to no single server. → gl1x.com/bio · Docs: gl1x.com/docs/bioinformatics · API: gl1x.com/docs/api · MCP: gl1x.com/docs/mcp Welcome to the laboratory. GenesisL1