@fran_longo17

PI @goteborgsuni | Formerly Postdoc @KlannLab at @NYU_CNS and Ph.D. at UniFe | Dad X2 in Neuroscience

 Göteborg, Sweden
Joined August 2017
  • Tweets118
  • Following157
  • Followers90
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Excited to share that our paper on cell-type specific changes in the striatal medium spiny neurons underlying the expression of RRBs in FXS mice is finally online @CellReports. Thanks to team members from @KlannLab, @CarterAG, @NicTritsch, and @BagniLab for their contribution!1/6
Klann Lab@KlannLab1 Aug 2023
Thrilled to share @fran_longo17's latest work describing cell type-specific disruption of striatal circuitry in FXS. Many thanks to our collaborators in the labs of @CarterAG, @BagniLab, & @NicTritsch - sometimes it takes a village! sciencedirect.com/science/ar…
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🚨 PhD Position Available! Join our lab at the University of Gothenburg, Sahlgrenska Academy, focusing on the molecular mechanisms of disrupted eating behavior in Autism Spectrum Disorder. 📍 Location: Gothenburg, Sweden 🔗 Apply: web103.reachmee.com/ext/I005… 🗓️ Deadline: 2025-02-27
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Welcome to #SAJRS Day 2! Excited for another day of great talks, posters, and discussions. Let’s make it a great one! #SAJRS2025 @fran_longo17
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How does dopamine impact memory formation? 🧠 In my new Insight for @eLife, I discuss recent research revealing a distinct signaling pathway through which dopamine triggers protein synthesis, enabling the formation of long-term memories. Read more: 👇elifesciences.org/articles/1…"

Dopamine: Making memories

The neurotransmitter dopamine helps form long-term memories by increasing the production of proteins through a unique signaling pathway.

elifesciences.org
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Looking forward to presenting my research on FXS and basal ganglia at #FENS2024. Don't miss our symposium "Dissecting mechanisms of disease in ASD models for developing and testing personalised treatments". Tomorrow, Hall B at 9:45! #neuroscience #ASD fens2024.abstractserver.com/…
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Our #PhDCourse “Experimental animal models: new tools and research possibilities” will be offered again this year and applications are currently open! Only a few spots are still available. Application deadline: April 21st Read more and apply here: bit.ly/CourseSN00047
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Thank you, @Spectrum for featuring our latest work!👇
Spectrum (Autism Research News)
@Spectrum7 Aug 2023
The Broad Institute took a look back at the first year of NeuroDev. That and more highlights from social media in this week's Community Newsletter. bit.ly/3Kvj2LS
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TRAP-seq revealed altered binding of >120 mRNAs to ribosomes in dSPNs of FXS mice: elevation in mRNAs associated with ribosome and mitochondria, and reduction of those associated with cell adhesion, the synapse, and voltage-gated calcium channels 5/6
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Finally, we showed that RGS4 translation is significantly reduced in dSPNs and stimulating M4R that is upstream of RGS4, reverses repetitive behaviors in FXS mice 6/6
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Having trouble writing your first scrientific paper? Have a look at the Academic Phrasebank, provided by the University of Manchester, which is a resource to help researchers organise their writing! phrasebank.manchester.ac.uk/
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What's Future Faculty (FF) and what can it do for you? FF promotes the interests of junior researchers at @SahlgrenskaAcad, GU. If you are a junior scientist at SA, don't hesitate to contact us! medarbetarportalen.gu.se/sah…
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Francesco Longo retweeted
Cristina Maglio@cri_maglio25 May 2023
We're hiring! We're looking for someone with a strong background in metabolism for a 2-year fully financed post doc position at the Dept. of Rheumatology at the University of Gothenburg. The project is about #metabolism and #scleroderma. web103.reachmee.com/ext/I005…
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🧠#Brain research & innovation must be recognised, more than ever, as a #health and #research priority in the EU. 📃EBC, in collaboration with member & like-minded organisations, has launched a #PledgeForScience. Read more & sign the pledge 👉 bit.ly/3Ic6WG7
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Thank you @Spectrum for highlighting our new study in this week's issue of Community Newsletter!
Spectrum (Autism Research News)
@Spectrum19 Dec 2022
Microglia's previously unknown role and more social media discussion in this week's Community Newsletter. bit.ly/3HNv8iI

Community Newsletter: Chromatin regulators; dysregulated protein synthesis; microglia and myelin

This week, scientists on Twitter discussed new functions for autism-linked genes, underpinnings for restricted and repetitive behaviors, and roles for microglia.

thetransmitter.org
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Excited to share our last work from @KlannLab where we unveiled cell-type specific changes in the striatal medium spiny neurons underlying the expression of RRBs in FXS mice! A great collaboration with @CarterAG, @NicTritsch, and @BagniClaudia labs! 1/5
Klann Lab@KlannLab9 Dec 2022
Happy to share @fran_longo17's work describing how cell type-specific changes in striatal MSNs drive repetitive behaviors in FXS mice. Many thanks to @CarterAG, @NicTritsch, & @BagniClaudia labs for sharing their expertise! biorxiv.org/content/10.1101/…

Cell type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behaviour...

Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum disorder (ASD), including increased risk for restricted and repetitive behaviours (RRBs). Consistent with...

biorxiv.org
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TRAP-seq revealed altered binding of >120 mRNAs to ribosomes in dSNPs of Fmr1 KO mice: elevation in mRNAs associated with ribosome and mitochondria, and reduction of those associated with cell adhesion, the synapse, and voltage-gated calcium channels 4/5
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We showed that RGS4 translation is significantly reduced in dSPNs and treatment with a positive allosteric modulator of the M4R that is upstream of RGS4, can reverse RRBs in FXS mice. Read here: biorxiv.org/content/10.1101/… 5/5
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