Fabian Spoendlin (@fspoen) profile picture

Fabian Spoendlin

@fspoen

PhD student @OPIGlets @UniofOxford | ML for antibody drug discovery

fspoendlin.github.io
Joined January 2022
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Replying to @fspoen
@fspoen's recent antibody informatics work on improving computational epitope profiling by using more advanced structural modelling and clustering approaches has just been published in Frontiers in Molecular Biosciences: frontiersin.org/articles/10.…
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Our most recent immunoinformatics preprint details improvements to our computational epitope binning software (SPACE2): we use the latest antibody 3D modeling technology & benchmark clustering on more precise datasets. Led by @fspoen in collab w/ @Roche biorxiv.org/content/10.1101/…
Improved computational epitope profiling using structural models identifies a broader diversity of...

Improved computational epitope profiling using structural models identifies a broader diversity of...

The function of an antibody is intrinsically linked to which epitope it engages. Clonal clustering methods, based on sequence identity, are commonly used to group antibodies that will bind the same...

biorxiv.org
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