生于中国，成长于赵国，谋生于美国。
Ireland
Joined July 2009
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Don’t reject a biomarker simply because it cannot be measured well in peripheral blood. Ask whether you are measuring the right analyte, in the right molecular form, in the right biological compartment.
A biomarker is not valuable simply because it is associated with disease or measurable at scale; it becomes translationally useful when the measured analyte is biologically interpretable, technically robust, and reproducible across datasets or orthogonal measurement layers.
For gene-silencing programs, “drug-targeted transcript” and “disease-relevant transcript” must be defined separately. They may overlap, but they are not necessarily identical.
Nonsense-mediated mRNA decay (NMD) guides brain development. When it fails, neurodevelopmental disorders follow. PTC position decides the outcome: haploinsufficiency vs. dominant-negative truncated protein. Key for variant interpretation & therapy. pmc.ncbi.nlm.nih.gov/article…
Detailed protocol for the design and construction of synthetic sRNAs, detailing key design principles and critical optimization factors, including scaffold selection, target mRNA binding affinity, target mRNA secondary structure, and Hfq expression levels pubmed.ncbi.nlm.nih.gov/4254…?
Immunoassay Platforms Overview: ELISA, Luminex, MSD (ECL), Digital Immunoassay, and Olink—Selecting by Throughput, LOD, and Cost cytokine.creative-proteomics…
一气呵成草就一封告别信，然后在Chatgpt和Claude之间反复修改。到了第四版时候Claude突然不改了，说你越修改，措辞越好越流利，但已经不是你自己了。你再回头看看你的第一稿，有那么一点措辞不当，少许语法错误，不够地道，但是那是真实的你，字里行间流露的情感，会让每一个被提到的人都感觉到真诚。
Mechanistic insight, biomarker development, and therapeutic innovation position RNA splicing as a tractable axis for precision cardiovascular medicine. academic.oup.com/eurheartj/a…
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A validated antibody toolbox for ALS research
elifesciences.org/reviewed-p…
