@fodorlab

We're a molecular and structural virology lab working mainly on influenza @Dunn_School, @UniofOxford

 Oxford, England
fodor.path.ox.ac.uk/
Joined November 2020
  • Tweets313
  • Following458
  • Followers1.3K
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Fodor Laboratory retweeted
nature
@NatureMar 9
Nature research paper: Mechanism of co-transcriptional cap snatching by influenza polymerase go.nature.com/4rTklIc

Mechanism of co-transcriptional cap snatching by influenza polymerase

Nature - Structural and biochemical studies of influenza virus RNA-dependent RNA polymerase (FluPol) in complex with transcribing host RNA polymerase II reveal the molecular mechanisms of RNA cap...

nature.com
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Fodor Laboratory retweeted
Achillefs Kapanidis@AchillesKapJan 30
Great to see our new Science Review on emerging multiplexed measurements that link the sequence of single molecules to their dynamics! From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science science.org/doi/10.1126/scie…

From sequence to function: Bridging single-molecule kinetics and molecular diversity

Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape...

science.org
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Very happy to have been able to contribute to this study that was published today in Science, which was truly a great collaborative effort. Avian PB1 provides a fitness advantage to IAV at febrile-range temperatures both in vitro and vivo 🦠 #flu #virology science.org/doi/10.1126/scie…

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted...

science.org
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Officially starting my DPhil in Condensed Matter Physics in @AchillesKap and @fodorlab ! A collaborative project to understand influenza dynamics. Excited to see where this project goes!
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Fodor Laboratory retweeted
Daniel Weir@DanielWeirIAV6 Jun 2025
🚨🔎 Out now in @PLOSPathogens! 🔎🚨 This project has taken us @CVRinfo @UofGMVLS on a wild and wonderful journey. I am excited to share our story of how influenza A viruses (IAVs) exploit cell death to facilitate its covert spread. N/1 journals.plos.org/plospathog…
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Europe needs a sustainably funded influenza research and response network - especially in the light of H5N1 and current developments in the US. Read our commentary in The Lancet ID: thelancet.com/journals/lanin… With @wendybarclay11, @MarionKoopmans and many other colleagues.

Europe needs a sustainably funded influenza research and response network

Influenza viruses have caused four pandemics during the last century.1 The 1918 H1N1 pandemic claimed 20–50 million lives, the 1957 H2N2 pandemic and the 1968 H3N2 pandemic claimed 1–4 million lives...

thelancet.com
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Very concerning to see a second introduction of H5N1 I to dairy cattle. It’s been reported to be from the D1.1 genotype which is widely circulating in birds in North America. It will be critical to examine the sequences for signs of host adaptation 🦠🐄 statnews.com/2025/02/05/usda…

USDA milk testing shows different strain of H5N1 bird flu in Nevada dairy herds

The USDA said four Nevada dairy herds were infected with an H5N1 bird flu strain that has circulated in wild birds, making prospects for containment in cows appear dim.

statnews.com
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Decoding viruses. Defying limits. 🦠🔍 Prof @wendybarclay11 has dedicated her career to unpicking viral mysteries. Now, she's been appointed Regius Professor—the first woman to hold the prestigious title at @imperialcollege ⤵️ #WomenInSTEM imperial.ac.uk/Stories/Wendy…

Decoding viruses and defying limits: Professor Wendy Barclay appointed Regius Professor

A life dedicated to understanding viruses with pandemic potential

imperial.ac.uk
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Fodor Laboratory retweeted
Jeremy Farrar@JeremyFarrar1 Feb 2025
Virologist Wendy Barclay: ‘Wild avian viruses are mixing up their genetics all the time. It’s like viral sex on steroids’ Always worth listening to ⁦@wendybarclay11⁩ ⁦@imperialcollege⁩ theguardian.com/science/2025…

Virologist Wendy Barclay: ‘Wild avian viruses are mixing up their genetics all the time. It’s like...

The British scientist on the risk of humans contracting bird flu, how people would cope with new lockdowns and being asked to pour the tea because she is a woman

theguardian.com
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Fodor Laboratory retweeted
Alex Borodavka@AlexBoRNA12 Jan 2025
Interested in joining our growing interdisciplinary team studying viruses, RNA, and condensates? Looking for a postdoctoral position? Please consider joining us in Cambridge, UK, or drop us a line to discuss these opportunities: jobs.cam.ac.uk/job/49901/
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Fodor Laboratory retweeted
Nicole Robb@nicole_robb111 Dec 2024
An image representing our work made the cover of Biophysical Reports! If you're interested check out the paper at cell.com/biophysreports/full…. Thanks again to everyone involved @CVRHutchinson @SwethaVijayakr1 @daniellegroves_ @Hafezelsayyed and not-on-X Andrew McMahon :)
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Just published—avian origin and pandemic PB1 genes from influenza A viruses influence replication and pathogenesis in an avian influenza viirus. Happy for this story to be out and thank you to my co-authors 🦠 #influenza #virology #womeninSTEM science.org/doi/10.1126/scia…

Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and...

Past influenza pandemics contained polymerase genes from avian influenza viruses, affecting viral replication and pathogenicity.

science.org
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The abstract submission for the Annual Meeting of the Society for Virology (GfV, @GesVirologie) is open till 1 December 2024! GfV is officially affiliated with our Journal of General Virology (#JGenVirol).Don't miss the opportunity to share your research! microb.io/3NMmClQ
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Fodor Laboratory retweeted
Nicole Robb@nicole_robb117 Oct 2024
Very proud of our latest preprint - using single-molecule assays to explore SARS-CoV-2 replication and inhibition. Thanks to all awesome co-authors @daniellegroves_ @AndrewPMcMahon @haitian_fan @JeremyKeown1 @fodorlab Read it here: doi.org/10.1101/2024.10.15.6…
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There is still time to apply! Associate professor, immunity/inflammation/infection (defined broadly) especially welcome Come and join a great community of supportive colleagues! Deadline 25 October, please spread the word path.ox.ac.uk/vacancy/associ…
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Very pleased to have been able to present my work at my first Options XII for the Control of Influenza conference in Brisbane, Australia! It’s been an amazing time of meeting old and new colleagues and discussing incredible science 🦠 spot the koala 😉🐨 #influenza @options2024
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Fodor Laboratory retweeted
John Briggs@BriggsGroup3 Jun 2024
A physical model for M1-mediated influenza A virus assembly. A combination of #cryoEM and theoretical modelling from @jpeukes and @bio_physics. Preprint here: biorxiv.org/content/10.1101/…

A physical model for M1-mediated influenza A virus assembly

Influenza A virus particles assemble at the plasma membrane of infected cells. During assembly all components of the virus come together in a coordinated manner to deform the membrane into a protru...

biorxiv.org
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Fodor Laboratory retweeted
Daniel Goldhill@influenzal16 May 2024
Love this paper. Explains so many mutations which were mysterious until now.
Fodor Laboratory@fodorlab15 May 2024
Structures of H5N1 influenza A virus polymerase with human ANP32B reveal mechanisms of replication and host adaptation. Great collaboration with @jonathan_grimes and @wendybarclay11 labs led by @CarriqueLoic @OxfordStrubi and @EccoStaller @Dunn_School nature.com/articles/s41467-0…

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and...

Nature Communications - The authors demonstrate how avian H5N1 influenza A virus polymerase interacts with human ANP32B to facilitate the replication of the viral genetic information in mammalian...

nature.com
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Fodor Laboratory retweeted
Jan Kosinski@jankosinski9 May 2024
This is the end of the world as we know it, if this is reproducible! The new era of functional modeling has begun. I took a transcription factor with an unknown structure and folded it with its recognition sequence embedded in longer DNA. AlphaFold3 accurately positioned the transcription factor.
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Fodor Laboratory retweeted
Harry Williams@harrywilliamsmx7 May 2024
🎇NEW PAPER🎇Happy to see our paper exploring phenuivirus cap-snatching published in @NAR_Open (academic.oup.com/nar/article…), with contributions from the @MariaR0senthal lab @BNITM_de, Grünewald lab @CssbHamburg @LeibnizLIV, and Cusack lab @EMBLGrenoble.
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