Gavin Duggan retweeted
Epstein-Barr virus infects an estimated 95 percent of adults. Infection is often silent, then lifelong. The virus causes mononucleosis and is associated with several cancers and with multiple sclerosis. Chhan and colleagues at Fred Hutch Cancer Center and the University of Washington report in Cell Reports Medicine that monoclonal antibodies raised against two EBV envelope proteins can block infection in mice that carry human immune cells.
The targets were gp350, which helps the particle bind B cells, and gp42, which participates in fusion and entry. Transgenic mice that produce human antibody genes were immunized with those proteins. Ten antibodies were isolated, two against gp350 and eight against gp42. In a humanized-mouse challenge, one gp42 antibody prevented infection. One gp350 antibody gave partial protection. Structural work on the binding sites is offered as a map for vaccine design as well as for passive antibody use.
A practical setting the authors emphasize is transplantation. Immunosuppression that prevents graft rejection also weakens control of EBV. Unchecked proliferation of infected B cells can produce post-transplant lymphoproliferative disease and lymphoma. Children who have not yet met the virus are a group in which prevention would matter most. The data do not show clearance of established latency, prevention of cancer, or prevention of multiple sclerosis in people. They show that a human-sequence antibody can stop primary infection in a mouse model that contains human lymphoid tissue. Safety studies and clinical trials remain ahead.
[Chhan, C. B., et al. (2026). Transgenic mouse-derived human monoclonal antibodies targeting EBV gp350 and gp42 provide basis for therapeutic development. Cell Reports Medicine, 7(2), 102618. DOI: 10.1016/j.xcrm.2026.102618]
Gavin Duggan retweeted
The exciting news you didn't know you were waiting for: COLOR INFINITOKENS ARE COMING!
Each color has its own unique themed design, and the 25-packs come with 5 double-sided cards of each color.
See below for the link to the announcement and more details!
Gavin Duggan retweeted
This is really great to see, and congrats, @awiltschko and the entire Osmo team! Being able to digitally manipulate scent is amazing!
(The research work underpinning this was done by Alex and a few others in Google Brain before we decided to spin it out as a separate entity. They're doing awesome stuff!)
Well, we actually did it. We digitized scent. A fresh summer plum was the first fruit and scent to be fully digitized and reprinted with no human intervention. It smells great.
Holy moly, I’m still processing the magnitude of what we’ve done. And yet, it feels like as we cross this finish line we are instantly at a new starting line. I’ll have more to share about what’s in store that we’re building on top of this.
A huge HUGE congrats to the entire team across scientific, engineering, operational, and creative disciplines. It takes a village named Osmo to do this.
I don’t know if this is embarrassing, but I carry the plum scent with me a lot of places and smell it constantly. It makes me smile.
I’m curious, if y’all want to smell it? If we made a limited release fragrance of the first teleported scent and dedicated the proceeds to science, would you want it?
Gavin Duggan retweeted
Welcome, AlphaChip!
Today, we are sharing some exciting updates on our work published in @Nature in 2021 on using reinforcement learning for ASIC chip floorplanning and layout. We’re also naming this work AlphaChip.
Since we first published this work, our use of this approach internally has grown significantly. It has now been used for multiple generations of TPU chips (TPU v5e, TPU v5p, and Trillium), with AlphaChip placing an increasing number of blocks and with larger wirelength reductions vs. human experts from generation to generation:
AlphaChip has also been used with excellent results for other chips across Alphabet, including Google’s Axion chip, an Arm-based general-purpose data center CPU.
In 2022, as a companion to the Nature paper, we open-sourced the code for the AlphaChip algorithms described in the Nature paper (see link below). Since then, external researchers could use this repository to pre-train on a variety of chip blocks and then apply the pre-trained model to new blocks, as was done and described in our original paper.
Today we’re also releasing a pre-trained AlphaChip checkpoint for the open source release that makes it easier for external users to get started using AlphaChip for their own chip designs.
Original Nature paper w/ wonderful joint first authors @Azaliamirh + @annadgoldie, and @mnyazgan, @joesmemory, @ESonghori, @ShenWangURC, @xylophi, @efjohnson, @pathomkar, @Azade_na, @PakJiwoo, Andy Tong, @kavyasrinivas23, @willhang_, @emretuncer, @quocleix, @JamesLaudon, @rh00, Roger Carpenter, and myself):
nature.com/articles/s41586-0… (PDF: rdcu.be/cmedX)
Today’s Addendum to the paper published in Nature: nature.com/articles/s41586-0… (same authors)
AlphaChip blog post: deepmind.google/discover/blo…
Open source release: github.com/google-research/c…
Pre-trained checkpoint: github.com/google-research/c…
Three things we have observed in the external community are described in the Nature Addendum: (1) not doing any pre-training (circumventing the learning aspects of our method by removing its ability to learn from prior experience) (2) not training to convergence (standard practice in ML methods), and (3) using fewer computational resources than described in our Nature paper (using fewer resources is likely to harm performance, or require running for considerably longer to achieve the same performance).
Pre-training the model for it to learn the craft of chip layout and to be able to generalize to new designs is an important part of our method. The pre-training process requires some effort to perform, since one has to find representative blocks and then run a lengthy computational process to pre-train the model to be good at placing those blocks. To avoid external users having to perform this process and make it easier for the external community to use AlphaChip, today we are releasing an AlphaChip model checkpoint pre-trained on 20 TPU blocks. This will enable users to get good zero-shot performance and faster convergence for novel blocks right out of the box. (For best results, however, we continue to recommend that developers pre-train on their own in-distribution blocks, and we provide a tutorial on how to perform pre-training with our open-source repository: see the Addendum).
Many organizations have used AlphaChip as a building block for their own chip design efforts. For example, MediaTek, one of the top chip design companies in the world, extended AlphaChip to accelerate development of their most advanced chips (e.g. the Dimensity Flagship 5G used in Samsung mobile phones), while improving power, performance and chip area.
We’re very excited about the increasing impact of AlphaChip internally and externally, and we look forward to continued work in this space to make custom higher performance, more efficient, and more capable chips dramatically easier to design and build.
Our AI for chip design method AlphaChip has transformed the way we design microchips. ⚡
From helping to design state-of-the-art TPUs for building AI models to CPUs in data centers - its widespread impact can be seen across Alphabet and beyond.
Find out more → dpmd.ai/3ZDRtYY
Gavin Duggan retweeted
I have seen rumors to the effect of "I heard @StarCityGames removed Mana Crypt/Jeweled Lotus from their buylist X weeks before the B&R announcement, is this true?" and I'm going to put this rumor to rest.
This did not happen. Here are some logs, and a thread!
(/1)
#MTG
Gavin Duggan retweeted
The comments here have been very heart-warming for me today. I thought that maybe they would be for you too, so I made a little word cloud with some of the most commonly used words.
I hope it helps to remind you why we love this game.
We'll make it, y'all.
Gavin Duggan retweeted
Decreased the format’s tendency to accomplish its design goals. This ban is about creating/curating an experience, and that’s categorically different in a way that I think makes it hard for some players to make sense of.
Gavin Duggan retweeted
It's a CARDBOARD COMBAT INVASION!
This week, we've got both Katie (@KatieCombat) and Randy (@CardboardC0mbat) here to take on Gavin and Jim! Come hang out with us and witness first-hand what mischief we get up to. 👀
Going live at 5:30PT/8:30ET!
twitch.tv/commanderrc
Gavin Duggan retweeted
Today's been a downer. Let's change that. I'm giving this Fblthp ARTY deck box away to someone.
To enter, simply follow me and retweet this post.
For a bonus entry, post a photo below that you made a donation in any amount to Save the Children.
Drawing is Friday 8/2 @ 5pm ET
Gavin Duggan retweeted
Yes, there are scores of people who want things banned/unbanned in Commander.
Also, the things they want banned/unbanned vary *immensely*, and aside from those things, they really don’t want anything else banned/unbanned.
Gavin Duggan retweeted
Magic is great because it’s so many different things to so many different people. Four player free for all is a political game full stop. It’s not like other Magic, and if that’s not what you want, it won’t be for you and that’s ok. Personally, I love it, but it’s its own thing.
Gavin Duggan retweeted
Excited to share Tx-LLM, a Large Language Model for Therapeutics. Developing therapeutics is a long road, and we're excited about the possibility of AI to contribute.
arxiv.org/abs/2406.06316
Gavin Duggan retweeted
General relativity is often called geometric, but special relativity is also a geometric theory
It explains moving at different speeds as rotations in spacetime, similar to the way we explain looking in different directions as rotations in space
Some math in this 🧵1/12
Gavin Duggan retweeted
This is the most surprising and exciting result of my career: we were running simulations of NaCl with a neural network potential that implicitly accounts for the effect of the water, ie a continuum solvent model (trained on normal MD) when Junji noticed something strange: 1/n
Gavin Duggan retweeted
Elaborate jokes that will only be understood by like 5 people on the planet are the actual best





























